Search Results - "Charmot, Dominique"

Non-systemic drugs: a critical review by Charmot, Dominique

“…Non-systemic drugs act within the intestinal lumen without reaching the systemic circulation. The first generation included polymeric resins that sequester…”
Get more information

Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform by Kozuka, Kenji, He, Ying, Koo-McCoy, Samantha, Kumaraswamy, Padmapriya, Nie, Baoming, Shaw, Karen, Chan, Priscilla, Leadbetter, Michael, He, Limin, Lewis, Jason G., Zhong, Ziyang, Charmot, Dominique, Balaa, Marwan, King, Andrew J., Caldwell, Jeremy S., Siegel, Matthew

“…We describe the development and characterization of a mouse and human epithelial cell monolayer platform of the small and large intestines, with a broad range…”
Get full text

Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans by Spencer, Andrew G, Labonte, Eric D, Rosenbaum, David P, Plato, Craig F, Carreras, Christopher W, Leadbetter, Michael R, Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Bell, Noah, Tabora, Jocelyn, Joly, Kristin M, Navre, Marc, Jacobs, Jeffrey W, Charmot, Dominique

“…The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an…”
Get more information

Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD by Labonté, Eric D., Carreras, Christopher W., Leadbetter, Michael R., Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Dy, Edward, Black, Deborah, Zhong, Ziyang, Langsetmo, Ingrid, Spencer, Andrew G., Bell, Noah, Deshpande, Desiree, Navre, Marc, Lewis, Jason G., Jacobs, Jeffrey W., Charmot, Dominique

Get full text

Preclinical and Healthy Volunteer Studies of Potential Drug–Drug Interactions Between Tenapanor and Phosphate Binders by Johansson, Susanne, Leonsson‐Zachrisson, Maria, Knutsson, Mikael, Spencer, Andrew G., Labonté, Eric D., Deshpande, Desiree, Kohler, Jill, Kozuka, Kenji, Charmot, Dominique, Rosenbaum, David P.

“…Tenapanor (RDX5791, AZD1722), a first‐in‐class small molecule with minimal systemic availability, is an inhibitor of the sodium/hydrogen exchanger isoform 3…”
Get full text

Gastrointestinal Inhibition of Sodium-Hydrogen Exchanger 3 Reduces Phosphorus Absorption and Protects against Vascular Calcification in CKD by Labonté, Eric D, Carreras, Christopher W, Leadbetter, Michael R, Kozuka, Kenji, Kohler, Jill, Koo-McCoy, Samantha, He, Limin, Dy, Edward, Black, Deborah, Zhong, Ziyang, Langsetmo, Ingrid, Spencer, Andrew G, Bell, Noah, Deshpande, Desiree, Navre, Marc, Lewis, Jason G, Jacobs, Jeffrey W, Charmot, Dominique

“…In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic cascade leading to hyperthyroidism, metabolic bone disease,…”
Get full text

Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5) by Chen, Tao, Reich, Nicholas William, Bell, Noah, Finn, Patricia D, Rodriguez, David, Kohler, Jill, Kozuka, Kenji, He, Limin, Spencer, Andrew G, Charmot, Dominique, Navre, Marc, Carreras, Christopher W, Koo-McCoy, Samantha, Tabora, Jocelyn, Caldwell, Jeremy S, Jacobs, Jeffrey W, Lewis, Jason Gustaf

“…Bile acid signaling and metabolism in the gastrointestinal tract have wide-ranging influences on systemic disease. G protein-coupled bile acid receptor 1…”
Get full text

Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3 by Jacobs, Jeffrey W., Leadbetter, Michael R., Bell, Noah, Koo-McCoy, Samantha, Carreras, Christopher W., He, Limin, Kohler, Jill, Kozuka, Kenji, Labonté, Eric D., Navre, Marc, Spencer, Andrew G., Charmot, Dominique

“…We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na+/H+ exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in…”
Get full text

The Safety, Tolerability, Systemic Exposure, and Effect on Bowel Habits of Single and Multiple Doses of the Intestinal Sodium Re-Uptake Inhibitor RDX5791 in Normal Healthy Volunteers: 1321 by Rosenbaum, David, Spencer, Andrew, Jacobs, Jeffrey, Charmot, Dominique

Get full text

Visceral Antinociceptive Effects of RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor on Stress-Induced Colorectal Hypersensitivity to Distension in Rats by Eutamene, Helene, Charmot, Dominique, Navre, Marc, Bueno, Lionel

Get full text

Modeling of Seeded Semibatch Emulsion Polymerization of n-BA by Plessis, Christophe, Arzamendi, Gurutze, Leiza, José R, Schoonbrood, Harold A. S, Charmot, Dominique, Asua, José M

“…A mathematical model for the computation of kinetics, branching frequency, sol molecular weight distribution, and gel fraction for the seeded semicontinuous…”
Get full text

Kinetics and Polymer Microstructure of the Seeded Semibatch Emulsion Copolymerization of n-Butyl Acrylate and Styrene by Plessis, Christophe, Arzamendi, Gurutze, Leiza, Jose R, Schoonbrood, Harold A. S, Charmot, Dominique, Asua, José M

“…The seeded semibatch emulsion polymerization of n-butyl acrylate, n-BA, with varying amounts of styrene as comonomer was investigated using potassium…”
Get full text

RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor in Clinical Development for CIC and IBS-C, Increases Intestinal Sodium Leading to Enhanced Intestinal Fluid Volume and Transit by Spencer, Andrew G, Jacobs, Jeffrey W, Leadbetter, Michael R, Carreras, Christopher W, Du, Xunxiang, Bell, Noah, Koo-McCoy, Samantha, Kohler, Jill N, Labonté, Eric, Rosenbaum, David P, Navre, Marc, Charmot, Dominique

Get full text

On-Line Monitoring of a Latex Emulsion Polymerization by Fiber-Optic FT-Raman Spectroscopy. Part I: Calibration by Bauer, Corinne, Amram, Bruno, Agnely, Mathias, Charmot, Dominique, Sawatzki, Jurgen, Dupuy, Nathalie, Huvenne, Jean-Pierre

“…The on-line monitoring of a styrene/butadiene latex emulsion polymerization was completed. Our aim was to determine in real time the dry extract percentage or…”
Get full text

Homeotic control in Drosophila; the scabrous gene is an in vivo target of Ultrabithorax proteins by Graba, Y, Aragnol, D, Laurenti, P, Garzino, V, Charmot, D, Berenger, H, Pradel, J

“…The regulatory functions of transcription factors encoded by the Ultrabithorax (Ubx) gene initiate genetic programmes essential for segmental identity and…”
Get full text

Seeded semibatch emulsion polymerization of butyl acrylate: Effect of the chain-transfer agent on the kinetics and structural properties by Plessis, Christophe, Arzamendi, Gurutze, Leiza, Jose R., Alberdi, Juan M., Schoonbrood, Harold A. S., Charmot, Dominique, Asua, Jose M.

“…The effect of dodecane‐1‐thiol on the kinetics, gel fraction, level of branches, and sol molecular weight distribution of the seeded semibatch emulsion…”
Get full text

Anti-interleukin 2 receptor monoclonal antibodies. Respective role of epitope mapping and monoclonal antibody-receptor interactions in their antagonist effects on interleukin 2-dependent T cell growth by Olive, D, Raymond, J, Dubreuil, P, Charmot, D, Jacques, Y, Mawas, C

“…Functional studies, using mainly interleukin 2 (IL2)-dependent growth of human T cell lines or clones but also mixed lymphocyte cultures and mitogen T cell…”
Get more information

Family studies define a new histocompatibility locus, SB , between HLA-DR and GLO by Shaw, Stephen, Kavathas, Paula, Pollack, Marilyn S, Charmot, Dominique, Mawas, Claude

Get full text

Secondary response of in vitro primed human lymphocytes to allogeneic cells: I. Role of HL-a antigens and mixed lymphocyte reaction stimulating determinants in secondary in vitro proliferative response by Mawas, Claude E., Charmot, Dominique, Sasportes, Maryline

Get full text

Specific Inhibition of Human Lymphocyte Responses by Primed Autologous Lymphocytes by Sheehy, Michael J., Mawas, Claude, Charmot, Dominique

“…Abstract Human lymphocytes from person A, primed for 10 to 14 days in MLC against lymphocytes from person B, inhibit specifically the proliferative response to…”
Get full text