Search Results - "Charles, G"

Pediatric acute lymphoblastic leukemia by Inaba, Hiroto, Mullighan, Charles G

“…The last decade has witnessed great advances in our understanding of the genetic and biological basis of childhood acute lymphoblastic leukemia (ALL), the…”
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Acute Lymphoblastic Leukemia in Children by Hunger, Stephen P, Mullighan, Charles G

“…The most common cancer in childhood is now curable in 90% of patients. Current efforts are focused on devising molecular-based therapy for the subsets of acute…”
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Genetic Basis of Acute Lymphoblastic Leukemia by Iacobucci, Ilaria, Mullighan, Charles G

“…Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and despite cure rates exceeding 90% in children, it remains an important cause of…”
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Structural Classification of Toxic Amyloid Oligomers by Glabe, Charles G.

“…Amyloid oligomers are believed to play important causal roles in many types of amyloid-related degenerative diseases. Many different laboratories have reported…”
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Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy by Topalian, Suzanne L., Drake, Charles G., Pardoll, Drew M.

“…The immune system recognizes and is poised to eliminate cancer but is held in check by inhibitory receptors and ligands. These immune checkpoint pathways,…”
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Chronology of Lake Bonneville, 30,000 to 10,000 yr B.P by Oviatt, Charles G.

“…368 radiocarbon ages between 30 and 10 cal ka for samples collected from outcrops and shorelines from the Lake Bonneville basin have been compiled for this…”
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Molecular genetics of B-precursor acute lymphoblastic leukemia by Mullighan, Charles G

“…B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and the leading cause of cancer-related death in children and young adults…”
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Prostate cancer as a model for tumour immunotherapy by Drake, Charles G

“…Key Points Recent US Food and Drug Administration (FDA) approval of the prostate cancer vaccine known as sipuleucel-T (Provenge; Dendreon Inc) marks the first…”
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Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy by Sharabi, Andrew B, Dr, Lim, Michael, MD, DeWeese, Theodore L, Prof, Drake, Charles G, Prof

“…Summary Checkpoint blockade immunotherapy has received mainstream attention as a result of striking and durable clinical responses in some patients with…”
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Role of IL-6 in asthma and other inflammatory pulmonary diseases by Rincon, Mercedes, Irvin, Charles G

“…The incidence and severity of chronic lung diseases is growing and affects between 100 and 150 million people worldwide and is associated with a significant…”
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Kidney Cancer: An Overview of Current Therapeutic Approaches by Chowdhury, Nivedita, Drake, Charles G

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Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine by Hunger, Stephen P., Mullighan, Charles G.

“…Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a leading cause of cancer death in the young. In the last decade, microarray…”
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Medical Education Reimagined: A Call to Action by Prober, Charles G., Khan, Salman

“…The authors propose a new model for medical education based on the “flipped classroom” design. In this model, students would access brief (~10 minute) online…”
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Acute lymphoblastic leukaemia by Inaba, Hiroto, Dr, Greaves, Mel, Prof, Mullighan, Charles G, MD

“…Summary Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks between 2 and 5 years of age. Causation is multifactorial and…”
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International Humanitarian Law in the Israeli-Gaza Conflict by Kels, Charles G

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Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation by Mahat, Dig B., Salamanca, H. Hans, Duarte, Fabiana M., Danko, Charles G., Lis, John T.

“…The heat shock response (HSR) is critical for survival of all organisms. However, its scope, extent, and the molecular mechanism of regulation are poorly…”
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Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity by Topalian, Suzanne L, Drake, Charles G, Pardoll, Drew M

“…Highlights ► PD-1/B7-H1 are pivotal in maintaining an immunosuppressive tumor microenvironment. ► PD-1 and CTLA-4 play distinct roles in regulating immunity. ►…”
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Ipilimumab: An Anti-CTLA-4 Antibody for Metastatic Melanoma by LIPSON, Evan J, DRAKE, Charles G

“…Ipilimumab (MDX-010, Yervoy; Bristol-Myers Squibb), a fully human monoclonal antibody against CTL antigen 4 (CTLA-4), was recently approved by the U.S. Food…”
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Censorship of the Patient-Physician Relationship by Kels, Charles G.

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Advances in germline predisposition to acute leukaemias and myeloid neoplasms by Klco, Jeffery M., Mullighan, Charles G.

“…Although much work has focused on the elucidation of somatic alterations that drive the development of acute leukaemias and other haematopoietic diseases, it…”
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