Search Results - "Charchar, Fadi J."

Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys by Wang, Yutang, Charchar, Fadi J.

“…Men have higher circulating levels of uric acid than women. This sex difference is suspected to be a result of suppressive effects of estradiol on uric acid…”
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Epigenetic Modifications in Essential Hypertension by Wise, Ingrid A, Charchar, Fadi J

“…Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of…”
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The Y chromosome: a blueprint for men's health? by Maan, Akhlaq A, Eales, James, Akbarov, Artur, Rowland, Joshua, Xu, Xiaoguang, Jobling, Mark A, Charchar, Fadi J, Tomaszewski, Maciej

“…The Y chromosome has long been considered a 'genetic wasteland' on a trajectory to completely disappear from the human genome. The perception of its…”
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Gene Expression Profiling Reveals Renin mRNA Overexpression in Human Hypertensive Kidneys and a Role for MicroRNAs by Marques, Francine Z, Campain, Anna E, Tomaszewski, Maciej, Zukowska-Szczechowska, Ewa, Yang, Yee Hwa J, Charchar, Fadi J, Morris, Brian J

“…The kidney has long been invoked in the etiology of essential hypertension. This could involve alterations in expression of specific genes and microRNAs…”
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Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies by Morris, Andrew P., Le, Thu H., Wu, Haojia, Akbarov, Artur, van der Most, Peter J., Hemani, Gibran, Smith, George Davey, Mahajan, Anubha, Gaulton, Kyle J., Nadkarni, Girish N., Valladares-Salgado, Adan, Wacher-Rodarte, Niels, Mychaleckyj, Josyf C., Dueker, Nicole D., Guo, Xiuqing, Hai, Yang, Haessler, Jeffrey, Kamatani, Yoichiro, Stilp, Adrienne M., Zhu, Gu, Cook, James P., Ärnlöv, Johan, Blanton, Susan H., de Borst, Martin H., Bottinger, Erwin P., Buchanan, Thomas A., Cechova, Sylvia, Charchar, Fadi J., Chu, Pei-Lun, Damman, Jeffrey, Eales, James, Gharavi, Ali G., Giedraitis, Vilmantas, Heath, Andrew C., Ipp, Eli, Kiryluk, Krzysztof, Kramer, Holly J., Kubo, Michiaki, Larsson, Anders, Lindgren, Cecilia M., Lu, Yingchang, Madden, Pamela A. F., Montgomery, Grant W., Papanicolaou, George J., Raffel, Leslie J., Sacco, Ralph L., Sanchez, Elena, Stark, Holger, Sundstrom, Johan, Taylor, Kent D., Xiang, Anny H., Zivkovic, Aleksandra, Lind, Lars, Ingelsson, Erik, Martin, Nicholas G., Whitfield, John B., Cai, Jianwen, Laurie, Cathy C., Okada, Yukinori, Matsuda, Koichi, Kooperberg, Charles, Chen, Yii-Der Ida, Rundek, Tatjana, Rich, Stephen S., Loos, Ruth J. F., Parra, Esteban J., Cruz, Miguel, Rotter, Jerome I., Snieder, Harold, Tomaszewski, Maciej, Humphreys, Benjamin D., Franceschini, Nora

“…Chronic kidney disease (CKD) affects ~10% of the global population, with considerable ethnic differences in prevalence and aetiology. We assemble genome-wide…”
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Dietary fatty acids and mortality risk from heart disease in US adults: an analysis based on NHANES by Wang, Yutang, Fang, Yan, Witting, Paul K., Charchar, Fadi J., Sobey, Christopher G., Drummond, Grant R., Golledge, Jonathan

“…We investigated the association of dietary intake of major types of fatty acids with heart disease mortality in a general adult cohort with or without a prior…”
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Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome by Charchar, Fadi J, PhD, Bloomer, Lisa DS, MSc, Barnes, Timothy A, PhD, Cowley, Mark J, PhD, Nelson, Christopher P, PhD, Wang, Yanzhong, PhD, Denniff, Matthew, BSc, Debiec, Radoslaw, MD, Christofidou, Paraskevi, MSc, Nankervis, Scott, PhD, Dominiczak, Anna F, MD, Bani-Mustafa, Ahmed, PhD, Balmforth, Anthony J, MD, Hall, Alistair S, MD, Erdmann, Jeanette, PhD, Cambien, Francois, PhD, Deloukas, Panos, PhD, Hengstenberg, Christian, MD, Packard, Chris, MD, Schunkert, Heribert, MD, Ouwehand, Willem H, MD, Ford, Ian, PhD, Goodall, Alison H, PhD, Jobling, Mark A, PhD, Samani, Nilesh J, MD, Tomaszewski, Maciej, Dr

“…Summary Background A sexual dimorphism exists in the incidence and prevalence of coronary artery disease—men are more commonly affected than are age-matched…”
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A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease by Prestes, Priscilla R, Maier, Michelle C, Woods, Bradley A, Charchar, Fadi J

“…Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompasses many diseased states, including…”
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Acute exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells by Chilton, Warrick L, Marques, Francine Z, West, Jenny, Kannourakis, George, Berzins, Stuart P, O'Brien, Brendan J, Charchar, Fadi J

“…Telomeres are specialized nucleoprotein structures that protect chromosomal ends from degradation. These structures progressively shorten during cellular…”
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Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics by Rowland, Joshua, Akbarov, Artur, Eales, James, Xu, Xiaoguang, Dormer, John P, Guo, Hui, Denniff, Matthew, Jiang, Xiao, Ranjzad, Parisa, Nazgiewicz, Alicja, Prestes, Priscilla Ribeiro, Antczak, Andrzej, Szulinska, Monika, Wise, Ingrid A, Zukowska-Szczechowska, Ewa, Bogdanski, Pawel, Woolf, Adrian S, Samani, Nilesh J, Charchar, Fadi J, Tomaszewski, Maciej

“…Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is known, however, about genetic mechanisms of kidney aging. We…”
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Reduced renal function may explain the higher prevalence of hyperuricemia in older people by Wang, Yutang, Zhang, Wanlin, Qian, Tingting, Sun, Hui, Xu, Qun, Hou, Xujuan, Hu, Wenqi, Zhang, Guang, Drummond, Grant R., Sobey, Christopher G., Charchar, Fadi J., Golledge, Jonathan, Yang, Guang

“…This study aimed to investigate the contribution of renal dysfunction to enhanced hyperuricemia prevalence in older people. A cohort of 13,288 Chinese people…”
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Molecular insights into genome-wide association studies of chronic kidney disease-defining traits by Xu, Xiaoguang, Eales, James M., Akbarov, Artur, Guo, Hui, Becker, Lorenz, Talavera, David, Ashraf, Fehzan, Nawaz, Jabran, Pramanik, Sanjeev, Bowes, John, Jiang, Xiao, Dormer, John, Denniff, Matthew, Antczak, Andrzej, Szulinska, Monika, Wise, Ingrid, Prestes, Priscilla R., Glyda, Maciej, Bogdanski, Pawel, Zukowska-Szczechowska, Ewa, Berzuini, Carlo, Woolf, Adrian S., Samani, Nilesh J., Charchar, Fadi J., Tomaszewski, Maciej

“…Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these…”
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Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets by Xu, Xiaoguang, Khunsriraksakul, Chachrit, Eales, James M., Rubin, Sebastien, Scannali, David, Saluja, Sushant, Talavera, David, Markus, Havell, Wang, Lida, Drzal, Maciej, Maan, Akhlaq, Lay, Abigail C., Prestes, Priscilla R., Regan, Jeniece, Diwadkar, Avantika R., Denniff, Matthew, Rempega, Grzegorz, Ryszawy, Jakub, Król, Robert, Dormer, John P., Szulinska, Monika, Walczak, Marta, Antczak, Andrzej, Matías-García, Pamela R., Waldenberger, Melanie, Woolf, Adrian S., Keavney, Bernard, Zukowska-Szczechowska, Ewa, Wystrychowski, Wojciech, Zywiec, Joanna, Bogdanski, Pawel, Danser, A. H. Jan, Samani, Nilesh J., Guzik, Tomasz J., Morris, Andrew P., Liu, Dajiang J., Charchar, Fadi J., Tomaszewski, Maciej

“…Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated…”
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Longer leukocyte telomeres are associated with ultra-endurance exercise independent of cardiovascular risk factors by Denham, Joshua, Nelson, Christopher P, O'Brien, Brendan J, Nankervis, Scott A, Denniff, Matthew, Harvey, Jack T, Marques, Francine Z, Codd, Veryan, Zukowska-Szczechowska, Ewa, Samani, Nilesh J, Tomaszewski, Maciej, Charchar, Fadi J

“…Telomere length is recognized as a marker of biological age, and shorter mean leukocyte telomere length is associated with increased risk of cardiovascular…”
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SLC2A9 is a high-capacity urate transporter in humans by Caulfield, Mark J, Munroe, Patricia B, O'Neill, Deb, Witkowska, Kate, Charchar, Fadi J, Doblado, Manuel, Evans, Sarah, Eyheramendy, Susana, Onipinla, Abiodun, Howard, Philip, Shaw-Hawkins, Sue, Dobson, Richard J, Wallace, Chris, Newhouse, Stephen J, Brown, Morris, Connell, John M, Dominiczak, Anna, Farrall, Martin, Lathrop, G Mark, Samani, Nilesh J, Kumari, Meena, Marmot, Michael, Brunner, Eric, Chambers, John, Elliott, Paul, Kooner, Jaspal, Laan, Maris, Org, Elin, Veldre, Gudrun, Viigimaa, Margus, Cappuccio, Francesco P, Ji, Chen, Iacone, Roberto, Strazzullo, Pasquale, Moley, Kelle H, Cheeseman, Chris

“…Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome,…”
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A Novel Interaction Between Sympathetic Overactivity and Aberrant Regulation of Renin by miR-181a in BPH/2J Genetically Hypertensive Mice by JACKSON, Kristy L, MARQUES, Francine Z, WATSON, Anna M. D, PALMA-RIGO, Kesia, NGUYEN-HUU, Thu-Phuc, MORRIS, Brian J, CHARCHAR, Fadi J, DAVERN, Pamela J, HEAD, Geoffrey A

“…Genetically hypertensive mice (BPH/2J) are hypertensive because of an exaggerated contribution of the sympathetic nervous system to blood pressure. We…”
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Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting by Nakai, Michael E., Denham, Joshua, Prestes, Priscilla R., Eikelis, Nina, Lambert, Elisabeth A., Straznicky, Nora E., Schlaich, Markus P., Esler, Murray D., O’Brien, Brendan J., Charchar, Fadi J., Lambert, Gavin W., Marques, Francine Z.

“…Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors,…”
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Postprandial Plasma Glucose between 4 and 7.9 h May Be a Potential Diagnostic Marker for Diabetes by Wang, Yutang, Fang, Yan, Aberson, Christopher L, Charchar, Fadi J, Ceriello, Antonio

“…Postprandial glucose levels between 4 and 7.9 h (PPG ) correlate with mortality from various diseases, including hypertension, diabetes, cardiovascular…”
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Wake up and enjoy the coffee without worrying about your blood pressure by Charchar, Fadi J

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Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice by Jackson, Kristy L, Gueguen, Cindy, Lim, Kyungjoon, Eikelis, Nina, Stevenson, Emily R, Charchar, Fadi J, Lambert, Gavin W, Burke, Sandra L, Paterson, Madeleine R, Marques, Francine Z, Head, Geoffrey A

“…BPH/2J mice are a genetic model of hypertension with overactivity of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS). BPH/2J display…”
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