Search Results - "Chappuis, P.O."

Set-up of a population-based familial breast cancer registry in Geneva, Switzerland: validation of first results by Verkooijen, H. M., Fioretta, G., Chappuis, P. O., Vlastos, G., Sappino, A. P., Benhamou, S., Bouchardy, C.

“…Background: This article evaluates the accuracy of family history of breast and ovarian cancer among first-degree relatives of breast cancer patients,…”
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Primary node negative breast cancer in BRCA1 mutation carriers has a poor outcome by FOULKES, W. D, CHAPPUIS, P. O, BEGIN, L. R, WONG, N, BRUNET, J.-S, VESPRINI, D, ROZEN, F, YUAN, Z. Q, POLLAK, M. N, KUPERSTEIN, G, NAROD, S. A

“…The association between BRCA1 germ-line mutations and breast cancer prognosis is controversial. A historical cohort study was designed to determine the…”
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Breast cancer treatment and outcome in women ^50 years old with high familial risk by Rapiti, E, Verkooijen, H.M, Fioretta, G, Chappuis, P.O, Vlastos, G, Bouchardy, C

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Location of mutation in BRCA2 gene and survival in patients with ovarian cancer by Labidi-Galy, S.I., Olivier, T., Rodrigues, M., Ferraioli, D., Derbel, O., Bodmer, A., Petignat, P., Chopin, N., Tredan, O., Heudel, P., Viassolo, V., Ayme, A., Chappuis, P.O., Stern, M-H., Houdayer, C., Stoppa-Lyonnet, D., Buisson, A., Golmard, L., Bonadona, V., Ray-Coquard, I.

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A significant response to neoadjuvant chemotherapy in BRCA1/2 related breast cancer by Chappuis, P O, Goffin, J, Wong, N, Perret, C, Ghadirian, P, Tonin, P N, Foulkes, W D

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Hormonal therapy for oestrogen receptor-negative breast cancer is associated with higher disease-specific mortality by Merglen, A., Verkooijen, H.M., Fioretta, G., Neyroud-Caspar, I., Vinh-Hung, V., Vlastos, G., Chappuis, P.O., Castiglione, M., Rapiti, E., Bouchardy, C.

“…Tamoxifen has a remarkable impact on the outcome of oestrogen receptor (ER)-positive breast cancer. Without proven benefits, tamoxifen is occasionally…”
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Cyclin E expression in breast cancer: predicting germline BRCA1 mutations, prognosis and response to treatment by Chappuis, P. O., Donato, E., Goffin, J. R., Wong, N., Bégin, L. R., Kapusta, L. R., Brunet, J.-S., Porter, P., Foulkes, W. D.

“…Background:: Elevated levels of the cell cycle protein cyclin E, and low levels of its inhibitor, p27Kip1, have been associated with a poor prognosis following…”
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The influence of familial and hereditary factors on the prognosis of breast cancer by Chappuis, P. O., Rosenblatt, J., Foulkes, W. D.

“…Background: Family history is a well recognized risk factor for breast cancer, but its impact in terms of breast cancer survival is uncertain. The recent…”
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A polymorphism in the ATM gene modulates the penetrance of hereditary non‐polyposis colorectal cancer by Maillet, P., Chappuis, P.O., Vaudan, G., Dobbie, Z., Müller, H., Hutter, P., Sappino, A.‐P.

“…Germ‐line mutations in MLH1 and MSH2 genes predispose to hereditary non‐polyposis colorectal cancer (HNPCC) syndrome, but they do not predict a specific…”
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Constitutional alterations of the ATM gene in early onset sporadic breast cancer by Maillet, P, Bonnefoi, H, Vaudan-Vutskits, G, Pajk, B, Cufer, T, Foulkes, W D, Chappuis, P O, Sappino, A-P

“…After initial denaturation at 94°C for five minutes, each of the 35 cycles of amplification consisted of 30 seconds at 94°C, 30 seconds at optimal annealing…”
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A polymorphism in theATM gene modulates the penetrance of hereditary non-polyposis colorectal cancer by Maillet, P., Chappuis, P.O., Vaudan, G., Dobbie, Z., M ller, H., Hutter, P., Sappino, A.-P.

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Change in the penetrance of founder BRCA1/2 mutations? A retrospective cohort study by Foulkes, W D, Brunet, J-S, Wong, N, Goffin, J, Chappuis, P O

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Molecular and clinical characteristics in 32 families affected with familial adenomatous polyposis by Hutter, P., Rey-Berthod, C., Chappuis, P.O., Couturier, A., Membrez, V., Murphy, A., Joris, F., Schorderet, D. F., Delozier-Blanchet, C., Soravia, C.

“…Germ‐line mutations in the 5′ half of the Adenomatous Polyposis Coli (APC) gene are found in about 80% of the patients affected with familial adenomatous…”
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1296 Genetics and cancer: A multidisciplinary approach by Murphy, A., Chappuis, P.O., Keizer, I., Saugy, M., Archinard, M., Sappino, A.-P.

“…Recent developments in molecular genetics offer the perspective to screen asymptomatic individuals for alterations in cancer-predisposing genes. A consultation…”
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