Search Results - "Charest, Mark G"

Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics by Charest, Mark G, Lerner, Christian D, Brubaker, Jason D, Siegel, Dionicio R, Myers, Andrew G

“…Complex antibiotics based on natural products are almost invariably prepared by semisynthesis, or chemical transformation of the isolated natural products…”
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Synthesis of (−)-Tetracycline by Charest, Mark G, Siegel, Dionicio R, Myers, Andrew G

“…We describe a convergent, enantioselective synthesis of (−)-tetracycline (1) from benzoic acid (17 steps, 1.1% yield). Benzoic acid was transformed into the AB…”
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Synthesis of a Broad Array of Highly Functionalized, Enantiomerically Pure Cyclohexanecarboxylic Acid Derivatives by Microbial Dihydroxylation of Benzoic Acid and Subsequent Oxidative and Rearrangement Reactions by Myers, Andrew G, Siegel, Dionicio R, Buzard, Daniel J, Charest, Mark G

“…We have found that the 1,2-dihydroxylation of benzoic acid with Alcaligenes eutrophus strain B9, first reported in 1971 by Reiner and Hegeman, is readily…”
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