Search Results - "Chartoff, Elena H."

It's MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system by Chartoff, Elena H, Connery, Hilary S

“…Opioids selective for the G protein-coupled mu opioid receptor (MOR) produce potent analgesia and euphoria. Heroin, a synthetic opioid, is considered one of…”
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Early life stress disrupts social behavior and prefrontal cortex parvalbumin interneurons at an earlier time-point in females than in males by Holland, Freedom H., Ganguly, Prabarna, Potter, David N., Chartoff, Elena H., Brenhouse, Heather C.

“…•We examined divergent sex profiles in early-life stress (ELS) exposed rats.•ELS females showed social interaction deficits earlier in development than…”
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Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation by Carlezon, William A, Chartoff, Elena H

“…It has become increasingly important to assess mood states in laboratory animals. Tests that reflect reward, reduced ability to experience reward (anhedonia)…”
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Estrous cycle dependent expression of oxycodone conditioned reward in rats by Babb, Jessica A., Constantino, Nicholas J., Kaplan, Gary B., Chartoff, Elena H.

“…Oxycodone is one of the most widely prescribed and misused opioid painkillers in the United States. Evidence suggests that biological sex and hormonal status…”
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Gender differences in the prevalence of heroin and opioid analgesic misuse in the United States, 2015–2019 by McHugh, R. Kathryn, Nguyen, Minh D., Chartoff, Elena H., Sugarman, Dawn E., Greenfield, Shelly F.

“…•The gap between men and women in opioid misuse is shrinking.•Women are more likely than men to initiate misuse of opioid analgesics.•Men have a modestly…”
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Prolonged high fat diet reduces dopamine reuptake without altering DAT gene expression by Cone, Jackson J, Chartoff, Elena H, Potter, David N, Ebner, Stephanie R, Roitman, Mitchell F

“…The development of diet-induced obesity (DIO) can potently alter multiple aspects of dopamine signaling, including dopamine transporter (DAT) expression and…”
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Effects of an oxycodone conjugate vaccine on oxycodone self-administration and oxycodone-induced brain gene expression in rats by Pravetoni, Marco, Pentel, Paul R, Potter, David N, Chartoff, Elena H, Tally, Laura, LeSage, Mark G

“…Prescription opioid abuse is an increasing public health concern in the USA. A vaccine comprising a hapten (OXY) conjugated to the carrier protein keyhole…”
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Ranking the contribution of behavioral measures comprising oxycodone self-administration to reinstatement of drug-seeking in male and female rats by Guha, Suman K, Alonso-Caraballo, Yanaira, Driscoll, Gillian S, Babb, Jessica A, Neal, Megan, Constantino, Nicholas J, Lintz, Tania, Kinard, Elizabeth, Chartoff, Elena H

“…Rates of relapse to drug use during abstinence are among the highest for opioid use disorder (OUD). In preclinical studies, reinstatement to drug-seeking has…”
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Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue by Chartoff, Elena H, Papadopoulou, Maria, MacDonald, Matt L, Parsegian, Aram, Potter, David, Konradi, Christine, Carlezon, Jr, William A

“…The nucleus accumbens (NAc) is a critical brain area for reward and motivated behavior. Accumulating evidence suggests that altered function of the…”
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Sprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats by Dow, Antonia L, Lin, Tiffany V, Chartoff, Elena H, Potter, David, McPhie, Donna L, Van't Veer, Ashlee V, Knoll, Allison T, Lee, Kristen N, Neve, Rachael L, Patel, Tarun B, Ongur, Dost, Cohen, Bruce M, Carlezon, Jr, William A

“…Both the development and relief of stress-related psychiatric conditions such as major depression (MD) and post-traumatic stress disorder (PTSD) have been…”
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Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction by Chartoff, Elena H, Mavrikaki, Maria

“…Behavioral, biological, and social sequelae that lead to drug addiction differ between men and women. Our efforts to understand addiction on a mechanistic…”
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Microdosing of a kappa opioid receptor agonist within proximal nucleus accumbens shell microstructures revealing opposing behavioral outcomes by Rousseau, Erin B., Jackson, Hannah D., Guha, Suman, Sherman, Sydney S., Cima, Michael, Chartoff, Elena H.

“…•A method for delivery of potent and selective receptor agonists to very small regions of the brain.•The method can produce different behavior depending on…”
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The neurobiology of abstinence-induced reward-seeking in males and females by Alonso-Caraballo, Yanaira, Guha, Suman K., Chartoff, Elena H.

“…Drugs of abuse and highly palatable foods (e.g. high fat or sweet foods) have powerful reinforcing effects, which can lead to compulsive and addictive drives…”
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Females are less sensitive than males to the motivational- and dopamine-suppressing effects of kappa opioid receptor activation by Conway, Sineadh M., Puttick, Daniel, Russell, Shayla, Potter, David, Roitman, Mitchell F., Chartoff, Elena H.

“…The neuropeptide dynorphin (DYN) activates kappa opioid receptors (KORs) in the brain to produce depressive-like states and decrease motivation. KOR-mediated…”
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Translational Studies of Sex Differences in Sensitivity to Opioid Addiction by Chartoff, Elena H, McHugh, R Kathryn

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Sex Differences in Sensitivity to the Depressive-like Effects of the Kappa Opioid Receptor Agonist U-50488 in Rats by Russell, Shayla E, Rachlin, Anna B, Smith, Karen L, Muschamp, John, Berry, Loren, Zhao, Zhiyang, Chartoff, Elena H

“…Background Dynorphin, an endogenous ligand at kappa opioid receptors (KORs), produces depressive-like effects and contributes to addictive behavior in male…”
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Prenatal opioid exposure inhibits microglial sculpting of the dopamine system selectively in adolescent male offspring by Smith, Caroline J, Lintz, Tania, Clark, Madeline J, Malacon, Karen E, Abiad, Alia, Constantino, Nicholas J, Kim, Veronica J, Jo, Young C, Alonso-Caraballo, Yanaira, Bilbo, Staci D, Chartoff, Elena H

“…The current opioid epidemic has dramatically increased the number of children who are prenatally exposed to opioids, including oxycodone. A number of social…”
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Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats by Der-Avakian, Andre, D’Souza, Manoranjan S., Potter, David N., Chartoff, Elena H., Carlezon, William A., Pizzagalli, Diego A., Markou, Athina

“…Rationale Mood disorders can be triggered by stress and are characterized by deficits in reward processing, including disrupted reward learning (the ability to…”
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Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats by Page, Sarah, Mavrikaki, Maria M, Lintz, Tania, Puttick, Daniel, Roberts, Edward, Rosen, Hugh, Carroll, F Ivy, Carlezon, William A, Chartoff, Elena H

“…New treatments for stress-related disorders including depression, anxiety, and substance use disorder are greatly needed. Kappa opioid receptors are expressed…”
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Overexpression of miR-9 in the Nucleus Accumbens Increases Oxycodone Self-Administration by Mavrikaki, Maria, Anastasiadou, Eleni, Ozdemir, Recep A, Potter, David, Helmholz, Carolin, Slack, Frank J, Chartoff, Elena H

“…Abstract Background There is an urgent need to identify factors that increase vulnerability to opioid addiction to help stem the opioid epidemic and develop…”
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