Search Results - "Charbonnier, Louis‐Marie"

Regulatory T Cells: the Many Faces of Foxp3 by Georgiev, Peter, Charbonnier, Louis-Marie, Chatila, Talal A.

“…Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a requisite role in the maintenance of immunological homeostasis and…”
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Functional reprogramming of regulatory T cells in the absence of Foxp3 by Charbonnier, Louis-Marie, Cui, Ye, Stephen-Victor, Emmanuel, Harb, Hani, Lopez, David, Bleesing, Jack J., Garcia-Lloret, Maria I., Chen, Karin, Ozen, Ahmet, Carmeliet, Peter, Li, Ming O., Pellegrini, Matteo, Chatila, Talal A.

“…Regulatory T cells (T reg cells) deficient in the transcription factor Foxp3 lack suppressor function and manifest an effector T (T eff ) cell–like phenotype…”
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Large scale regulatory T cells screening by Benamar, Mehdi, Charbonnier, Louis‐Marie

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Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma by Crestani, Elena, Harb, Hani, Charbonnier, Louis-Marie, Leirer, Jonathan, Motsinger-Reif, Alison, Rachid, Rima, Phipatanakul, Wanda, Kaddurah-Daouk, Rima, Chatila, Talal A.

“…Food allergy (FA) affects an increasing proportion of children for reasons that remain obscure. Novel disease biomarkers and curative treatment options are…”
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Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation by Weinacht, Katja G., MD, PhD, Charbonnier, Louis-Marie, PhD, Alroqi, Fayhan, MD, Plant, Ashley, MD, Qiao, Qi, PhD, Wu, Hao, PhD, Ma, Clement, PhD, Torgerson, Troy R., MD, PhD, Rosenzweig, Sergio D., MD, PhD, Fleisher, Thomas A., MD, Notarangelo, Luigi D., MD, Hanson, Imelda C., MD, Forbes, Lisa R., MD, Chatila, Talal A., MD, MSc

“…Background Gain-of-function (GOF) mutations in the human signal transducer and activator of transcription 1 (STAT1) manifest in immunodeficiency and…”
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A regulatory T cell Notch4–GDF15 axis licenses tissue inflammation in asthma by Harb, Hani, Stephen-Victor, Emmanuel, Crestani, Elena, Benamar, Mehdi, Massoud, Amir, Cui, Ye, Charbonnier, Louis-Marie, Arbag, Sena, Baris, Safa, Cunnigham, Amparito, Leyva-Castillo, Juan Manuel, Geha, Raif S., Mousavi, Amirhosein J., Guennewig, Boris, Schmitz-Abe, Klaus, Sioutas, Constantinos, Phipatanakul, Wanda, Chatila, Talal A.

“…Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision therapies. We found that interleukin-6- and STAT3 transcription…”
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The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries by van der Veeken, Joris, Glasner, Ariella, Zhong, Yi, Hu, Wei, Wang, Zhong-Min, Bou-Puerto, Regina, Charbonnier, Louis-Marie, Chatila, Talal A., Leslie, Christina S., Rudensky, Alexander Y.

“…Regulatory T (Treg) cell identity is defined by the lineage-specifying transcription factor (TF) Foxp3. Here we examined mechanisms of Foxp3 function by…”
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Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity by Turner, Jacob A., Stephen-Victor, Emmanuel, Wang, Sen, Rivas, Magali Noval, Abdel-Gadir, Azza, Harb, Hani, Cui, Ye, Fanny, Manoussa, Charbonnier, Louis-Marie, Fong, Jason Jun Hung, Benamar, Mehdi, Wang, Leighanne, Burton, Oliver T., Bansal, Kushagra, Bry, Lynn, Zhu, Chengsong, Li, Quan-Zhen, Clement, Rachel L., Oettgen, Hans C., Crestani, Elena, Rachid, Rima, Sage, Peter T., Chatila, Talal A.

“…The mechanisms by which regulatory T (Treg) cells differentially control allergic and autoimmune responses remain unclear. We show that Treg cells in food…”
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Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation by Alroqi, Fayhan J., Charbonnier, Louis-Marie, Baris, Safa, Kiykim, Ayca, Chou, Janet, Platt, Craig D., Algassim, Abdulrahman, Keles, Sevgi, Al Saud, Bandar K., Alkuraya, Fowzan S., Jordan, Michael, Geha, Raif S., Chatila, Talal A.

“…LPS-responsive beige-like anchor protein (LRBA) and cytotoxic T lymphocyte–associated antigen 4 (CTLA4) deficiencies give rise to overlapping phenotypes of…”
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Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections by Harb, Hani, Benamar, Mehdi, Lai, Peggy S., Contini, Paola, Griffith, Jason W., Crestani, Elena, Schmitz-Abe, Klaus, Chen, Qian, Fong, Jason, Marri, Luca, Filaci, Gilberto, Del Zotto, Genny, Pishesha, Novalia, Kolifrath, Stephen, Broggi, Achille, Ghosh, Sreya, Gelmez, Metin Yusuf, Oktelik, Fatma Betul, Cetin, Esin Aktas, Kiykim, Ayca, Kose, Murat, Wang, Ziwei, Cui, Ye, Yu, Xu G., Li, Jonathan Z., Berra, Lorenzo, Stephen-Victor, Emmanuel, Charbonnier, Louis-Marie, Zanoni, Ivan, Ploegh, Hidde, Deniz, Gunnur, De Palma, Raffaele, Chatila, Talal A.

“…A cardinal feature of COVID-19 is lung inflammation and respiratory failure. In a prospective multi-country cohort of COVID-19 patients, we found that…”
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Evolution and long‐term outcomes of combined immunodeficiency due to CARMIL2 deficiency by Kolukisa, Burcu, Baser, Dilek, Akcam, Bengu, Danielson, Jeffrey, Bilgic Eltan, Sevgi, Haliloglu, Yesim, Sefer, Asena Pinar, Babayeva, Royale, Akgun, Gamze, Charbonnier, Louis‐Marie, Schmitz‐Abe, Klaus, Kendir Demirkol, Yasemin, Zhang, Yu, Gonzaga‐Jauregui, Claudia, Jimenez Heredia, Raul, Kasap, Nurhan, Kiykim, Ayca, Ozek Yucel, Esra, Gok, Veysel, Unal, Ekrem, Pac Kisaarslan, Aysenur, Nepesov, Serdar, Baysoy, Gokhan, Onal, Zerrin, Yesil, Gozde, Celkan, Tulin Tiraje, Cokugras, Haluk, Camcioglu, Yildiz, Eken, Ahmet, Boztug, Kaan, Lo, Bernice, Karakoc‐Aydiner, Elif, Su, Helen C., Ozen, Ahmet, Chatila, Talal A., Baris, Safa

“…Background Biallelic loss‐of‐function mutations in CARMIL2 cause combined immunodeficiency associated with dermatitis, inflammatory bowel disease (IBD), and…”
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Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like disorder caused by loss-of-function mutations in LRBA by Charbonnier, Louis-Marie, PhD, Janssen, Erin, MD, PhD, Chou, Janet, MD, Ohsumi, Toshiro K., PhD, Keles, Sevgi, MD, Hsu, Joyce T., MD, Massaad, Michel J., PhD, Garcia-Lloret, Maria, MD, Hanna-Wakim, Rima, MD, Dbaibo, Ghassan, MD, Alangari, Abdullah A., MD, Alsultan, Abdulrahman, MD, Al-Zahrani, Daifulah, MD, Geha, Raif S., MD, Chatila, Talal A., MD, MSc

“…Background A number of heritable immune dysregulatory diseases result from defects affecting regulatory T (Treg) cell development, function, or both. They…”
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Essential functions of regulatory T cell TGF-β1 revealed by differential gene-targeting approaches by Stephen-Victor, Emmanuel, Cui, Ye, Wang, Ziwei, Benamar, Mehdi, Charbonnier, Louis-Marie, Chatila, Talal A.

“…[...]the phenotype of mice with Treg-cell-specific Tgfb1 exon 6 deletion would be the result of Treg cell depletion rather than their Tgfb1 deficiency. [...]we…”
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Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations by Zemmour, David, Charbonnier, Louis-Marie, Leon, Juliette, Six, Emmanuelle, Keles, Sevgi, Delville, Marianne, Benamar, Mehdi, Baris, Safa, Zuber, Julien, Chen, Karin, Neven, Benedicte, Garcia-Lloret, Maria I., Ruemmele, Frank M., Brugnara, Carlo, Cerf-Bensussan, Nadine, Rieux-Laucat, Frederic, Cavazzana, Marina, André, Isabelle, Chatila, Talal A., Mathis, Diane, Benoist, Christophe

“…FOXP3 deficiency in mice and in patients with immune dysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome results in fatal autoimmunity by…”
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CTLA-4 Haploinsufficiency in a Patient with an Autoimmune Lymphoproliferative Disorder by Kucuk, Zeynep Yesim, MD, Charbonnier, Louis-Marie, PhD, McMasters, Richard L., MD, Chatila, Talal, MD MSc, Bleesing, Jack J.H., MD PhD

“…Capsule Summary: - CTLA-4 haploinsufficiency appears to have characteristic histopathological findings that are distinct from ALPS. - Assessment of TFH, TFR…”
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Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanism by Djouad, Farida, Charbonnier, Louis-Marie, Bouffi, Carine, Louis-Plence, Pascale, Bony, Claire, Apparailly, Florence, Cantos, Céline, Jorgensen, Christian, Noël, Danièle

“…Mesenchymal stem cells (MSC) are of particular interest for their potential clinical use in tissue engineering as well as for their capacity to reduce the…”
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EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease by Thomas, David C., Charbonnier, Louis-Marie, Schejtman, Andrea, Aldhekri, Hasan, Coomber, Eve L., Dufficy, Elizabeth R., Beenken, Anne E., Lee, James C., Clare, Simon, Speak, Anneliese O., Thrasher, Adrian J., Santilli, Giorgia, Al-Mousa, Hamoud, Alkuraya, Fowzan S., Chatila, Talal A., Smith, Kenneth G.C.

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The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children by Benamar, Mehdi, Chen, Qian, Chou, Janet, Julé, Amélie M, Boudra, Rafik, Contini, Paola, Crestani, Elena, Lai, Peggy S, Wang, Muyun, Fong, Jason, Rockwitz, Shira, Lee, Pui, Chan, Tsz Man Fion, Altun, Ekin Zeynep, Kepenekli, Eda, Karakoc-Aydiner, Elif, Ozen, Ahmet, Boran, Perran, Aygun, Fatih, Onal, Pinar, Sakalli, Ayse Ayzit Kilinc, Cokugras, Haluk, Gelmez, Metin Yusuf, Oktelik, Fatma Betul, Cetin, Esin Aktas, Zhong, Yuelin, Taylor, Maria Lucia, Irby, Katherine, Halasa, Natasha B, Mack, Elizabeth H, Signa, Sara, Prigione, Ignazia, Gattorno, Marco, Cotugno, Nicola, Amodio, Donato, Geha, Raif S, Son, Mary Beth, Newburger, Jane, Agrawal, Pankaj B, Volpi, Stefano, Palma, Paolo, Kiykim, Ayca, Randolph, Adrienne G, Deniz, Gunnur, Baris, Safa, De Palma, Raffaele, Schmitz-Abe, Klaus, Charbonnier, Louis-Marie, Henderson, Lauren A, Chatila, Talal A

“…Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown…”
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Expanding the Clinical and Immunological Phenotypes and Natural History of MALT1 Deficiency by Sefer, Asena Pinar, Abolhassani, Hassan, Ober, Franziska, Kayaoglu, Basak, Bilgic Eltan, Sevgi, Kara, Altan, Erman, Baran, Surucu Yilmaz, Naz, Aydogmus, Cigdem, Aydemir, Sezin, Charbonnier, Louis-Marie, Kolukisa, Burcu, Azizi, Gholamreza, Delavari, Samaneh, Momen, Tooba, Aliyeva, Simuzar, Kendir Demirkol, Yasemin, Tekin, Saban, Kiykim, Ayca, Baser, Omer Faruk, Cokugras, Haluk, Gursel, Mayda, Karakoc-Aydiner, Elif, Ozen, Ahmet, Krappmann, Daniel, Chatila, Talal A., Rezaei, Nima, Baris, Safa

“…Purpose MALT1 deficiency is a combined immune deficiency characterized by recurrent infections, eczema, chronic diarrhea, and failure to thrive. Clinical and…”
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Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes by Ysebrant de Lendonck, Laure, Tonon, Sandrine, Nguyen, Muriel, Vandevenne, Patricia, Welsby, Iain, Martinet, Valerie, Molle, Céline, Charbonnier, Louis-Marie, Leo, Oberdan, Goriely, Stanislas

“…IFN regulatory factor (IRF) 3 plays a key role in innate responses against viruses. Herein we assessed its contribution to T-cell activation. We observed that…”
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