Search Results - "Charles B. Stauft"

Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions by Song, Yutong, Mugavero, JoAnn, Stauft, Charles B, Wimmer, Eckard

“…The genus of the family encompasses numerous enveloped plus-strand RNA viruses. Dengue virus (DENV), a flavivirus, is the leading cause of serious…”
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HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters by Jana, Sirsendu, Heaven, Michael R, Stauft, Charles B, Wang, Tony T, Williams, Matthew C, D'Agnillo, Felice, Alayash, Abdu I

“…The mechanistic interplay between SARS-CoV-2 infection, inflammation, and oxygen homeostasis is not well defined. Here, we show that the hypoxia-inducible…”
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Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference by Shen, Sam H., Stauft, Charles B., Gorbatsevych, Oleksandr, Song, Yutong, Ward, Charles B., Yurovsky, Alisa, Mueller, Steffen, Futcher, Bruce, Wimmer, Eckard

“…The protein synthesis machineries of two distinct phyla of the Animal kingdom, insects of Arthropoda and mammals of Chordata, have different preferences for…”
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Effects of N-glycan modifications on spike expression, virus infectivity, and neutralization sensitivity in ancestral compared to Omicron SARS-CoV-2 variants by Lusvarghi, Sabrina, Stauft, Charles B, Vassell, Russell, Williams, Brittany, Baha, Haseebullah, Wang, Wei, Neerukonda, Sabari Nath, Wang, Tony, Weiss, Carol D

“…The SARS-CoV-2 spike glycoprotein has 22 potential N-linked glycosylation sites per monomer that are highly conserved among diverse variants, but how…”
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Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants by Stauft, Charles B., Selvaraj, Prabhuanand, D’Agnillo, Felice, Meseda, Clement A., Liu, Shufeng, Pedro, Cyntia L., Sangare, Kotou, Lien, Christopher Z., Weir, Jerry P., Starost, Matthew F., Wang, Tony T.

“…Detection of secretory antibodies in the airway is highly desirable when evaluating mucosal protection by vaccines against a respiratory virus, such as the…”
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Live-attenuated H1N1 influenza vaccine candidate displays potent efficacy in mice and ferrets by Stauft, Charles B, Yang, Chen, Coleman, J Robert, Boltz, David, Chin, Chiahsuan, Kushnir, Anna, Mueller, Steffen

“…Currently, influenza vaccine manufacturers need to produce 1-5 x 107 PFU of each vaccine strain to fill one dose of the current…”
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Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters by Liu, Shufeng, Stauft, Charles B., Selvaraj, Prabhuanand, Chandrasekaran, Prabha, D’Agnillo, Felice, Chou, Chao-Kai, Wu, Wells W., Lien, Christopher Z., Meseda, Clement A., Pedro, Cyntia L., Starost, Matthew F., Weir, Jerry P., Wang, Tony T.

“…Few live attenuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are in pre-clinical or clinical development. We seek to attenuate…”
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Identification of salivary gland escape barriers to western equine encephalitis virus in the natural vector, Culex tarsalis by Stauft, Charles B, Phillips, Aaron T, Wang, Tony T, Olson, Kenneth E

“…Herein we describe a previously uninvestigated salivary gland escape barrier (SEB) in Culex tarsalis mosquitoes infected with two different strains of Western…”
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Selective Targeting of Virus Replication by Proton Pump Inhibitors by Watanabe, Susan M., Ehrlich, Lorna S., Strickland, Madeleine, Li, Xiaofan, Soloveva, Veronica, Goff, Arthur J., Stauft, Charles B., Bhaduri-McIntosh, Sumita, Tjandra, Nico, Carter, Carol

“…Two proton pump inhibitors, tenatoprazole and esomeprazole, were previously shown to inhibit HIV-1 egress by blocking the interaction between Tsg101, a member…”
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Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes by Stauft, Charles B, Shen, Sam H, Song, Yutong, Gorbatsevych, Oleksandr, Asare, Emmanuel, Futcher, Bruce, Mueller, Steffen, Payne, Anne, Brecher, Matthew, Kramer, Laura, Wimmer, Eckard

“…Dengue virus (DENV), an arthropod-borne ("arbovirus") virus, causes a range of human maladies ranging from self-limiting dengue fever to the life-threatening…”
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Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern by Tang, Juanjie, Lee, Youri, Ravichandran, Supriya, Grubbs, Gabrielle, Huang, Chang, Stauft, Charles B., Wang, Tony, Golding, Basil, Golding, Hana, Khurana, Surender

“…Hyperimmune immunoglobulin (hCoV-2IG) generated from SARS-CoV-2 convalescent plasma (CP) are under evaluation in clinical trials. Here we explored the antibody…”
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Reply to Simmonds et al: Codon pair and dinucleotide bias have not been functionally distinguished by Futcher, Bruce, Gorbatsevych, Oleksandr, Shen, Sam H., Stauft, Charles B., Song, Yutong, Wang, Bingyin, Leatherwood, Janet, Gardin, Justin, Yurovsky, Alisa, Mueller, Steffen, Wimmer, Eckard

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SARS-CoV-2 B.1.1.7 Infection of Syrian Hamster Does Not Cause More Severe Disease, and Naturally Acquired Immunity Confers Protection by Nuñez, Ivette A, Lien, Christopher Z, Selvaraj, Prabhuanand, Stauft, Charles B, Liu, Shufeng, Starost, Matthew F, Wang, Tony T

“…Epidemiological studies have revealed the emergence of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC),…”
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Bioluminescent imaging and histopathologic characterization of WEEV neuroinvasion in outbred CD-1 mice by Phillips, Aaron T, Stauft, Charles B, Aboellail, Tawfik A, Toth, Ann M, Jarvis, Donald L, Powers, Ann M, Olson, Ken E

“…Western equine encephalitis virus (WEEV; Alphavirus) is a mosquito-borne virus that can cause severe encephalitis in humans and equids. Previous studies have…”
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MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge by Meseda, Clement A., Stauft, Charles B., Selvaraj, Prabhuanand, Lien, Christopher Z., Pedro, Cyntia, Nuñez, Ivette A., Woerner, Amy M., Wang, Tony T., Weir, Jerry P.

“…Numerous vaccine candidates against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are under development. The majority of vaccine candidates to date…”
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Differences in New Variant of Concern Replication at Physiological Temperatures In Vitro by Stauft, Charles B, Sangare, Kotou, Wang, Tony T

“…Abstract Using multiple cell types and isolates of Delta and Omicron variants of SARS-CoV-2, we report differences in virus production, replication, and…”
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A codon-pair deoptimized live-attenuated vaccine against respiratory syncytial virus is immunogenic and efficacious in non-human primates by Mueller, Steffen, Stauft, Charles B., Kalkeri, Raj, Koidei, Fusataka, Kushnir, Anna, Tasker, Sybil, Coleman, J. Robert

“…Despite a critical need for a respiratory syncytial virus (RSV) vaccine and decades of development efforts, a vaccine to protect infants, elderly, and other…”
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Structure–Function Analysis of Resistance to Bamlanivimab by SARS-CoV‑2 Variants Kappa, Delta, and Lambda by Liu, Shufeng, Huynh, Tien, Stauft, Charles B, Wang, Tony T, Luan, Binquan

“…The newly emerging Kappa, Delta, and Lambda SARS-CoV-2 variants are worrisome, characterized with the double mutations E484Q/L452R, T478K/L452R, and…”
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Pharmacokinetics and Efficacy of Human Hyperimmune Intravenous Immunoglobulin Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Adult Syrian Hamsters by Stauft, Charles B, Tegenge, Million, Khurana, Surender, Lee, Youri, Selvaraj, Prabhuanand, Golding, Hana, Wang, Tony, Golding, Basil

“…Abstract Background After the failure of antibody therapies in treating hospitalized patients with coronavirus disease 2019 (COVID-19), we investigated the…”
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Vaccine-associated respiratory pathology correlates with viral clearance and protective immunity after immunization with self-amplifying RNA expressing the spike (S) protein of SARS-CoV-2 in mouse models by Kachko, Alla, Selvaraj, Prabhuanand, Liu, Shufeng, Kim, Jaekwan, Rotstein, David, Stauft, Charles B., Chabot, Sylvie, Rajasagi, Naveen, Zhao, Yangqing, Wang, Tony, Major, Marian

“…•saRNA vaccines for SARS-CoV-2: Protection & Pathology in mice.•Post-challenge lung pathology in vaccinated mice linked to T- and B-cell infiltration.•T-cell…”
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