Search Results - "Charafeddine, Rabab A"

Local control of intracellular microtubule dynamics by EB1 photodissociation by van Haren, Jeffrey, Charafeddine, Rabab A., Ettinger, Andreas, Wang, Hui, Hahn, Klaus M., Wittmann, Torsten

“…End-binding proteins (EBs) are adaptors that recruit functionally diverse microtubule plus-end-tracking proteins (+TIPs) to growing microtubule plus ends. To…”
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Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent by Krausz, Aimee E., BA, Adler, Brandon L., BA, Cabral, Vitor, PhD, Navati, Mahantesh, PhD, Doerner, Jessica, MS, Charafeddine, Rabab A., MSc, Chandra, Dinesh, PhD, Liang, Hongying, PhD, Gunther, Leslie, MSc, Clendaniel, Alicea, BS, Harper, Stacey, PhD, Friedman, Joel M., PhD, Nosanchuk, Joshua D., MD, Friedman, Adam J., MD

“…Abstract Burn wounds are often complicated by bacterial infection, contributing to morbidity and mortality. Agents commonly used to treat burn wound infection…”
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Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis by Mukherjee, Suranjana, Valencia, J. Daniel Diaz, Stewman, Shannon, Metz, Jeremy, Monnier, Sylvain, Rath, Uttama, Asenjo, Ana B., Charafeddine, Rabab A., Sosa, Hernando J., Ross, Jennifer L., Ma, Ao, Sharp, David J.

“…Fidgetin is a member of the AAA protein superfamily with important roles in mammalian development. Here we show that human Fidgetin is a potent microtubule…”
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Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration by Baker, Lisa, Tar, Moses, Kramer, Adam H, Villegas, Guillermo A, Charafeddine, Rabab A, Vafaeva, Olga, Nacharaju, Parimala, Friedman, Joel, Davies, Kelvin P, Sharp, David J

“…The microtubule (MT) cytoskeleton plays a critical role in axon growth and guidance. Here, we identify the MT-severing enzyme fidgetin-like 2 (FL2) as a…”
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pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells by Webb, Bradley A, Aloisio, Francesca M, Charafeddine, Rabab A, Cook, Jessica, Wittmann, Torsten, Barber, Diane L

“…Many lysosome functions are determined by a lumenal pH of ∼5.0, including the activity of resident acid-activated hydrolases. Lysosome pH (pHlys) is often…”
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Unique and redundant functions of integrins in the epidermis by Margadant, Coert, Charafeddine, Rabab A, Sonnenberg, Arnoud

“…The skin forms a barrier against the environment and protects us from mechanical trauma, pathogens, radiation, dehydration, and dangerous temperature…”
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Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH by Charafeddine, Rabab A., Cortopassi, Wilian A., Lak, Parnian, Tan, Ruensern, McKenney, Richard J., Jacobson, Matthew P., Barber, Diane L., Wittmann, Torsten

“…Tau, a member of the MAP2/tau family of microtubule-associated proteins, stabilizes and organizes axonal microtubules in healthy neurons. In neurodegenerative…”
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Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing by Charafeddine, Rabab A., Makdisi, Joy, Schairer, David, O'Rourke, Brian P., Diaz-Valencia, Juan D., Chouake, Jason, Kutner, Allison, Krausz, Aimee, Adler, Brandon, Nacharaju, Parimala, Liang, Hongying, Mukherjee, Suranjana, Friedman, Joel M., Friedman, Adam, Nosanchuk, Joshua D., Sharp, David J.

“…Wound healing is a complex process driven largely by the migration of a variety of distinct cell types from the wound margin into the wound zone. In this…”
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Local Control of Intracellular Microtubule Dynamics by EB1 Photo-Dissociation by van Haren, Jeffrey, Charafeddine, Rabab A., Ettinger, Andreas, Wang, Hui, Hahn, Klaus M., Wittmann, Torsten

“…End-binding proteins, EBs, are adaptors that recruit functionally diverse +TIP proteins to growing microtubule plus ends. To test with high spatial and…”
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