Search Results - "Chasse, Dawn"

Meniscus gene expression profiling of inner and outer zone meniscus tissue compared to cartilage and passaged monolayer meniscus cells by Fei, Kaileen, Andress, Benjamin D., Kelly, A’nna M., Chasse, Dawn A. D., McNulty, Amy L.

“…Meniscus injuries are common and while surgical strategies have improved, there is a need for alternative therapeutics to improve long-term outcomes and…”
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Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore–microtubule attachment by Varma, Dileep, Chandrasekaran, Srikripa, Sundin, Lynsie J. R., Reidy, Karen T., Wan, Xiaohu, Chasse, Dawn A. D., Nevis, Kathleen R., DeLuca, Jennifer G., Salmon, E. D., Cook, Jeanette Gowen

“…Cdt1, a protein critical for replication origin licensing in G1 phase, is degraded during S phase but re-accumulates in G2 phase. We now demonstrate that human…”
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Oncogenic pathway signatures in human cancers as a guide to targeted therapies by Nevins, Joseph R, Bild, Andrea H, Yao, Guang, Chang, Jeffrey T, Wang, Quanli, Potti, Anil, Chasse, Dawn, Joshi, Mary-Beth, Harpole, David, Lancaster, Johnathan M, Berchuck, Andrew, Olson, John A, Marks, Jeffrey R, Dressman, Holly K, West, Mike

“…The development of an oncogenic state is a complex process involving the accumulation of multiple independent mutations that lead to deregulation of cell…”
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Optimization of Meniscus Cell Transduction Using Lentivirus and Adeno-Associated Virus for Gene Editing and Tissue Engineering Applications by Arrigoni, Paolo, Ruprecht, Jacob C., Chasse, Dawn A.D., Glass, Katherine A., Andress, Benjamin, Guilak, Farshid, Weinberg, J. Brice, McNulty, Amy L.

“…Objectives The utilization of viral vectors to deliver genes of interest directly to meniscus cells and promote long-term modulation of gene expression may…”
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Healthy but not osteoarthritic human meniscus-derived matrix scaffolds promote meniscus repair by Firoozi, Saman, Ley, Jon C., Chasse, Dawn A. D., Attarian, David E., Wellman, Samuel S., Amendola, Annunziato, McNulty, Amy L.

“…Meniscus tissue is commonly injured due to sports-related injuries and age-related degeneration and approximately 50% of individuals with a meniscus tear will…”
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The Regulated Association of Cdt1 with Minichromosome Maintenance Proteins and Cdc6 in Mammalian Cells by Cook, Jeanette Gowen, Chasse, Dawn A.D., Nevins, Joseph R.

“…Chromosomal DNA replication requires the recruitment of the six-subunit minichromosome maintenance (Mcm) complex to chromatin through the action of Cdc6 and…”
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Cross-platform prediction of gene expression signatures by Lin, Shu-Hong, Beane, Lauren, Chasse, Dawn, Zhu, Kevin W, Mathey-Prevot, Bernard, Chang, Jeffrey T

“…Gene expression signatures can predict the activation of oncogenic pathways and other phenotypes of interest via quantitative models that combine the…”
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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells by Sears, Rosalie, Yeh, Elizabeth, Cunningham, Melissa, Arnold, Hugh, Chasse, Dawn, Monteith, Teresa, Ivaldi, Giovanni, Hahn, William C, Stukenberg, P. Todd, Shenolikar, Shirish, Uchida, Takafumi, Counter, Christopher M, Nevins, Joseph R, Means, Anthony R

“…The stability of c-Myc is regulated by multiple Ras effector pathways. Phosphorylation at Ser 62 stabilizes c-Myc, whereas subsequent phosphorylation at Thr 58…”
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Abstract A24: The dual PI3K δ/γ inhibitor, RP6530, in combination with ibrutinib or fludarabine, synergistically enhances cytotoxicity in primary CLL cells in vitro by Vakkalanka, Swaroop, Penmetsa, Kumar V., Chasse, Dawn, Chen, Youwei, Viswanadha, Srikant, Friedman, Daphne R., Weinberg, J Brice

“…Abstract Background: The PI3K pathway is a central pro-survival mechanism in chronic lymphocytic leukemia (CLL). While the delta isoform of PI3K is largely…”
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Cross-Platform Prediction of Gene Expression Signatures: e79228 by Lin, Shu-Hong, Beane, Lauren, Chasse, Dawn, Zhu, Kevin W, Mathey-Prevot, Bernard, Chang, Jeffrey T

“…Gene expression signatures can predict the activation of oncogenic pathways and other phenotypes of interest via quantitative models that combine the…”
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Canine epidermolysis bullosa acquisita: circulating autoantibodies target the aminoterminal non-collagenous (NC1) domain of collagen VII in anchoring fibrils by OLIVRY, THIERRY, FINE, JO-DAVID, DUNSTON, STANLEY M., CHASSE, DAWN, TENORIO, AUREA PASCAL, MONTEIRO-RIVIERE, NANCY A., CHEN, MEI, WOODLEY, DAVID T.

“…The classification of autoimmune blistering skin diseases is based on the skin antigen(s) targeted by pathogenic autoantibodies. In humans and dogs, there is…”
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