Search Results - "Chatterjee, Deepak"

‘Smart’ insulin-delivery technologies and intrinsic glucose-responsive insulin analogues by Jarosinski, Mark A., Dhayalan, Balamurugan, Rege, Nischay, Chatterjee, Deepak, Weiss, Michael A.

“…Insulin replacement therapy for diabetes mellitus seeks to minimise excursions in blood glucose concentration above or below the therapeutic range (hyper- or…”
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Structural Lessons From the Mutant Proinsulin Syndrome by Dhayalan, Balamurugan, Chatterjee, Deepak, Chen, Yen-Shan, Weiss, Michael A

“…Insight into folding mechanisms of proinsulin has been provided by analysis of dominant diabetes-associated mutations in the human insulin gene ( ). Such…”
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Structural principles of insulin formulation and analog design: A century of innovation by Jarosinski, Mark A., Dhayalan, Balamurugan, Chen, Yen-Shan, Chatterjee, Deepak, Varas, Nicolás, Weiss, Michael A.

“…The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the…”
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Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity by Racca, Joseph D, Chatterjee, Deepak, Chen, Yen-Shan, Rai, Ratan K, Yang, Yanwu, Georgiadis, Millie M, Haas, Elisha, Weiss, Michael A

“…Y-encoded transcription factor SRY initiates male differentiation in therian mammals. This factor contains a high-mobility-group (HMG) box, which mediates…”
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Ugi-type four-component reaction for a novel synthesis of 5-oxo-perhydrofuro[3,2- b]pyran carboxylate derivatives by Reddy, B.V. Subba, Majumder, Nilanjan, Gopal, A.V. Hara, Chatterjee, Deepak, Kunwar, A.C.

“…The four-component coupling (4CC) of sugar hydroxyaldehyde, Meldrum’s acid, isocyanide, and a secondary alcohol in dichloromethane has been accomplished at…”
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First example of carbohydrate-based Prins cyclization: a novel class of sugar-annulated tetrahydropyrans by Yadav, J.S., Subba Reddy, B.V., Singh, Ashutosh Pratap, Chaya, Dudhmal N., Chatterjee, Deepak, Kunwar, A.C.

“…The secondary homoallylic alcohol derived from d-glucose undergoes smooth coupling with aldehydes in the presence of molecular iodine under mild reaction…”
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NMR structure and localization of a large fragment of the SARS-CoV fusion protein: Implications in viral cell fusion by Mahajan, Mukesh, Chatterjee, Deepak, Bhuvaneswari, Kannaian, Pillay, Shubhadra, Bhattacharjya, Surajit

“…The lethal Coronaviruses (CoVs), Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV) and most recently Middle East Respiratory Syndrome…”
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New Horizons: Next-Generation Insulin Analogues: Structural Principles and Clinical Goals by Jarosinski, Mark A, Chen, Yen-Shan, Varas, Nicolás, Dhayalan, Balamurugan, Chatterjee, Deepak, Weiss, Michael A

“…Design of "first-generation" insulin analogues over the past 3 decades has provided pharmaceutical formulations with tailored pharmacokinetic (PK) and…”
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Binary and ternary complexes of FLNa-Ig21 with cytosolic tails of αMß2 integrin reveal dual role of filamin mediated regulation by Zhiping, Lewis Lu, Ong, Li-Teng, Chatterjee, Deepak, Tan, Suet-Mien, Bhattacharjya, Surajit

“…Cytoskeletal protein filamin A is critical for the outside-in signaling of integrins. Although molecular mechanisms of filamin-integrin interactions are not…”
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WITHDRAWN: Diabetes mellitus due to toxic misfolding of proinsulin variants by Dhayalan, Balamurugan, Chatterjee, Deepak, Chen, Yen-Shan, Weiss, Michael A.

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Interaction Analyses of the Integrin β2 Cytoplasmic Tail with the F3 FERM Domain of Talin and 14-3-3ζ Reveal a Ternary Complex with Phosphorylated Tail by Chatterjee, Deepak, Zhiping, Lewis Lu, Tan, Suet-Mien, Bhattacharjya, Surajit

“…Integrins, which are heterodimeric (α and β subunits) signal-transducer proteins, are essential for cell adhesion and migration. β cytosolic tails (β-CTs) of…”
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Interaction Analyses of 14-3-3ζ, Dok1, and Phosphorylated Integrin β Cytoplasmic Tails Reveal a Bi-molecular Switch in Integrin Regulation by Chatterjee, Deepak, D’Souza, Areetha, Zhang, Yaming, Bin, Wu, Tan, Suet-Mien, Bhattacharjya, Surajit

“…Integrins are hetero-dimeric (α and β subunits) type I transmembrane proteins that facilitate cell adhesion and migration. The cytoplasmic tails (CTs) of…”
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Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone–receptor activation by Chen, Yen-Shan, Gleaton, Jeremy, Yang, Yanwu, Dhayalan, Balamurugan, Phillips, Nelson B., Liu, Yule, Broadwater, Laurie, Jarosinski, Mark A., Chatterjee, Deepak, Lawrence, Michael C., Hattier, Thomas, Michael, M. Dodson, Weiss, Michael A.

“…Insulin-signaling requires conformational change: whereas the free hormone and its receptor each adopt autoinhibited conformations, their binding leads to…”
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NMR Structure, Dynamics and Interactions of the Integrin β2 Cytoplasmic Tail with Filamin Domain IgFLNa21 by Chatterjee, Deepak, Zhiping, Lewis Lu, Tan, Suet-Mien, Bhattacharjya, Surajit

“…Integrins are transmembrane proteins that mediate cell adhesion and migration. Each integrin is a heterodimer formed by an α and a β subunit. A large number of…”
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Diabetes mellitus due to toxic misfolding of proinsulin variants by Dhayalan, Balamurugan, Chatterjee, Deepak, Chen, Yen-Shan, Weiss, Michael A

“…Dominant mutations in the human insulin gene (INS) lead to pancreatic β-cell dysfunction and diabetes mellitus (DM) due to toxic misfolding of a mutant…”
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Synthesis and structural studies of homooligomers of geminally disubstituted β(2,2)-amino acids with carbohydrate side chain by Sharma, Gangavaram V M, Reddy, Post Sai, Chatterjee, Deepak, Kunwar, Ajit C

“…A new class of geminally disubstituted C-linked carbo-β(2,2)-amino acids (β(2,2)-Caa) were prepared from d-glucose. The structures of homooligomeric di-,…”
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Synthesis of a new β-amino acid with a 3-deoxy-L-ara furnaoside side chain: the influence of the side chain on the conformation of α/β-peptides by Sharma, Gangavaram V M, Anjaiah, Gonuguntla, Kanakaraju, Marumudi, Sudhakar, Bommeda, Chatterjee, Deepak, Kunwar, Ajit C

“…The important role of side chains in the stabilization of helical folds in peptidic foldamers containing C-linked carbo-β-amino acids (β-Caa), an interesting…”
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Synthesis and Structural Studies of Homooligomers of Geminally Disubstituted β2,2-Amino Acids with Carbohydrate Side Chain by Sharma, Gangavaram V. M, Sai Reddy, Post, Chatterjee, Deepak, Kunwar, Ajit C

“…A new class of geminally disubstituted C-linked carbo-β2,2-amino acids (β2,2-Caa) were prepared from d-glucose. The structures of homooligomeric di-, tetra-,…”
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Investigation of folding patterns in homo-oligomers of (R)-I22,2-amino acids with carbohydrate side chain by Sharma, Gangavaram VM, Reddy, Post Sai, Chatterjee, Deepak, Kunwar, Ajit C

“…The study describes the synthesis of new I22,2-peptides made from geminally disubstituted I22,2-amino acid and their folding propensities. The (R)-C-linked…”
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Investigation of folding patterns in homo-oligomers of (R)-β2,2-amino acids with carbohydrate side chain by Sharma, Gangavaram V.M., Reddy, Post Sai, Chatterjee, Deepak, Kunwar, Ajit C.

“…The study describes the synthesis of new β2,2-peptides made from geminally disubstituted β2,2-amino acid and their folding propensities. The (R)-C-linked…”
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