Search Results - "Charris, Jaime E."

The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases by Martinez, Gricelis P, Zabaleta, Mercedes E, Di Giulio, Camilo, Charris, Jaime E, Mijares, Michael R

“…Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of the heterocyclic aromatic compound quinoline. These economical compounds have been used as…”
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Synthesis of Hybrid Molecules with Imidazole-1,3,4-thiadiazole Core and Evaluation of Biological Activity on Trypanosoma cruzi and Leishmania donovani by Mijoba, Ali, Parra-Giménez, Nereida, Fernandez-Moreira, Esteban, Ramírez, Hegira, Serrano, Xenón, Blanco, Zuleima, Espinosa, Sandra, Charris, Jaime E

“…The aim of this work was to obtain and evaluate, as antiprotozoals, new derivatives of benzoate imidazo-1,3,4-thiadiazole - based on the concepts of molecular…”
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Synthesis of Benzocycloalkanone-Based Michael Acceptors and Biological Activities as Antimalarial and Antitrypanosomal Agents by Mijoba, Ali, Fernandez-Moreira, Esteban, Parra-Giménez, Nereida, Espinosa-Tapia, Sandra, Blanco, Zuleyma, Ramírez, Hegira, Charris, Jaime E

“…A series of benzocycloalkanone derivatives have been prepared and evaluated as antimalarial and antitrypanosomal agents. The compounds were obtained by direct…”
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Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2 H )-one Derivatives by Blanco, Zuleima, Fernandez-Moreira, Esteban, Mijares, Michael R, Celis, Carmen, Martínez, Gricelis, De Sanctis, Juan B, Gurská, Soňa, Džubák, Petr, Hajdůch, Marián, Mijoba, Ali, García, Yael, Serrano, Xenón, Herrera, Nahum, Correa-Abril, Jhonny, Parra, Yonathan, Ángel, Jorge, Ramírez, Hegira, Charris, Jaime E

“…The coexistence of leishmaniasis, Chagas disease, and neoplasia in endemic areas has been extensively documented. The use of common drugs in the treatment of…”
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Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives by Gutiérrez, Joyce E, Ramírez, Hegira, Fernandez-Moreira, Esteban, Acosta, María E, Mijares, Michael R, De Sanctis, Juan Bautista, Gurská, Soňa, Džubák, Petr, Hajdúch, Marián, Labrador-Fagúndez, Liesangerli, Stella, Bruno G, Díaz-Pérez, Luis José, Benaim, Gustavo, Charris, Jaime E

“…A series of heterocyclic chloroquine hybrids, containing a chain of two carbon atoms at position four of the quinolinic chain and acting as a link between…”
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Synthesis and inhibitory activity of dimethylamino-chalcone derivatives on the induction of nitric oxide synthase by Rojas, Javier, Domı́nguez, José N, Charris, Jaime E, Lobo, Gricela, Payá, Miguel, Ferrándiz, M.Luisa

“…A series of nine dimethylamino-chalcone derivatives (1,3-diaryl-propenones) was synthesized and screened as potential inhibitors of NO and PGE 2 production in…”
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Synthesis and in silico ADME/Tox profiling studies of heterocyclic hybrids based on chloroquine scaffolds with potential antimalarial activity by Ramírez, Hegira, Fernandez-Moreira, Esteban, Rodrigues, Juan R., Mijares, Michael R., Ángel, Jorge E., Charris, Jaime E.

“…A series of heterocyclic chloroquine hybrids containing either a β-phenethylamine fragment or a 2-aminoindane moiety were synthesized and screened in vitro as…”
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In vitro evaluation and in vivo efficacy of nitroimidazole-sulfanyl ethyl derivatives against Leishmania (V.) braziliensis and Leishmania (L.) mexicana by Blanco, Zuleima, Mijares, Michael R., Ramírez, Hegira, Fernandez-Moreira, Esteban, Oviedo, Henry J., Rodríguez, Noris M., Charris, Jaime E.

“…The aim of this study was to synthesize several small molecules of the type 5-nitroimidazole-sulfanyl and evaluate biological properties against the main…”
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Optimization of antimalarial, and anticancer activities of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate by Romero, Jesús A., Acosta, María E., Gamboa, Neira D., Mijares, Michael R., De Sanctis, Juan B., Charris, Jaime E.

“…[Display omitted] •Compounds were easily synthesized.•Search for new antimalarial and anti-neoplastic drugs for the treatment of malaria and cancer…”
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Antimalarial, antiproliferative, and apoptotic activity of quinoline-chalcone and quinoline-pyrazoline hybrids. A dual action by Charris, Jaime E., Monasterios, Melina C., Acosta, María E., Rodríguez, Miguel A., Gamboa, Neira D., Martínez, Gricelis P., Rojas, Héctor R., Mijares, Michael R., De Sanctis, Juan B.

“…A series of quinoline-chalcone (E) -1-[3 or 4-(7-chloroquinolin-4-ylamino) phenyl]-3-(phenyl substituted) prop-2-ene-1-one ( 4 , 5 ), and quinoline-pyrazoline…”
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Synthesis of 5H‐indeno[1,2‐b]pyridine derivatives: Antiproliferative and antimetastatic activities against two human prostate cancer cell lines by Charris, Katiuska E., Rodrigues, Juan R., Ramírez, Hegira, Fernandez‐Moreira, Esteban, Ángel, Jorge E., Charris, Jaime E.

“…This study describes the direct synthesis of 2‐amino‐4‐(phenylsubstituted)‐5H‐indeno[1,2‐b]pyridine‐3‐carbonitrile derivatives 5–21, through sequential…”
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4-dimethylamino-3′,4′-dimethoxychalcone downregulates iNOS expression and exerts anti-inflammatory effects by Herencia, Felipe, Ferrándiz, Maria Luisa, Ubeda, Amalia, Guillén, Isabel, Dominguez, José N, Charris, Jaime E, Lobo, Gricela M, Alcaraz, Maria José

“…Reactive oxygen and nitrogen species contribute to the pathophysiology of inflammatory conditions. We have studied the effects of a novel superoxide scavenger,…”
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Optimization of the synthesis, in silico ADME/Tox profiling studies, and evaluation of the antimalarial activity of (7-chloroquinolin-4-ylthio)alkylbenzoate derivatives by Gutiérrez, Joyce E, Fernandez-Moreira, Esteban, Acosta, María E, Ramírez, Hegira, Charris, Jaime E

“…Optimized reaction conditions are developed to obtain a series of [(7-chloroquinolin-4-yl)sulfanyl] alcohol derivatives as intermediates to prepare a range of…”
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Synthesis, β-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei by Romero, Angel H., Acosta, María E., Gamboa, Neira, Charris, Jaime E., Salazar, José, López, Simón E.

“…[Display omitted] Diverse dehydroxy-isotebuquine derivatives were prepared by using a five step synthetic sequence in good yields. All these new…”
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Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives by Romero, Jesús A., Acosta, María E., Gamboa, Neira D., Mijares, Michael R., De Sanctis, Juan B., Llovera, Ligia J., Charris, Jaime E.

“…Twenty-eight compounds of the type N´-substituted-2-(5-nitroheterocyclic-2-yl)-3 H -benzo[d]imidazole-5-carboxamide were obtained using as an oxidizing agent…”
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Quinoline analogs of 2-aminoindane as potential central dopaminergic agents by Angel, Jorge E., Enriz, Ricardo D., Balza, Katherindel C., Angel, Ligia B., Perdomo, Luís E., Rodríguez, Lucia Ch, Dabian, Akram S., del C. Migliore, Biagina, Ramírez, María M., Ortega, José G., Charris, Jaime E., Israel, Anita, del R. Garrido, María, López, Simon E., Rojas, Sebastian, Andujar, Sebastian A.

“…Neurodegenerative disorders such as Parkinson and Huntington Chorea are related with damage to the central dopaminergic system. On the purpose to find new…”
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Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives by Barazarte, Arthur, Lobo, Gricela, Gamboa, Neira, Rodrigues, Juan R., Capparelli, Mario V., Álvarez-Larena, Ángel, López, Simón E., Charris, Jaime E.

“…A series of phenylsubstituted pyrazolo and pyrimido benzothiazine dioxide derivatives were synthesized and investigated for their abilities to inhibit…”
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Synthesis of quinolinyl chalcones and evaluation of their antimalarial activity by Domı́nguez, José N, Charris, Jaime E, Lobo, Gricela, Gamboa de Domı́nguez, Neira, Moreno, Marı́a M, Riggione, Flavia, Sanchez, Erlinda, Olson, Jed, Rosenthal, Philip J

“…Quinolinyl chalcones were synthesized and evaluated for their inhibition of the Plasmodium falciparum cystein protease falcipain and their activity against…”
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Synthesis and antimalarial activity of E-2-quinolinylbenzocycloalcanones by Charris, Jaime E., Domínguez, José N., Gamboa, Neira, Rodrigues, Juan R., Angel, Jorge E.

“…A series of E-2-quinolinylbenzocycloalcanones 5– 21 were prepared and evaluated for their activity to inhibit β-hematin formation and the hydrolysis of…”
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Synthesis and anti-inflammatory activity of chalcone derivatives by Herencia, Felipe, Ferrándiz, M.Luisa, Ubeda, Amalia, Domínguez, JoséN., Charris, Jaime E., Lobo, Gricela M., Alcaraz, M.José

“…Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited…”
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