Search Results - "Charych, Deborah H"

Combination of radiation therapy, bempegaldesleukin, and checkpoint blockade eradicates advanced solid tumors and metastases in mice by Pieper, Alexander A, Rakhmilevich, Alexander L, Spiegelman, Daniel V, Patel, Ravi B, Birstler, Jen, Jin, Won Jong, Carlson, Peter M, Charych, Deborah H, Hank, Jacquelyn A, Erbe, Amy K, Overwijk, Willem W, Morris, Zachary S, Sondel, Paul M

“…BackgroundCurrent clinical trials are using radiation therapy (RT) to enhance an antitumor response elicited by high-dose interleukin (IL)-2 therapy or immune…”
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NKTR-214 immunotherapy synergizes with radiotherapy to stimulate systemic CD8+ T cell responses capable of curing multi-focal cancer by Walker, Joshua M, Rolig, Annah S, Charych, Deborah H, Hoch, Ute, Kasiewicz, Melissa J, Rose, Daniel C, McNamara, Michael J, Hilgart-Martiszus, Ian F, Redmond, William L

“…BackgroundHigh-dose radiotherapy (RT) is known to be immunogenic, but is rarely capable of driving clinically relevant abscopal antitumor immunity as…”
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Maximizing cancer therapy via complementary mechanisms of immune activation: PD-1 blockade, neoantigen vaccination, and Tregs depletion by D'Alise, Anna Morena, Leoni, Guido, De Lucia, Maria, Langone, Francesca, Nocchi, Linda, Tucci, Fabio Giovanni, Micarelli, Elisa, Cotugno, Gabriella, Troise, Fulvia, Garzia, Irene, Vitale, Rosa, Bignone, Veronica, Di Matteo, Elena, Bartolomeo, Rosa, Charych, Deborah H, Lahm, Armin, Zalevsky, Jonathan, Nicosia, Alfredo, Scarselli, Elisa

“…BackgroundA number of different immune pathways are involved in the effective killing of cancer cells, collectively named as the ‘Cancer Immunity Cycle’…”
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Reversible Color Switching and Unusual Solution Polymerization of Hydrazide-Modified Diacetylene Lipids by Jonas, Ulrich, Shah, Koonj, Norvez, Sophie, Charych, Deborah H

“…Layer systems composed of polydiacetylene lipids are known to undergo an irreversible colorimetric transition from blue to red upon exposure to an external…”
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NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models by Charych, Deborah H, Hoch, Ute, Langowski, John L, Lee, Steve R, Addepalli, Murali K, Kirk, Peter B, Sheng, Dawei, Liu, Xiaofeng, Sims, Paul W, VanderVeen, Laurie A, Ali, Cherie F, Chang, Thomas K, Konakova, Marina, Pena, Rhoneil L, Kanhere, Rupesh S, Kirksey, Yolanda M, Ji, Chunmei, Wang, Yujun, Huang, Jicai, Sweeney, Theresa D, Kantak, Seema S, Doberstein, Stephen K

“…Aldesleukin, recombinant human IL2, is an effective immunotherapy for metastatic melanoma and renal cancer, with durable responses in approximately 10% of…”
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Chain Length Dependence of the Frictional Properties of Alkylsilane Molecules Self-Assembled on Mica Studied by Atomic Force Microscopy by Xiao, Xudong, Hu, Jun, Charych, Deborah H, Salmeron, Miquel

“…We show that the frictional properties of alkylsilane monolayers self-assembled on mica in contact with Si3N4 tips depend strongly on the length of the alkyl…”
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Design and Synthesis of Novel Glycopolythiophene Assemblies for Colorimetric Detection of Influenza Virus and E. coli by Baek, Myung-Gi, Stevens, Raymond C, Charych, Deborah H

“…A novel family of glycopolythiophenes containing sialic acid or mannose ligands were prepared and evaluated for their ability to bind lectins, virus, and…”
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Direct Colorimetric Detection of a Receptor-Ligand Interaction by a Polymerized Bilayer Assembly by Charych, Deborah H., Nagy, Jon O., Spevak, Wayne, Bednarski, Mark D.

“…Detection of receptor-ligand interactions is generally accomplished by indirect assays such as enzyme-linked immunosorbent assay. A direct colorimetric…”
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Molecular Imaging of Thermochromic Carbohydrate-Modified Polydiacetylene Thin Films by Lio, Anna, Reichert, Anke, Ahn, Dong June, Nagy, Jon O, Salmeron, Miquel, Charych, Deborah H

“…Polymerized thin films based on polydiacetylenes (PDAs) undergo distinct color transitions that lend themselves to applications in biosensing, surface…”
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Application of (3-mercaptopropyl)trimethoxysilane as a molecular adhesive in the fabrication of vapor-deposited gold electrodes on glass substrates by Goss, Charles A, Charych, Deborah H, Majda, Marcin

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Solid Phase Immobilization of Optically Responsive Liposomes in Sol-Gel Materials for Chemical and Biological Sensing by Yamanaka, Stacey A, Charych, Deborah H, Loy, Douglas A, Sasaki, Darryl Y

“…Liposomes enhanced with surface recognition groups have previously been found to have high affinity for heavy metal ions and virus particles with unique…”
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Preparation, Structure, and Mechanical Stability of Alkylsilane Monolayers on Mica by Xiao, Xu-Dong, Liu, Gang-yu, Charych, Deborah H, Salmeron, Miquel

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Abstract 558: Durable antitumor activity of the CD122-biased immunostimulatory cytokine NKTR-214 combined with immune checkpoint blockade by Langowski, John L., Pena, Rhoneil, Kirksey, Yolanda M., Addepalli, Murali K., Hoch, Ute, Zalevsky, Jonathan, Doberstein, Stephen K., Charych, Deborah H.

“…Abstract Background: While immune checkpoint blockade is a promising therapeutic approach, combination with agents that modulate complementary pathways may…”
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Polymerized liposomes containing C-glycosides of sialic acid: potent inhibitors of influenza virus in vitro infectivity by Spevak, Wayne, Nagy, Jon O, Charych, Deborah H, Schaefer, Mary E, Gilbert, James H, Bednarski, Mark D

“…The surface lectin of the influenza virus, hemagglutinin, binds to terminal [alpha]-glycosides of N-acetylneuraminic acid (NeuAc) on cell-surface glycoproteins…”
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Carbohydrates in an Acidic Multivalent Assembly:  Nanomolar P-Selectin Inhibitors by Spevak, Wayne, Foxall, Carrol, Charych, Deborah H, Dasgupta, Falguni, Nagy, Jon O

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Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells by Charych, Deborah H., Coyne, Mazie, Yabannavar, Asha, Narberes, Jamie, Chow, Sylvia, Wallroth, Marco, Shafer, Cynthia, Walter, Annette O.

“…The Cdc7/Dbf4 kinase is required for initiation of DNA replication and also plays a role in checkpoint function in response to replication stress. Exactly how…”
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Incorporation of Unprotected Heterocyclic Side Chains into Peptoid Oligomers via Solid-Phase Submonomer Synthesis by Burkoth, Timothy S, Fafarman, Aaron T, Charych, Deborah H, Connolly, Michael D, Zuckermann, Ronald N

“…Peptoids (N-substituted glycines) are an important class of biomimetic oligomers that have made a significant impact in the areas of combinatorial drug…”
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Electrochemistry at the air/water interface. Lateral diffusion of an octadecylferrocene amphiphile in Langmuir monolayers by Charych, Deborah H, Landau, Ehud M, Majda, Marcin

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Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy by Sharma, Meenu, Khong, Hiep, Fa’ak, Faisal, Bentebibel, Salah-Eddine, Janssen, Louise M. E., Chesson, Brent C., Creasy, Caitlin A., Forget, Marie-Andrée, Kahn, Laura Maria S., Pazdrak, Barbara, Karki, Binisha, Hailemichael, Yared, Singh, Manisha, Vianden, Christina, Vennam, Srinivas, Bharadwaj, Uddalak, Tweardy, David J., Haymaker, Cara, Bernatchez, Chantale, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Hurwitz, Michael E., Sznol, Mario, Hwu, Patrick, Hoch, Ute, Addepalli, Murali, Charych, Deborah H., Zalevsky, Jonathan, Diab, Adi, Overwijk, Willem W.

“…High dose interleukin-2 (IL-2) is active against metastatic melanoma and renal cell carcinoma, but treatment-associated toxicity and expansion of suppressive…”
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Efficacy and immune modulation of the tumor microenvironment with the combination of the PARP inhibitor rucaparib and CD122-biased agonist NKTR-214 by Simmons, Andrew, Robillard, Liliane, Nguyen, Minh, Harding, Thomas C., Charych, Deborah H.

“…Abstract only…”
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