Search Results - "Charles, Sandy"
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Spatial patterns of pulmonary tuberculosis (TB) cases in Zimbabwe from 2015 to 2018
Published in PloS one (08-04-2021)“…Accurate mapping of spatial heterogeneity in tuberculosis (TB) cases is critical for achieving high impact control as well as guide resource allocation in most…”
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Tuberculosis cohort analysis in Zimbabwe: The need to strengthen patient follow-up throughout the tuberculosis care cascade
Published in PloS one (08-11-2023)“…Introduction Globally people with tuberculosis (TB) continue to be missed each year. They are either not diagnosed or not reported which indicates possible…”
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Treatment outcomes of multi drug resistant and rifampicin resistant Tuberculosis in Zimbabwe: A cohort analysis of patients initiated on treatment during 2010 to 2015
Published in PloS one (30-04-2020)“…Zimbabwe is one of the thirty countries globally with a high burden of multidrug-resistant tuberculosis (TB) or rifampicin-resistant TB (MDR/RR-TB). Since…”
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Prevalence of de novo aortic insufficiency during long-term support with left ventricular assist devices
Published in The Journal of heart and lung transplantation (01-10-2010)“…Background Left ventricular assist devices (LVADs) are increasingly used as long-term therapy for end-stage heart failure patients. We compared the prevalence…”
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Prevalence of drug-resistant tuberculosis in Zimbabwe: A health facility-based cross-sectional survey
Published in International journal of infectious diseases (01-10-2019)“…•The prevalence of RR-TB was [4.0% (95% CI, 2.9, 5.4%) and 14.2% (95% CI, 8.9, 21.1%)] among new and retreatment patients, respectively.•The prevalence of…”
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Integrating 3HP‐based tuberculosis preventive treatment into Zimbabwe's Fast Track HIV treatment model: experiences from a pilot study
Published in Journal of the International AIDS Society (01-06-2023)“…Introduction Tuberculosis (TB) causes one‐third of HIV‐related deaths worldwide, making TB preventive treatment (TPT) a critical element of HIV programmes…”
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Access to second-line drug susceptibility testing results among patients with Rifampicin resistant tuberculosis after introduction of the Hain® Line Probe Assay in Southern provinces, Zimbabwe
Published in International journal of infectious diseases (01-04-2019)“…•95% of patients started a standard MDR-TB regimen while 6(5%) had pre-treatment attrition.•91% of the patients were initiated on treatment within a week.•Only…”
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Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs
Published in Nucleic acids research (01-02-2013)“…The RNA-binding protein AUF1 binds AU-rich elements in 3'-untranslated regions to regulate mRNA degradation and/or translation. Many of these mRNAs are…”
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Early risk assessment in paediatric and adult household contacts of confirmed tuberculosis cases by novel diagnostic tests (ERASE-TB): protocol for a prospective, non-interventional, longitudinal, multicountry cohort study
Published in BMJ open (19-07-2022)“…IntroductionThe WHO End-TB Strategy calls for the development of novel diagnostics to detect tuberculosis (TB) earlier and more accurately. Better diagnostics,…”
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Operational Research to Assess the Real-Time Impact of COVID-19 on TB and HIV Services: The Experience and Response from Health Facilities in Harare, Zimbabwe
Published in Tropical medicine and infectious disease (31-05-2021)“…When COVID-19 was declared a pandemic, there was concern that TB and HIV services in Zimbabwe would be severely affected. We set up real-time monthly…”
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Drug-resistant tuberculosis in high-risk groups, Zimbabwe
Published in Emerging infectious diseases (01-01-2014)“…To estimate prevalence of multidrug-resistant tuberculosis (MDR TB) in Harare, Zimbabwe, in 2012, we performed microbiologic testing on acid-fast bacilli…”
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Evidence to Action: Translating Innovations in Management of Child and Adolescent TB into Routine Practice in High-Burden Countries
Published in Pathogens (Basel) (23-03-2022)“…Child and adolescent tuberculosis (TB) has been long neglected by TB programs but there have been substantive strides in prioritizing TB among these…”
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Coverage and effectiveness of conditional cash transfer for people with drug resistant tuberculosis in Zimbabwe: A mixed methods study
Published in PLOS global public health (2022)“…The End TB strategy recommends social protection to mitigate socio-economic impacts of tuberculosis. Zimbabwe started implementing a conditional cash transfer…”
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Declining Trends in Childhood TB Notifications and Profile of Notified Patients in the City of Harare, Zimbabwe, from 2009 to 2018
Published in Journal of tropical medicine (2020)“…Globally, childhood tuberculosis (TB among those aged <15 years) is a neglected component of national TB programmes in high TB burden countries. Zimbabwe, a…”
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Treatment outcomes of adult patients with recurrent tuberculosis in relation to HIV status in Zimbabwe: a retrospective record review
Published in BMC public health (13-02-2012)“…Zimbabwe is a Southern African country with a high HIV-TB burden and is ranked 19th among the 22 Tuberculosis high burden countries worldwide. Recurrent TB is…”
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Clinical and radiologic characteristics of the imploding antrum, or "silent sinus," syndrome
Published in Ophthalmology (Rochester, Minn.) (01-04-2003)“…To present the clinical and radiologic details of a series of patients with the imploding antrum, or silent sinus, syndrome, together with examples of the…”
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Characteristics and treatment outcomes of tuberculosis patients who "transfer-in" to health facilities in Harare City, Zimbabwe: a descriptive cross-sectional study
Published in BMC public health (15-11-2012)“…Zimbabwe is among the 22 Tuberculosis (TB) high burden countries worldwide and runs a well-established, standardized recording and reporting system on case…”
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Targeted Knockdown of the RNA-binding Protein CRD-BP Promotes Cell Proliferation via an Insulin-like Growth Factor II-dependent Pathway in Human K562 Leukemia Cells
Published in The Journal of biological chemistry (19-11-2004)“…The c- myc mRNA coding region determinant-binding protein (CRD-BP) was first identified as a masking protein that stabilizes c- myc mRNA in a cell-free mRNA…”
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Factors Associated with Mortality among Patients on TB Treatment in the Southern Region of Zimbabwe, 2013
Published in Tuberculosis research and treatment (01-01-2017)“…Background. In 2013, the tuberculosis (TB) mortality rate was highest in southern Zimbabwe at 16%. We therefore sought to determine factors associated with…”
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Spatial patterns of pulmonary tuberculosis
Published in PloS one (08-04-2021)“…Introduction Accurate mapping of spatial heterogeneity in tuberculosis (TB) cases is critical for achieving high impact control as well as guide resource…”
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Journal Article