Etiology and Laboratory Abnormalities in Bacterial Meningitis in Neonates and Young Infants

We conducted a retrospective review of electronic medical records of all cases of bacterial meningitis in neonates and young infants at our institution from 2004 to 2014. Fifty-six cases were identified. The most common causative organism was group B streptococcus, followed by Escherichia coli and t...

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Bibliographic Details
Published in:	Clinics and practice Vol. 7; no. 2; p. 943
Main Authors:	Kotzbauer, David, Travers, Curtis, Shapiro, Craig, Charbonnet, Margaux, Cooley, Anthony, Andresen, Deborah, Frank, Gary
Format:	Journal Article
Language:	English
Published:	PAGEPress Publications, Pavia, Italy 21-04-2017 MDPI AG
Subjects:	Bacterial meningitis Brief Report laboratory abnormalities neonates serious bacterial infection young infants
Online Access:	Get full text
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Summary:	We conducted a retrospective review of electronic medical records of all cases of bacterial meningitis in neonates and young infants at our institution from 2004 to 2014. Fifty-six cases were identified. The most common causative organism was group B streptococcus, followed by Escherichia coli and then Listeria monocytogenes. Fortyfour of the 56 patients in the study had abnormalities of the blood white blood cell (WBC) count. The most common WBC count abnormalities were leukopenia and elevation of the immature to total (I:T) neutrophil ratio. Six patients in the case series lacked cerebrospinal fluid (CSF) pleocytosis. Overall, just 3 of the 56 patients had normal WBC count with differential, CSF WBC count, and urinalysis. Only 1 of the 56 patients was well appearing with all normal lab studies. Our study indicates that bacterial meningitis may occur without CSF pleocytosis but very infrequently occurs with all normal lab studies and well appearance.
ISSN:	2039-7283 2039-7275 2039-7283
DOI:	10.4081/cp.2017.943