Search Results - "Charugundla, Sarada"

Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice by Zhang, Wenchao, Miikeda, Aika, Zuckerman, Jonathan, Jia, Xun, Charugundla, Sarada, Zhou, Zhiqiang, Kaczor-Urbanowicz, Karolina Elżbieta, Magyar, Clara, Guo, Fangfei, Wang, Zeneng, Pellegrini, Matteo, Hazen, Stanley L., Nicholas, Susanne B., Lusis, Aldons J., Shih, Diana M.

“…Patients with chronic kidney disease (CKD) have elevated circulating levels of trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and…”
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Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis[S] by Shih, Diana M., Wang, Zeneng, Lee, Richard, Meng, Yonghong, Che, Nam, Charugundla, Sarada, Qi, Hannah, Wu, Judy, Pan, Calvin, Brown, J. Mark, Vallim, Thomas, Bennett, Brian J., Graham, Mark, Hazen, Stanley L., Lusis, Aldons J.

“…We performed silencing and overexpression studies of flavin containing monooxygenase (FMO) 3 in hyperlipidemic mouse models to examine its effects on…”
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Sex differences in heart mitochondria regulate diastolic dysfunction by Cao, Yang, Vergnes, Laurent, Wang, Yu-Chen, Pan, Calvin, Chella Krishnan, Karthickeyan, Moore, Timothy M., Rosa-Garrido, Manuel, Kimball, Todd H., Zhou, Zhiqiang, Charugundla, Sarada, Rau, Christoph D., Seldin, Marcus M., Wang, Jessica, Wang, Yibin, Vondriska, Thomas M., Reue, Karen, Lusis, Aldons J.

“…Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more common in women than men, and we hypothesize that mitochondrial sex…”
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NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice by Guo, Fangfei, Seldin, Marcus, Péterfy, Miklós, Charugundla, Sarada, Zhou, Zhiqiang, Lee, Stephen D., Mouton, Alice, Rajbhandari, Prashant, Zhang, Wenchao, Pellegrini, Matteo, Tontonoz, Peter, Lusis, Aldons J., Shih, Diana M.

“…We recently showed that NOTUM, a liver-secreted Wnt inhibitor, can acutely promote browning of white adipose. We now report studies of chronic overexpression…”
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The genetic architecture of NAFLD among inbred strains of mice by Hui, Simon T, Parks, Brian W, Org, Elin, Norheim, Frode, Che, Nam, Pan, Calvin, Castellani, Lawrence W, Charugundla, Sarada, Dirks, Darwin L, Psychogios, Nikolaos, Neuhaus, Isaac, Gerszten, Robert E, Kirchgessner, Todd, Gargalovic, Peter S, Lusis, Aldons J

“…To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related…”
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Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice by Moore, Timothy M., Lee, Sindre, Olsen, Thomas, Morselli, Marco, Strumwasser, Alexander R., Lin, Amanda J., Zhou, Zhenqi, Abrishami, Aaron, Garcia, Steven M., Bribiesca, Jennifer, Cory, Kevin, Whitney, Kate, Ho, Theodore, Ho, Timothy, Lee, Joseph L., Rucker, Daniel H., Nguyen, Christina Q.A., Anand, Akshay T.S., Yackly, Aidan, Mendoza, Lorna Q., Leyva, Brayden K., Aliman, Claudia, Artiga, Daniel J., Meng, Yonghong, Charugundla, Sarada, Pan, Calvin, Jedian, Vida, Seldin, Marcus M., Ahn, In Sook, Diamante, Graciel, Blencowe, Montgomery, Yang, Xia, Mouisel, Etienne, Pellegrini, Matteo, Turcotte, Lorraine P., Birkeland, Kåre I., Norheim, Frode, Drevon, Christian A., Lusis, Aldons J., Hevener, Andrea L.

“…Physical activity is associated with beneficial adaptations in human and rodent metabolism. We studied over 50 complex traits before and after exercise…”
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Effect of 9p21.3 Coronary Artery Disease Locus Neighboring Genes on Atherosclerosis in Mice by KIM, Juyong Brian, DELUNA, Andres, CASTELLANI, Lawrence W, RUSEK, Marta, JAKOBOWSKI, Hieronim, LUSIS, Aldons J, MUNGRUE, Imran N, VU, Christine, POULDAR, Delila, CIVELEK, Mete, OROZCO, Luz, WU, Judy, XUPING WANG, CHARUGUNDLA, Sarada

“…The human 9p21.3 chromosome locus has been shown to be an independent risk factor for atherosclerosis in multiple large-scale genome-wide association studies,…”
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Apolipoprotein AII Is a Regulator of Very Low Density Lipoprotein Metabolism and Insulin Resistance by Castellani, Lawrence W., Nguyen, Cara N., Charugundla, Sarada, Weinstein, Michael M., Doan, Chau X., Blaner, William S., Wongsiriroj, Nuttaporn, Lusis, Aldons J.

“…Apolipoprotein AII (apoAII) transgenic (apoAIItg) mice exhibit several traits associated with the insulin resistance (IR) syndrome, including IR, obesity, and…”
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Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II by Castellani, Lawrence W., Gargalovic, Peter, Febbraio, Maria, Charugundla, Sarada, Jien, Ming-Len, Lusis, Aldons J.

“…We previously demonstrated that transgenic mice overexpressing mouse apolipoprotein A-II (apoA-II) exhibit several traits associated with the insulin…”
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Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure by Cao, Yang, Wang, Yuchen, Zhou, Zhenqi, Pan, Calvin, Jiang, Ling, Zhou, Zhiqiang, Meng, Yonghong, Charugundla, Sarada, Li, Tao, Allayee, Hooman, Seldin, Marcus M, Lusis, Aldons J

“…Tissue-tissue communication by endocrine factors is a vital mechanism for physiologic homeostasis. A systems genetics analysis of transcriptomic and functional…”
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Abstract 4141953: Genetic deficiency of flavin containing monooxygenase 3 ( Fmo3 ) lowers circulating trimethylamine N-oxide level and protects against atherosclerosis by Han, Maggie, Charugundla, Sarada, Wang, Zeneng, SINHA, Satyesh, Zhou, Zhiqiang, Allayee, Hooman, Hazen, Stanley, Lusis, Aldons, Shih, Diana

“…Abstract only Introduction: Our groups have previously identified trimethylamine N-oxide (TMAO) as a risk factor for cardiovascular diseases (CVD). In humans,…”
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Local M-CSF (Macrophage Colony-Stimulating Factor) Expression Regulates Macrophage Proliferation and Apoptosis in Atherosclerosis by Sinha, Satyesh K., Miikeda, Aika, Fouladian, Zachary, Mehrabian, Margarete, Edillor, Chantle, Shih, Diana, Zhou, Zhiqiang, Paul, Manash K., Charugundla, Sarada, Davis, Richard C., Rajavashisth, Tripathi B., Lusis, Aldons J.

“…OBJECTIVE:Previous studies have shown that deficiency of M-CSF (macrophage colony-stimulating factor; or CSF1 [colony stimulating factor 1]) dramatically…”
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Abstract 9832: Liver-Heart Crosstalk Mediated by Coagulation Factor XI Protects Against Heart Failure by Cao, Yang, Wang, Yuchen, Zhou, Zhenqi, Pan, Calvin, Jiang, Ling, Zhou, Zhiqiang, Meng, Yonghong, Charugundla, Sarada, Li, Tao, Allayee, Hooman, Seldin, Marcus, Lusis, Aldons J

“…IntroductionTissue-tissue crosstalk by endocrine factors is a vital mechanism to maintain proper physiologic homeostasis. The heart and the liver display…”
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Naked Mole‐Rat, a Rodent with an Apolipoprotein A‐I Dimer by Puppione, Don L., Tran, Denise P., Zenaidee, Muhammad A., Charugundla, Sarada, Whitelegge, Julian P., Buffenstein, Rochelle

“…A variety of rodents have been used as experimental animals in metabolic studies of plasma lipids and lipoproteins. These studies have included understanding…”
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Local macrophage colony-stimulating factor expression regulates macrophage proliferation and apoptosis in atherosclerosis by Sinha, Satyesh K., Miikeda, Aika, Fouladian, Zachary, Mehrabian, Margarete, Edillor, Chantle, Shih, Diana, Zhou, Zhiqiang, Paul, Manash K, Charugundla, Sarada, Davis, Richard C., Rajavashisth, Tripathi B., Lusis, Aldons J.

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Age‐induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge by Moore, Timothy M., Zhou, Zhenqi, Strumwasser, Alexander R., Cohn, Whitaker, Lin, Amanda J., Cory, Kevin, Whitney, Kate, Ho, Theodore, Ho, Timothy, Lee, Joseph L., Rucker, Daniel H., Hoang, Austin N., Widjaja, Kevin, Abrishami, Aaron D., Charugundla, Sarada, Stiles, Linsey, Whitelegge, Julian P., Turcotte, Lorraine P., Wanagat, Jonathan, Hevener, Andrea L.

“…Mitochondrial dysfunction is frequently associated with impairment in metabolic homeostasis and insulin action, and is thought to underlie cellular aging…”
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The effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice: Kim, Effect of 9p21.3 genes on atherosclerosis by Kim, Juyong Brian, Deluna, Andres, Mungrue, Imran N., Vu, Christine, Pouldar, Delila, Civelek, Mete, Orozco, Luz, Wu, Judy, Wang, Xuping, Charugundla, Sarada, Castellani, Lawrence W., Rusek, Marta, Jakobowski, Hieronim, Lusis, Aldons J.

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A microprecipitation technique suitable for measuring α‐lipoprotein cholesterol by Puppione, Donald L., Charugundla, Sarada

“…A semi‐automated method has been developed for determining α‐lipoprotein cholesterol values. Precipitation of apolipoprotein B containing lipoproteins takes…”
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