Distribution of bone morphogenetic protein and bone morphogenetic protein receptor transcripts in the rodent nervous system and up-regulation of bone morphogenetic protein receptor type II in hippocampal dentate gyrus in a rat model of global cerebral ischemia

Bone morphogenetic proteins belong to the transforming growth factor-β superfamily and act through serine/threonine kinase type I and type II receptors such as bone morphogenetic protein receptor type I and type II. In order to further understand the roles that these factors exert in the nervous sys...

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Published in:	Neuroscience Vol. 100; no. 1; pp. 33 - 43
Main Authors:	Charytoniuk, D.A, Traiffort, E, Pinard, E, Issertial, O, Seylaz, J, Ruat, M
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-01-2000 Elsevier Elsevier - International Brain Research Organization
Subjects:	Animals Biological and medical sciences Bone Morphogenetic Protein Receptors Bone Morphogenetic Proteins Bone Morphogenetic Proteins - genetics Brain Ischemia Brain Ischemia - metabolism Cell physiology Dentate Gyrus Dentate Gyrus - metabolism dopaminergic Fundamental and applied biological sciences. Psychology growth factors Life Sciences Male Molecular and cellular biology motoneuron Nervous System Nervous System - metabolism Neurons and Cognition oligodendrocyte Protein Isoforms Protein Isoforms - metabolism Rats Rats, Wistar Receptors, Cell Surface Receptors, Cell Surface - genetics Receptors, Growth Factor Responses to growth factors, tumor promotors, other factors RNA, Messenger RNA, Messenger - metabolism Tissue Distribution Up-Regulation growth factors oligodendrocyte Act, activin receptor type BMPR, bone morphogenetic protein receptor TGF, transforming growth factor TH, tyrosine hydroxylase motoneuron ANOVA, analysis of variance CCA, common carotid artery PCR, polymerase chain reaction dopaminergic GDF, growth differentiating factors BMP, bone morphogenetic protein ISH, in situ hybridization RT-PCR, reverse transcript-polymerase chain reaction Rat Neuroglia Rodentia Central nervous system Motor neuron Vertebrata Dentate gyrus Mammalia Bone morphogenetic protein Ischemia Oligodendrocyte Distribution Hippocampus Brain (vertebrata) Growth factor Biological receptor
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Summary:	Bone morphogenetic proteins belong to the transforming growth factor-β superfamily and act through serine/threonine kinase type I and type II receptors such as bone morphogenetic protein receptor type I and type II. In order to further understand the roles that these factors exert in the nervous system, we have examined the expression pattern of seven bone morphogenetic proteins and bone morphogenetic protein receptor type I and II transcripts in the brain and spinal cord of rodent. Whereas bone morphogenetic protein receptor type I expression was low in rat brain, in situ hybridization studies performed with specific digoxigenin-labelled riboprobes revealed the presence of bone morphogenetic protein receptor type II-positive cells throughout the brain, with a notable localization in dopaminergic cells of the substantia nigra. Bone morphogenetic protein receptor type II transcripts were also expressed by large motoneuron-like cells located in the ventral horn of the spinal cord and by sensory neurons of dorsal root ganglia. In addition, we observed a significant up-regulation of bone morphogenetic protein receptor type II in the granule cells of the dentate gyrus 48 h after transient global cerebral ischemia in rat suggesting that modulation of this receptor intervenes during neuronal plasticity or repair that occur upon brain injury. Among the potential ligands for this receptor, bone morphogenetic protein-6 and bone morphogenetic protein-7 were expressed in meninges and the choroid plexus, while bone morphogenetic protein-4-expressing cells were spatially and temporally regulated in myelinated structures during development and in the adult suggesting its expression in oligodendrocytes. These data clearly indicate that besides their roles in bone and embryonic tissues, bone morphogenetic proteins and their receptors may have also important functions in adult neural tissues.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0306-4522 1873-7544
DOI:	10.1016/S0306-4522(00)00246-3