Search Results - "Charles, M. W."

The SWI/SNF complex in cancer — biology, biomarkers and therapy by Mittal, Priya, Roberts, Charles W. M.

“…Cancer genome-sequencing studies have revealed a remarkably high prevalence of mutations in genes encoding subunits of the SWI/SNF chromatin-remodelling…”
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SWI/SNF nucleosome remodellers and cancer by Roberts, Charles W. M, Wilson, Boris G

“…Key Points Specific inactivating mutations in subunits of SWI/SNF chromatin remodelling complexes, including the SNF5 (also known as SMARCB1, INI1 and BAF47),…”
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Molecular Pathways: SWI/SNF (BAF) Complexes Are Frequently Mutated in Cancer—Mechanisms and Potential Therapeutic Insights by XIAOFENG WANG, HASWELL, Jeffrey R, ROBERTS, Charles W. M

“…SWI/SNF chromatin remodeling complexes are pleomorphic multisubunit cellular machines that utilize the energy of ATP hydrolysis to modulate chromatin…”
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Chromatin remodellers as therapeutic targets by Malone, Hayden A., Roberts, Charles W. M.

“…Large-scale cancer genome sequencing studies have revealed that chromatin regulators are frequently mutated in cancer. In particular, more than 20% of cancers…”
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ARID1B is a specific vulnerability in ARID1A-mutant cancers by Helming, Katherine C, Wang, Xiaofeng, Wilson, Boris G, Vazquez, Francisca, Haswell, Jeffrey R, Manchester, Haley E, Kim, Youngha, Kryukov, Gregory V, Ghandi, Mahmoud, Aguirre, Andrew J, Jagani, Zainab, Wang, Zhong, Garraway, Levi A, Hahn, William C, Roberts, Charles W M

“…Mutations inactivating ARID1A, a subunit of the chromatin remodeling SWI/SNF complex, have been identified in some human cancers. This study reveals that…”
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Author Correction: Developmental origins shape the paediatric cancer genome by Chen, Xiaolong, Yang, Wentao, Roberts, Charles W. M., Zhang, Jinghui

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BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors by Wang, Xiaofeng, Wang, Su, Troisi, Emma C., Howard, Thomas P., Haswell, Jeffrey R., Wolf, Bennett K., Hawk, William H., Ramos, Pilar, Oberlick, Elaine M., Tzvetkov, Evgeni P., Ross, Aaron, Vazquez, Francisca, Hahn, William C., Park, Peter J., Roberts, Charles W. M.

“…Bromodomain-containing protein 9 (BRD9) is a recently identified subunit of SWI/SNF(BAF) chromatin remodeling complexes, yet its function is poorly understood…”
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The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers by Alver, Burak H., Kim, Kimberly H., Lu, Ping, Wang, Xiaofeng, Manchester, Haley E., Wang, Weishan, Haswell, Jeffrey R., Park, Peter J., Roberts, Charles W. M.

“…Genes encoding subunits of SWI/SNF (BAF) chromatin remodelling complexes are collectively altered in over 20% of human malignancies, but the mechanisms by…”
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Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation by Wilson, Boris G., Helming, Katherine C., Wang, Xiaofeng, Kim, Youngha, Vazquez, Francisca, Jagani, Zainab, Hahn, William C., Roberts, Charles W. M.

“…Classifications Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Developmental origins shape the paediatric cancer genome by Chen, Xiaolong, Yang, Wentao, Roberts, Charles W. M., Zhang, Jinghui

“…In the past two decades, technological advances have brought unprecedented insights into the paediatric cancer genome revealing characteristics distinct from…”
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Mutational processes shape the landscape of TP53 mutations in human cancer by Giacomelli, Andrew O., Yang, Xiaoping, Lintner, Robert E., McFarland, James M., Duby, Marc, Kim, Jaegil, Howard, Thomas P., Takeda, David Y., Ly, Seav Huong, Kim, Eejung, Gannon, Hugh S., Hurhula, Brian, Sharpe, Ted, Goodale, Amy, Fritchman, Briana, Steelman, Scott, Vazquez, Francisca, Tsherniak, Aviad, Aguirre, Andrew J., Doench, John G., Piccioni, Federica, Roberts, Charles W. M., Meyerson, Matthew, Getz, Gad, Johannessen, Cory M., Root, David E., Hahn, William C.

“…Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein p53 (TP53) are missense mutations 1 , 2 . Mutant p53 protein is often…”
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SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation by Wang, Xiaofeng, Lee, Ryan S, Alver, Burak H, Haswell, Jeffrey R, Wang, Su, Mieczkowski, Jakub, Drier, Yotam, Gillespie, Shawn M, Archer, Tenley C, Wu, Jennifer N, Tzvetkov, Evgeni P, Troisi, Emma C, Pomeroy, Scott L, Biegel, Jaclyn A, Tolstorukov, Michael Y, Bernstein, Bradley E, Park, Peter J, Roberts, Charles W M

“…Charles Roberts, Peter Park, Bradley Bernstein and colleagues examine the consequences of SMARCB1 loss on enhancer landscapes in human rhabdoid tumors. They…”
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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma by Perry, Jennifer A, Kiezun, Adam, Tonzi, Peter, Van Allen, Eliezer M, Carter, Scott L, Baca, Sylvan C, Cowley, Glenn S, Bhatt, Ami S, Rheinbay, Esther, Pedamallu, Chandra Sekhar, Helman, Elena, Taylor-Weiner, Amaro, McKenna, Aaron, DeLuca, David S, Lawrence, Michael S, Ambrogio, Lauren, Sougnez, Carrie, Sivachenko, Andrey, Walensky, Loren D, Wagle, Nikhil, Mora, Jaume, de Torres, Carmen, Lavarino, Cinzia, Dos Santos Aguiar, Simone, Yunes, Jose Andres, Brandalise, Silvia Regina, Mercado-Celis, Gabriela Elisa, Melendez-Zajgla, Jorge, Cárdenas-Cardós, Rocío, Velasco-Hidalgo, Liliana, Roberts, Charles W M, Garraway, Levi A, Rodriguez-Galindo, Carlos, Gabriel, Stacey B, Lander, Eric S, Golub, Todd R, Orkin, Stuart H, Getz, Gad, Janeway, Katherine A

“…Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59…”
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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers by Hoffman, Gregory R., Rahal, Rami, Buxton, Frank, Xiang, Kay, McAllister, Gregory, Frias, Elizabeth, Bagdasarian, Linda, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris G., Meyer, Matthew J., Saenz-Vash, Veronica, Zhai, Huili, Myer, Vic E., Porter, Jeffrey A., Keen, Nicholas, McLaughlin, Margaret E., Mickanin, Craig, Roberts, Charles W. M., Stegmeier, Frank, Jagani, Zainab

“…Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic…”
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Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters by Tolstorukov, Michael Y., Sansam, Courtney G., Lu, Ping, Koellhoffer, Edward C., Helming, Katherine C., Alver, Burak H., Tillman, Erik J., Evans, Julia A., Wilson, Boris G., Park, Peter J., Roberts, Charles W. M.

“…Precise nucleosome-positioning patterns at promoters are thought to be crucial for faithful transcriptional regulation. However, the mechanisms by which these…”
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Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity by Yin, Jie, Leavenworth, Jianmei W., Li, Yang, Luo, Qi, Xie, Huafeng, Liu, Xinhua, Huang, Shan, Yan, Han, Fu, Zheng, Zhang, Liyun Y., Zhang, Litao, Hao, Junwei, Wu, Xudong, Deng, Xianming, Roberts, Charles W. M., Orkin, Stuart H., Cantor, Harvey, Wang, Xi

“…Changes of histone modification status at critical lineage-specifying gene loci in multipotent precursors can influence cell fate commitment. The contribution…”
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PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression by Mittal, Priya, Myers, Jacquelyn A., Carter, Raymond D., Radko-Juettner, Sandi, Malone, Hayden A., Rosikiewicz, Wojciech, Robertson, Alexis N., Zhu, Zhexin, Narayanan, Ishwarya V., Hansen, Baranda S., Parrish, Meadow, Bhanu, Natarajan V., Mobley, Robert J., Rehg, Jerold E., Xu, Beisi, Drosos, Yiannis, Pruett-Miller, Shondra M., Ljungman, Mats, Garcia, Benjamin A., Wu, Gang, Partridge, Janet F., Roberts, Charles W. M.

“…Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in nearly 25% of cancers. To gain insight into the mechanisms by which…”
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The SWI/SNF complex - chromatin and cancer by Roberts, Charles W. M, Orkin, Stuart H

“…Key Points The SWI/SNF complex is an evolutionarily conserved multi-subunit chromatin-remodelling complex, which uses the energy of ATP hydrolysis to mobilize…”
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Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer by Genovese, Giannicola, Carugo, Alessandro, Tepper, James, Robinson, Frederick Scott, Li, Liren, Svelto, Maria, Nezi, Luigi, Corti, Denise, Minelli, Rosalba, Pettazzoni, Piergiorgio, Gutschner, Tony, Wu, Chia-Chin, Seth, Sahil, Akdemir, Kadir Caner, Leo, Elisabetta, Amin, Samirkumar, Molin, Marco Dal, Ying, Haoqiang, Kwong, Lawrence N., Colla, Simona, Takahashi, Koichi, Ghosh, Papia, Giuliani, Virginia, Muller, Florian, Dey, Prasenjit, Jiang, Shan, Garvey, Jill, Liu, Chang-Gong, Zhang, Jianhua, Heffernan, Timothy P., Toniatti, Carlo, Fleming, Jason B., Goggins, Michael G., Wood, Laura D., Sgambato, Alessandro, Agaimy, Abbas, Maitra, Anirban, Roberts, Charles W. M., Wang, Huamin, Viale, Andrea, DePinho, Ronald A., Draetta, Giulio F., Chin, Lynda

“…Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly…”
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Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies by Frühwald, Michael C, Biegel, Jaclyn A, Bourdeaut, Franck, Roberts, Charles W M, Chi, Susan N

“…Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant CNS tumor of children below 6 months of age. The majority of AT/RTs demonstrate genomic…”
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