Search Results - "Charest, Gabriel"

Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach for Primary Brain Tumors by Déry, Laurence, Charest, Gabriel, Guérin, Brigitte, Akbari, Mohsen, Fortin, David

“…Chemoattraction is a normal and essential process, but it can also be involved in tumorigenesis. This phenomenon plays a key role in glioblastoma (GBM). The…”
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Concomitant Chemoradiation Therapy with Gold Nanoparticles and Platinum Drugs Co-Encapsulated in Liposomes by Charest, Gabriel, Tippayamontri, Thititip, Shi, Minghan, Wehbe, Mohamed, Anantha, Malathi, Bally, Marcel, Sanche, Léon

“…A liposomal formulation of gold nanoparticles (GNPs) and carboplatin, named LipoGold, was produced with the staggered herringbone microfluidic method. The…”
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Liposomal formulations of carboplatin injected by convection-enhanced delivery increases the median survival time of F98 glioma bearing rats by Shi, Minghan, Anantha, Malathi, Wehbe, Mohamed, Bally, Marcel B, Fortin, David, Roy, Laurent-Olivier, Charest, Gabriel, Richer, Maxime, Paquette, Benoit, Sanche, Léon

“…Effectiveness of chemotherapy for treating glioblastoma (GBM) brain tumors is hampered by the blood-brain barrier which limits the entry into the brain of most…”
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A Drug-Eluting Injectable NanoGel for Localized Delivery of Anticancer Drugs to Solid Tumors by Godau, Brent, Samimi, Sadaf, Seyfoori, Amir, Samiei, Ehsan, Khani, Tahereh, Naserzadeh, Parvaneh, Najafabadi, Alireza Hassani, Lesha, Emal, Majidzadeh-A, Keivan, Ashtari, Behnaz, Charest, Gabriel, Morin, Christophe, Fortin, David, Akbari, Mohsen

“…Systemically administered chemotherapy reduces the efficiency of the anticancer agent at the target tumor tissue and results in distributed drug to non-target…”
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Glioblastoma Treatment: Bypassing the Toxicity of Platinum Compounds by Using Liposomal Formulation and Increasing Treatment Efficiency With Concomitant Radiotherapy by Charest, Gabriel, Ph.D, Sanche, Léon, Ph.D, Fortin, David, M.D, Mathieu, David, M.D, Paquette, Benoit, Ph.D

“…Purpose Treatments of glioblastoma with cisplatin or oxaliplatin only marginally improve the overall survival of patients and cause important side effects. To…”
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Essential Role of the NH2-terminal WD/EPF Motif in the Phosphorylation-activated Protective Function of Mammalian Hsp27 by Thériault, Jimmy R., Lambert, Herman, Chávez-Zobel, Aura T., Charest, Gabriel, Lavigne, Pierre, Landry, Jacques

“…Hsp27 is expressed at high levels after mild heat shock and contributes to making cells extremely resistant to subsequent treatments. The activity of the…”
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EXTH-29. EVALUATION OF THE ANTITUMOR EFFECT OF A CHEMOTHERAPY-LOADED DEVICE FOR THE TREATMENT OF PRIMARY BRAIN TUMORS by Déry, Laurence, Charest, Gabriel, Guérin, Brigitte, Akbari, Mohsen, Fortin, David

“…Abstract Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in adults. Tumor recurrence is therefore inevitable, and median survival is…”
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EXTH-25. OPTIMIZATION OF NEW CHEMOTHERAPEUTIC AGENTS BY INTRA-ARTERIAL INFUSION IN GLIOBLASTOMAS by Latulippe, Juliette, Roy, Laurent-Olivier, Charest, Gabriel, Gobeil, Fernand Jr, Fortin, David

“…Abstract Being the most aggressive malignant primary brain tumor, glioblastoma (GBM) is a difficult disease to treat. The first line treatment is well…”
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Optimization of the route of platinum drugs administration to optimize the concomitant treatment with radiotherapy for glioblastoma implanted in the Fischer rat brain by Charest, Gabriel, Sanche, Léon, Fortin, David, Mathieu, David, Paquette, Benoit

“…Treatment of glioblastoma with platinum compounds modestly improves progression-free survival and may cause toxic effects which prevent use at higher dose that…”
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Cyclooxygenase-2 inhibitor prevents radiation-enhanced infiltration of F98 glioma cells in brain of Fischer rat by Desmarais, Guillaume, Charest, Gabriel, Fortin, David, Bujold, Rachel, Mathieu, David, Paquette, Benoit

“…Purpose: Radiation induces a neuro-inflammation that is characterized by the expression of genes known to increase the invasion of cancer cells. In Fischer…”
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Radiolabeled antibodies to validate blood brain barrier penetration by Charest, Gabriel, Ait-mohand, Samia, Sarrhini, Otman, Rousseau, Jacques, Stanimirovic, Danica, Hutchison, Rob, tin, David, Guerin, Brigitte

“…Objectives: Detecting and treating diseases of the central nervous system is extremely limited by the capacities of imaging agents and drugs to cross the blood…”
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Tumor Cell Invasion Induced by Radiation in Balb/C Mouse is Prevented by the Cox-2 Inhibitor NS-398 by Lemay, Rosalie, Lepage, Martin, Tremblay, Luc, Therriault, Hélène, Charest, Gabriel, Paquette, Benoit

“…Radiation stimulates the expression of inflammatory mediators known to increase cancer cell invasion. Therefore, it is important to determine whether…”
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SCDT-45. ANTIBODY-BASED PET IMAGING OF BRAIN CANCER CELLS INFILTRATION by Charest, Gabriel, Sarrhini, Otman, Fortin, David, Stanimirovic, Danica, Gabathuler, Reinhard, Guérin, Brigitte

“…Infiltrated glioblastoma (GBM) cells into the brain parenchyma cause recurrences after tumor resection and there is presently no efficient non-invasive method…”
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Infiltration of F98 glioma cells in Fischer rat brain is temporary stimulated by radiation by Desmarais, Guillaume, Charest, Gabriel, Therriault, Hélène, Shi, Minghan, Fortin, David, Bujold, Rachel, Mathieu, David, Paquette, Benoit

“…Purpose: Irradiation of brain stimulates the expression of inflammatory mediators, some of which can modify the ability of cancer cells to infiltrate the…”
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Concomitant treatment of F98 glioma cells with new liposomal platinum compounds and ionizing radiation by Charest, Gabriel, Paquette, Benoit, Fortin, David, Mathieu, David, Sanche, Léon

“…Despite significant advances, the radiotherapy and chemotherapy protocols marginally improve the overall survival of patients with glioblastoma. Lipoplatin TM…”
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Gamma Knife irradiation method based on dosimetric controls to target small areas in rat brains by Constanzo, Julie, Paquette, Benoit, Charest, Gabriel, Masson‐Côté, Laurence, Guillot, Mathieu

“…Purpose: Targeted and whole‐brain irradiation in humans can result in significant side effects causing decreased patient quality of life. To adequately…”
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Simple and versatile restraints for the accurate modeling of [alpha]-helical coiled-coil structures of multiple strandedness, orientation and composition by Charest, Gabriel, Lavigne, Pierre

“…We present a minimalist approach for the modeling of the three-dimensional structure of multistranded [alpha]-helical coiled coils. The approach is based on…”
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Évaluation des capacités radiosensibilisantes de composés platinés das le traitement des glioblastomes by Charest, Gabriel

“…Glioblastoma multiforme (GBM) is the most aggressive primary tumor of the brain, taking the lives of patients 12 to 14 months from diagnosis and standard…”
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Polymer gel in rat skull to assess the accuracy of a new rat stereotactic device for use with the Gamma Knife by Charest, Gabriel, Mathieu, David, Lepage, Martin, Fortin, David, Paquette, Benoit, Sanche, Léon

“…Purpose Accurate targeting is crucial for the irradiation of a small-volume animal brain. We propose an original method, based on a polymer gel, to determine…”
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Simple and versatile restraints for the accurate modeling of α-helical coiled-coil structures of multiple strandedness, orientation and composition by Charest, Gabriel, Lavigne, Pierre

“…We present a minimalist approach for the modeling of the three‐dimensional structure of multistranded α‐helical coiled coils. The approach is based on…”
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