Search Results - "Chard Dunmall, Louisa S."

Natural products targeting glycolysis in cancer by Zhao, Yuanyuan, Chard Dunmall, Louisa S, Cheng, Zhenguo, Wang, Yaohe, Si, Lingling

“…Many energy metabolism pathways exist in cancer, including glycolysis, amino acid metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells…”
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Characterization of the Intra-tumoral B Cell Immunoglobulin Repertoire Is of Prognostic Value for Esophageal Squamous Cell Carcinoma by Wang, Zhizhong, Cheng, Zhenguo, Lu, Shuangshuang, Chard Dunmall, Louisa S., Wang, Jun, Guo, Yongjun, Wang, Yaohe

“…Esophageal Squamous Cell carcinomas (ESCC) is a highly heterogeneous malignancy that is among the leading cause of cancer-related death worldwide. B cells play…”
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Ferroptosis-Related Genes Are Potential Therapeutic Targets and the Model of These Genes Influences Overall Survival of NSCLC Patients by Zhang, Na, Wu, Yangyang, Wu, Yifan, Wang, Lihong, Chen, Jingfei, Wang, Xiaosa, Chard Dunmall, Louisa S, Cheng, Zhenguo, Wang, Yaohe

“…Background: Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSCC) are two of the most common subtypes of non-small cell lung cancer (NSCLC), with…”
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An effective therapeutic regime for treatment of glioma using oncolytic vaccinia virus expressing IL-21 in combination with immune checkpoint inhibition by Sun, Yijie, Zhang, Zhe, Zhang, Chenglin, Zhang, Na, Wang, Pengju, Chu, Yongchao, Chard Dunmall, Louisa S., Lemoine, Nicholas R., Wang, Yaohe

“…Glioblastoma (GBM) is the most common primary malignant tumor in the brain, accounting for 51.4% of all primary brain tumors. GBM has a highly…”
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A systemically deliverable Vaccinia virus with increased capacity for intertumoral and intratumoral spread effectively treats pancreatic cancer by Marelli, Giulia, Chard Dunmall, Louisa S, Yuan, Ming, Di Gioia, Carmela, Miao, Jinxin, Cheng, Zhenguo, Zhang, Zhongxian, Liu, Peng, Ahmed, Jahangir, Gangeswaran, Rathi, Lemoine, Nicholas, Wang, Yaohe

“…BackgroundPancreatic cancer remains one of the most lethal cancers and is refractory to immunotherapeutic interventions. Oncolytic viruses are a promising new…”
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A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer by Wang, Na, Wang, Jiwei, Zhang, Zhe, Cao, Hua, Yan, Wenli, Chu, Yongchao, Chard Dunmall, Louisa S., Wang, Yaohe

“…Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world, and there remains an urgent need to develop long-lasting…”
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Redirecting anti-Vaccinia virus T cell immunity for cancer treatment by AAV-mediated delivery of the VV B8R gene by Cao, Dujuan, Song, Qianqian, Li, Junqi, Chard Dunmall, Louisa S., Jiang, Yuanyuan, Qin, Bin, Wang, Jianyao, Guo, Haoran, Cheng, Zhenguo, Wang, Zhimin, Lemoine, Nicholas R., Lu, Shuangshuang, Wang, Yaohe

“…Immunotherapies, such as immune checkpoint inhibitors (ICIs) and chimeric antigen receptor-T (CAR-T) cells, are only efficient in a small proportion of tumor…”
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Remodeling the tumor microenvironment by oncolytic viruses: beyond oncolysis of tumor cells for cancer treatment by Wang, Lihong, Chard Dunmall, Louisa S, Cheng, Zhenguo, Wang, Yaohe

“…Tumor cells manipulate the local environment in which they grow, creating a tumor microenvironment (TME) that promotes tumor survival and metastasis. The TME…”
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Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus by Ferguson, Mark S., Chard Dunmall, Louisa S., Gangeswaran, Rathi, Marelli, Giulia, Tysome, James R., Burns, Emily, Whitehead, Maria A., Aksoy, Ezra, Alusi, Ghassan, Hiley, Crispin, Ahmed, Jay, Vanhaesebroeck, Bart, Lemoine, Nicholas R., Wang, Yaohe

“…Tumor-targeting oncolytic viruses such as vaccinia virus (VV) are attractive cancer therapeutic agents that act through multiple mechanisms to provoke both…”
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A novel microenvironment regulated system CAR-T (MRS.CAR-T) for immunotherapeutic treatment of esophageal squamous carcinoma by Wang, Lihong, Wang, Xiaosa, Wu, Yangyang, Wang, Jingjing, Zhou, Wenping, Wang, Jianyao, Guo, Haoran, Zhang, Na, Zhang, Lufang, Hu, Xuanyu, Zhao, Yuanyuan, Miao, Jinxin, Zhang, Zifang, Chard Dunmall, Louisa S., Zhang, Danhua, Lemoine, Nicholas R., Cheng, Zhenguo, Wang, Yaohe

“…Chimeric antigen receptor T cell immunotherapy has achieved promising therapeutic effects in the treatment of hematological malignancies. However, there are…”
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Syrian hamster as an ideal animal model for evaluation of cancer immunotherapy by Jia, Yangyang, Wang, Yanru, Dunmall, Louisa S Chard, Lemoine, Nicholas R, Wang, Pengju, Wang, Yaohe

“…Cancer immunotherapy (CIT) has emerged as an exciting new pillar of cancer treatment. Although benefits have been achieved in individual patients, the overall…”
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Promising xenograft animal model recapitulating the features of human pancreatic cancer by Miao, Jin-Xin, Wang, Jian-Yao, Li, Hao-Ze, Guo, Hao-Ran, Dunmall, Louisa S Chard, Zhang, Zhong-Xian, Cheng, Zhen-Guo, Gao, Dong-Ling, Dong, Jian-Zeng, Wang, Zhong-De, Wang, Yao-He

“…Multiple sites of metastasis and desmoplastic reactions in the stroma are key features of human pancreatic cancer (PC). There are currently no simple and…”
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The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma by Jiang, Guozhong, Wang, Zhizhong, Cheng, Zhenguo, Wang, Weiwei, Lu, Shuangshuang, Zhang, Zifang, Anene, Chinedu A., Khan, Faraz, Chen, Yue, Bailey, Emma, Xu, Huisha, Dong, Yunshu, Chen, Peinan, Zhang, Zhongxian, Gao, Dongling, Wang, Zhimin, Miao, Jinxin, Xue, Xia, Wang, Pengju, Zhang, Lirong, Gangeswaran, Rathi, Liu, Peng, Chard Dunmall, Louisa S., Li, Junkuo, Guo, Yongjun, Dong, Jianzeng, Lemoine, Nicholas R., Li, Wencai, Wang, Jun, Wang, Yaohe

“…Esophageal squamous cell carcinoma (ESCC) is highly heterogeneous. Our understanding of full molecular and immune landscape of ESCC remains limited, hindering…”
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The capability of heterogeneous γδ T cells in cancer treatment by Yan, Wenyi, Dunmall, Louisa S Chard, Lemoine, Nicholas R, Wang, Yaohe, Wang, Yafeng, Wang, Pengju

“…γδ T cells, a specialized subset of T lymphocytes, have garnered significant attention within the realm of cancer immunotherapy. Operating at the nexus between…”
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MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapy by Baleeiro, Renato B., Bouwens, Christian J., Liu, Peng, Di Gioia, Carmela, Dunmall, Louisa S. Chard, Nagano, Ai, Gangeswaran, Rathistevy, Chelala, Claude, Kocher, Hemant M., Lemoine, Nicholas R., Wang, Yaohe

“…MHC class II expression is a hallmark of professional antigen-presenting cells and key to the induction of CD4+ T helper cells. We found that these molecules…”
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Optimized Anchor-Modified Peptides Targeting Mutated RAS Are Promising Candidates for Immunotherapy by Baleeiro, Renato B., Dunmall, Louisa S. Chard, Liu, Peng, Lu, Shuangshuang, Lone, Yuchun, Lemoine, Nicholas R., Wang, Yaohe

“…RAS mutations occur in approximately 20% of all cancers and given their clonality, key role as driver mutation, association with poor prognosis and…”
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Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancer by Brito Baleeiro, Renato, Liu, Peng, Chard Dunmall, Louisa S, Di Gioia, Carmela, Nagano, Ai, Cutmore, Lauren, Wang, Jun, Chelala, Claude, Nyambura, Lydon Wainaina, Walden, Peter, Lemoine, Nicholas, Wang, Yaohe

“…Triple-negative breast cancer (TNBC) corresponds to approximately 20% of all breast tumors, with a high propensity for metastasis and a poor prognosis. Because…”
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Treatment and Prevention of Lung Cancer Using a Virus-Infected Reprogrammed Somatic Cell-Derived Tumor Cell Vaccination (VIReST) Regime by Zhang, Zhe, Lu, Shuangshuang, Dunmall, Louisa S Chard, Wang, Zhizhong, Cheng, Zhenguo, Zhang, Zhongxian, Yan, Wenli, Chu, Yongchao, Gao, Dongling, Wang, Na, Li, Yang, Wang, Jiwei, Li, Yuenan, Ji, Yupei, Shan, Danyang, Li, Keke, Wang, Panpan, Dong, Yunshu, Dong, Jianzeng, Lemoine, Nick R, Pei, Duanqing, Zhang, Lirong, Wang, Yaohe

“…Lung cancer is one of the most commonly diagnosed cancer and despite therapeutic advances, mortality remains high. The long period of clinical latency…”
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A Tumor-Targeted Replicating Oncolytic Adenovirus Ad-TD-nsIL12 as a Promising Therapeutic Agent for Human Esophageal Squamous Cell Carcinoma by Zhang, Zifang, Zhang, Chunyang, Miao, Jinxin, Wang, Zhizhong, Wang, Zhimin, Cheng, Zhenguo, Wang, Pengju, Dunmall, Louisa S Chard, Lemoine, Nicholas R, Wang, Yaohe

“…Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers in China and existing therapies have been unable to significantly improve…”
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