Search Results - "Chargelegue, D"

A longitudinal study of the IgG antibody response to HIV‐1 pl7 gag protein in HIV‐1+ patients with haemophilia: titre and avidity by CHARGELEGUE, D., O'TOOLE, C. M., COLVIN, B. T.

“…SUMMARY The IgG response to HIV‐1 pl7 gag protein was studied for up to 6 years in 12 HIV‐1‐infected patients with haemophilia, who had seroconverted between…”
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A murine monoclonal antibody produced in transgenic plants with plant-specific glycans is not immunogenic in mice by CHARGELEGUE, Daniel, VINE, Nicholas D, VAN DOLLEWEERD, Craig J, DRAKE, Pascal M. W, MA, Julian K-C

“…Previous studies have shown that the production of recombinant antibodies in plants is highly efficient and presents numerous therapeutic applications. It is,…”
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Rhizosecretion of a monoclonal antibody protein complex from transgenic tobacco roots by Drake, Pascal M W, Chargelegue, Daniel M, Vine, Nicholas D, van Dolleweerd, Craig J, Obregon, Patricia, Ma, Julian K C

“…The secretion of a functional, full-length monoclonal antibody complex from transgenic Nicotiana tabacum roots has been demonstrated. Initially, seeds were…”
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Identification of an immunodominant neutralizing and protective epitope from measles virus fusion protein by using human sera from acute infection by Atabani, S F, Obeid, O E, Chargelegue, D, Aaby, P, Whittle, H, Steward, M W

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The affinity of IgG antibodies to gag p24 and p17 in HIV‐1‐infected patients correlates with disease progression by CHARGELEGUE, D., STANLEY, C. M., O'TOOLE, C. M., COLVIN, B. T., STEWARD, M. W.

“…SUMMARY The affinity of anti‐gag antibody was studied for up to 9 years (1984–1993) in sera from 15 HIV‐1+ patients with haemophilia. On the basis of their…”
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The Absence or Loss of Antibodies of High Affinity to Human Immunodeficiency Virus (HIV) Is Associated with Disease Progression in HIV-1-Infected Patients by Chargelegue, Daniel, Stanley, Carolynne M., O'Toole, Carol M., Colvin, Brian T., Steward, Michael W.

“…Our data and that of Brostroem et al. indicate early that HIV-specific antibodies of high affinity are maintained only in long-term asymptomatic patients (…”
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A longitudinal study of the IgG antibody response to HIV-1 p17 gag protein in HIV-1+ patients with haemophilia : titre and avidity by CHARGELEGUE, D, O'TOOLE, C. M, COLVIN, B. T

“…The IgG response to HIV-1 p17 gag protein was studied for up to 6 years in 12 HIV-1-infected patients with haemophilia, who had seroconverted between 1982 and…”
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Peptide mimics of a conformationally constrained protective epitopes of respiratory syncytial virus fusion protein by Chargelegue, D, Obeid, O.E, Shaw, D.M, Denbury, A.N, Hobby, P, Hsu, S.C, Steward, M.W

“…Aims: To identify peptides that mimic (mimotopes) conformational and protective epitopes of RSV fusion protein and to assess their efficacy as immunogens and…”
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Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans by Ma, Julian K.-C, Hikmat, Ban Y, Wycoff, Keith, Vine, Nicholas D, Chargelegue, Daniel, Yu, Lloyd, Hein, Mich B, Lehner, Thomas

“…A functional comparison was made between a monoclonal secretory antibody generated in transgenic plants and its parent murine IgG antibody.The affinity…”
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Highly Immunogenic and Protective Recombinant Vaccine Candidate Expressed in Transgenic Plants by CHARGELEGUE, Daniel, DRAKE, Pascal M. W, OBREGON, Patricia, PRADA, Alessandra, FAIRWEATHER, Neil, MA, Julian K-C

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HIV-1 p24-immunoglobulin fusion molecule: a new strategy for plant-based protein production by Obregon, Patricia, Chargelegue, Daniel, Drake, Pascal M W, Prada, Alessandra, Nuttall, James, Frigerio, Lorenzo, Ma, Julian K-C

“…We describe the engineering of a human immunodeficiency virus-1 (HIV-1) p24-immunoglobulin A (IgA) antigen-antibody fusion molecule for therapeutic purposes…”
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Antibody processing and engineering in plants, and new strategies for vaccine production by Ma, Julian K-C., Drake, Pascal M.W., Chargelegue, Daniel, Obregon, Patricia, Prada, Alessandra

“…The use of transgenic plants for the production of recombinant proteins is not a universal solution for all proteins. The choice of this expression system…”
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Peptide-mimics identified from a combinatorial library induce respiratory syncytial virus (RSV) specific neutralising antibody responses and reduce viral load in vivo by Chargelegue, D

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Transgenic plants for vaccine production: expectations and limitations by Chargelegue, Daniel, Obregon, Patricia, Drake, Pascal M.W

“…The expression of antigens in vegetables and fruits has opened up a new avenue for the development of oral vaccines. In a recent report, an oral…”
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Peptide Mapping of a Novel Discontinuous Epitope of the Major Surface Adhesin from Streptococcus mutans by van Dolleweerd, Craig J, Kelly, Charles G, Chargelegue, Daniel, Ma, Julian K-C

“…Guy's 13 is a mouse monoclonal antibody that specifically recognizes the major cell-surface adhesion protein SA I/II of Streptococcus mutans , one of the major…”
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Characterization of the Conformational Epitope of Guy's 13, a Monoclonal Antibody That Prevents Streptococcus mutans Colonization in Humans by VAN DOLLEWEERD, Craig J, CHARGELEGUE, Daniel, MA, Julian K.-C

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Synergistic effect of immunization with a peptide cocktail inducing antibody, helper and cytotoxic T-cell responses on protection against respiratory syncytial virus by Hsu, SC, Chargelegue, D, Obeid, OE, Steward, MW

“…SC Hsu, D Chargelegue, OE Obeid and MW Steward Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street,…”
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Transgenic plants expressing antibodies: a model for phytoremediation by Drake, Pascal M. W., Chargelegue, Daniel, Vine, Nicholas D., Dolleweerd, Craig J., Obregon, Patricia, Ma, Julian K.‐C.

“…ABSTRACT The feasibility of using antibody expressing transgenic plants either to neutralize bioactive molecules in the rhizosphere, or to accumulate and…”
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A Peptide Mimic of a Protective Epitope of Respiratory Syncytial Virus Selected from a Combinatorial Library Induces Virus-Neutralizing Antibodies and Reduces Viral Load In Vivo by Chargelegue, D, Obeid, O E, Hsu, S C, Shaw, M D, Denbury, A N, Taylor, G, Steward, M W

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Reduction of respiratory syncytial viral load in mice after intranasal immunization with a single T-cell epitope linked to a fusion peptide by Hsu, S.C., Chargelegue, D., Steward, M.W.

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