IFN-tau: A novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities

IFN-tau: A novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities

IFN-tau (IFN-τ) constitutes a new class of type I IFN which is not virus-inducible, unlike IFN-α and IFN-β, but is constitutively produced by the trophectoderm of the ruminant conceptus during a very short period in early pregnancy. It plays a pivotal role in the mechanisms of maternal recognition o...

Full description

Saved in:
Bibliographic Details
Published in:Biochimie Vol. 80; no. 8; pp. 755 - 777
Main Authors: Martal, J.L., Chêne, N.M., Huynh, L.P., L'Haridon, R.M., Reinaud, P.B., Guillomot, M.W., Charlier, M.A., Charpigny, S.Y.
Format: Journal Article
Language:English
Published: France Elsevier Masson SAS 01-08-1998
Elsevier
Subjects:
AIDS/HIV
Animals
embryo
evolution
Female
Gene Expression
HIV
Hormones - chemistry
Hormones - physiology
Human immunodeficiency virus
Humans
IFN-τ
Interferon Type I - chemistry
Interferon Type I - genetics
Interferon Type I - physiology
interferons
Life Sciences
multiple sclerosis
oTP-1
Pregnancy
Pregnancy Proteins - chemistry
Pregnancy Proteins - genetics
Pregnancy Proteins - physiology
Pregnancy, Animal - physiology
Receptors, Interferon - physiology
Ruminantia
Ruminants
Signal Transduction
structure-function
trophoblastin
Ubiquitins
interferons
HIV
multiple sclerosis
trophoblastin
pregnancy
structure-function
embryo
evolution
oTP-1
IFN-τ
STRUCTURE-ACTIVITE
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:IFN-tau (IFN-τ) constitutes a new class of type I IFN which is not virus-inducible, unlike IFN-α and IFN-β, but is constitutively produced by the trophectoderm of the ruminant conceptus during a very short period in early pregnancy. It plays a pivotal role in the mechanisms of maternal recognition of pregnancy in ruminants and it displays high antiviral and antiproliferative activities across species with a prominent lack of cytotoxicity at high concentrations in vitro in cell culture and possibly in vivo. It exhibits high antiretroviral activity against HIV and exhibits immunosuppressive activity in a multiple sclerosis model and reduces embryo and fetal mortality by stimulation of IL-10 production. In this review all the biochemical and para-hormonal properties of this novel IFN-τ are described in detail: structural characteristics of proteins and genes, trophoblast expression, regulation of its expression, structure of its gene promoter, its absence in human species and in non-ruminant animals, the evolution of the IFN-τ genes, its structure-function relationships with its three-dimensional structure, structural localization of biological activities, its lack of cytotoxicity and its receptor. Surprisingly, for an IFN, IFN-τ is also a pregnancy-embryonic signal with paracrine antiluteolytic activity. In order to maintain luteal progesterone secretion, IFN-τ inhibits PGF-2α pulsatile secretion and oxytocin uterine receptivity in early pregnancy. It is believed to suppress pulsatile release of endometrial PGF-2α by preventing oxytocin and estrogen receptor expression. Additionally, it directly regulates prostaglandin metabolism and possibly the PGE:PGF-2α ratio.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0300-9084
1638-6183
DOI:10.1016/S0300-9084(99)80029-7