Search Results - "Charbonnier, Sebastian"

The emerging contribution of sequence context to the specificity of protein interactions mediated by PDZ domains by Luck, Katja, Charbonnier, Sebastian, Travé, Gilles

“…The canonical binding mode of PDZ domains to target motifs involves a small interface, unlikely to fully account for PDZ-target interaction specificities…”
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Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins by Zanier, Katia, Charbonnier, Sebastian, Sidi, Abdellahi Ould M'hamed Ould, McEwen, Alastair G., Ferrario, Maria Giovanna, Poussin-Courmontagne, Pierre, Cura, Vincent, Brimer, Nicole, Babah, Khaled Ould, Ansari, Tina, Muller, Isabelle, Stote, Roland H., Cavarelli, Jean, Pol, Scott Vande, Travé, Gilles

“…E6 viral oncoproteins are key players in epithelial tumors induced by papillomaviruses in vertebrates, including cervical cancer in humans. E6 proteins target…”
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Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain by Bernard, Xavier, Robinson, Philip, Nominé, Yves, Masson, Murielle, Charbonnier, Sebastian, Ramirez-Ramos, Juan Ramon, Deryckere, Francois, Travé, Gilles, Orfanoudakis, Georges

“…The E6 oncoprotein produced by high-risk mucosal HPV stimulates ubiquitinylation and proteasome-dependent degradation of the tumour suppressor p53 via…”
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Structural and Functional Analysis of E6 Oncoprotein: Insights in the Molecular Pathways of Human Papillomavirus-Mediated Pathogenesis by Nominé, Yves, Masson, Murielle, Charbonnier, Sebastian, Zanier, Katia, Ristriani, Tutik, Deryckère, François, Sibler, Annie-Paule, Desplancq, Dominique, Atkinson, Robert Andrew, Weiss, Etienne, Orfanoudakis, Georges, Kieffer, Bruno, Travé, Gilles

“…Oncoprotein E6 is essential for oncogenesis induced by human papillomaviruses (HPVs). The solution structure of HPV16-E6 C-terminal domain reveals a zinc…”
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The social network of a cell: Recent advances in interactome mapping by Charbonnier, Sebastian, Gallego, Oriol, Gavin, Anne-Claude

“…Proteins very rarely act in isolation. Biomolecular interactions are central to all biological functions. In human, for example, interference with biomolecular…”
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Formation of well-defined soluble aggregates upon fusion to MBP is a generic property of E6 proteins from various human papillomavirus species by Zanier, Katia, Nominé, Yves, Charbonnier, Sebastian, Ruhlmann, Christine, Schultz, Patrick, Schweizer, Johannes, Travé, Gilles

“…Protein aggregation is a main barrier hindering structural and functional studies of a number of interesting biological targets. The E6 oncoprotein of Human…”
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Domain Substructure of HPV E6 Oncoprotein:  Biophysical Characterization of the E6 C-Terminal DNA-Binding Domain by Nominé, Yves, Charbonnier, Sebastian, Ristriani, Tutik, Stier, Gunter, Masson, Murielle, Cavusoglu, Nukhet, Van Dorsselaer, Alain, Weiss, Étienne, Kieffer, Bruno, Travé, Gilles

“…E6 is a viral oncoprotein implicated in cervical cancers, produced by high-risk human papillomaviruses (HPVs). Structural data concerning this protein are…”
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Binding of human papillomavirus 16 E6 to p53 and E6AP is impaired by monoclonal antibodies directed against the second zinc-binding domain of E6 by Lagrange, Magali, Charbonnier, Sebastian, Orfanoudakis, Georges, Robinson, Philip, Zanier, Katia, Masson, Murielle, Lutz, Yves, Trave, Gilles, Weiss, Etienne, Deryckere, Francois

“…1 UMR7100, Ecole Supérieure de Biotechnologie de Strasbourg, Pole API, boulevard Sébastien Brant, 67412 Illkirch Cedex, France 2 IGBMC, CNRS/INSERM/ULP, 1 rue…”
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Quantifying domain-ligand affinities and specificities by high-throughput holdup assay by Vincentelli, Renaud, Luck, Katja, Poirson, Juline, Polanowska, Jolanta, Abdat, Julie, Blémont, Marilyne, Turchetto, Jeremy, Iv, François, Ricquier, Kevin, Straub, Marie-Laure, Forster, Anne, Cassonnet, Patricia, Borg, Jean-Paul, Jacob, Yves, Masson, Murielle, Nominé, Yves, Reboul, Jérôme, Wolff, Nicolas, Charbonnier, Sebastian, Travé, Gilles

“…This paper reports an approach to measure equilibrium binding affinities for interacting proteins in high throughput, allowing the rapid and quantitative…”
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The Structural and Dynamic Response of MAGI-1 PDZ1 with Noncanonical Domain Boundaries to the Binding of Human Papillomavirus E6 by Charbonnier, Sebastian, Nominé, Yves, Ramírez, Juan, Luck, Katja, Chapelle, Anne, Stote, Roland H., Travé, Gilles, Kieffer, Bruno, Atkinson, R. Andrew

“…PDZ domains are protein interaction domains that are found in cytoplasmic proteins involved in signaling pathways and subcellular transport. Their roles in the…”
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Disorder-To-Order Transition of MAGI‑1 PDZ1 C‑Terminal Extension upon Peptide Binding: Thermodynamic and Dynamic Insights by Ramírez, Juan, Recht, Raphaël, Charbonnier, Sebastian, Ennifar, Eric, Atkinson, R. Andrew, Travé, Gilles, Nominé, Yves, Kieffer, Bruno

“…PDZ domains are highly abundant protein–protein interaction modules commonly found in multidomain scaffold proteins. The PDZ1 domain of MAGI-1, a protein…”
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Surface plasmon resonance analysis of the binding of high-risk mucosal HPV E6 oncoproteins to the PDZ1 domain of the tight junction protein MAGI-1 by Fournane, Sadek, Charbonnier, Sebastian, Chapelle, Anne, Kieffer, Bruno, Orfanoudakis, Georges, Travé, Gilles, Masson, Murielle, Nominé, Yves

“…The E6 oncoproteins from high‐risk mucosal human papillomavirus (HPV) induce cervical cancer via two major activities, the binding and the degradation of the…”
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Chemical Library Screening Using a SPR-Based Inhibition in Solution Assay: Simulations and Experimental Validation by Choulier, Laurence, Nominé, Yves, Zeder-Lutz, Gabrielle, Charbonnier, Sebastian, Didier, Bruno, Jung, Marie-Louise, Altschuh, Danièle

“…We have developed a surface plasmon resonance (SPR)-based inhibition in solution assay (ISA) to search for inhibitors of the medium affinity (K D = 0.8 μM)…”
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Quantifying domain-ligand affinities and specificities by high-throughput holdup assay by Vincentelli, Renaud, Luck, Katja, Poirson, Juline, Polanowska, Jolanta, Abdat, Julie, Blémont, Marilyne, Turchetto, Jeremy, Iv, François, Ricquier, Kevin, Straub, Marie-Laure, Forster, Anne, Cassonnet, Patricia, Borg, Jean-Paul, Jacob, Yves, Masson, Murielle, Nominé, Yves, Reboul, Jérome, Wolff, Nicolas, Charbonnier, Sebastian, Travé, Gilles

“…Many protein interactions are mediated by small linear motifs interacting specifically with defined families of globular domains. Quantifying the specificity…”
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Prevalence of intrinsic disorder in the hepatitis C virus ARFP/Core+1/S protein by Boumlic, Anissa, Nominé, Yves, Charbonnier, Sebastian, Dalagiorgou, Georgia, Vassilaki, Niki, Kieffer, Bruno, Travé, Gilles, Mavromara, Penelope, Orfanoudakis, Georges

“…The hepatitis C virus (HCV) Core+1/S polypeptide, also known as alternative reading frame protein (ARFP)/S, is an ARFP expressed from the Core coding region of…”
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Capturing protein–protein complexes at equilibrium: The holdup comparative chromatographic retention assay by Charbonnier, Sebastian, Zanier, Katia, Masson, Murielle, Travé, Gilles

“…The popular pulldown chromatographic assay detects complexes mediated by fusion proteins retained on affinity resin. The main limitation of this method is that…”
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Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins by Zanier, Katia, Charbonnier, Sebastian, Sidi, Abdellahi Ould M'Hamed Ould, Mcewen, Alastair, Ferrario, Maria Giovanna, Poussin-Courmontagne, Pierre, Cura, Vincent, Brimer, Nicole, Babah, Khaled Ould, Ansari, Tina, Muller, Isabelle, Stote, Roland, Cavarelli, Jean, Vande Pol, Scott, Travé, Gilles

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A new NMR technique to probe protein-ligand interaction by Viéville, J M P, Charbonnier, S, Eberling, P, Starck, J-P, Delsuc, M-A

“…Non covalent grafting of proteins on affinity phases is a very common approach for isolation, purification and re-concentration of tagged proteins. Many…”
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Kinetic Analysis of the Interactions of Human Papillomavirus E6 Oncoproteins with the Ubiquitin Ligase E6AP Using Surface Plasmon Resonance by Zanier, Katia, Charbonnier, Sebastian, Baltzinger, Mireille, Nominé, Yves, Altschuh, Danièle, Travé, Gilles

“…Cervical cancers evolve from lesions generated by genital human papillomaviruses (HPV). “Low-risk” genital HPVs cause benign proliferations whereas “high-risk”…”
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Defining the minimal interacting regions of the tight junction protein MAGI-1 and HPV16 E6 oncoprotein for solution structure studies by Charbonnier, Sebastian, Stier, Gunter, Orfanoudakis, Georges, Kieffer, Bruno, Atkinson, R. Andrew, Travé, Gilles

“…The oncoprotein E6 produced by tumorigenic high-risk genital human papillomaviruses targets a number of cellular proteins containing PDZ domains for…”
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