Search Results - "Chappell, Phillip"

Diagnostic Trends and Prescription Patterns in Disruptive Mood Dysregulation Disorder and Bipolar Disorder by Findling, Robert L., Zhou, Xiaofeng, George, Prethibha, Chappell, Phillip B.

“…Disruptive mood dysregulation disorder (DMDD) was introduced in DSM-5 to distinguish a subset of chronically irritable youth who may be incorrectly diagnosed…”
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Efficacy and Safety of Adjunctive Oral Ziprasidone for Acute Treatment of Depression in Patients With Bipolar I Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial by SACHS, Gary S, ICE, Kathleen S, CHAPPELL, Phillip B, SCHWARTZ, Jeffrey H, GURTOVAYA, Oksana, VANDERBURG, Douglas G, KASUBA, Bryce

“…To assess efficacy and safety of adjunctive ziprasidone in subjects with bipolar depression treated with lithium, lamotrigine, or valproate. 298 adult…”
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Assessment of Suicidal Ideation and Behavior: Report of the International Society for CNS Clinical Trials and Methodology Consensus Meeting by Chappell, Phillip B, Stewart, Michelle, Alphs, Larry, DiCesare, Franco, DuBrava, Sarah, Harkavy-Friedman, Jill, Lim, Pilar, Ratcliffe, Sian, Silverman, Morton M, Targum, Steven D, Marder, Stephen R

“…To develop consensus recommendations for assessment of suicidal ideation/suicidal behavior (SI/SB) in clinical trials. Stakeholders from academia, industry,…”
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Lack of an Effect of Supratherapeutic Dose of Venlafaxine on Cardiac Repolarization in Healthy Subjects by Abbas, Richat, Riley, Steve, Nepal, Sunil, Bachinsky, Mary, Lee, Kimberly C., Chappell, Phillip B., Damle, Bharat

“…This single‐center, randomized, 3‐way crossover thorough QT study evaluated the effect of steady‐state supratherapeutic venlafaxine (Effexor) on cardiac…”
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4.7 EFFICACY OF METHYLPHENIDATE EXTENDED-RELEASE CHEWABLE TABLETS IN CHILDREN WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER: OPEN-LABEL, DOSE-OPTIMIZATION PERIOD OUTCOMES by Wigal, Sharon B., PhD, Childress, Ann Catherine, MD, Berry, Sally, MD, PhD, Belden, Heidi, PharmD, Chappell, Phillip B., MD, MBA, Wajsbrot, Dalia, Nagraj, Praneeta, Abbas, Richat, PhD, Palumbo, Donna R., PhD

“…Objectives: To further examine the efficacy and safety of open-label (OL) methylphenidate, extended-release chewable tablets (MPH ERCT; 20-60 mg) in children…”
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A Thorough QT Study to Evaluate the Effects of a Supratherapeutic Dose of Sertraline on Cardiac Repolarization in Healthy Subjects by Abbas, Richat, Riley, Steve, LaBadie, Robert R., Bachinsky, Mary, Chappell, Phillip B., Crownover, Penelope H., Damle, Bharat

“…The effect of steady‐state supratherapeutic sertraline (Zoloft) on QT interval was assessed in a single‐center, randomized, 3‐way crossover, double‐blind,…”
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A Placebo-Controlled Study of Guanfacine in the Treatment of Children With Tic Disorders and Attention Deficit Hyperactivity Disorder by Scahill, Larry, Chappell, Phillip B., Kim, Young S., Schultz, Robert T., Katsovich, Lily, Shepherd, Elizabeth, Arnsten, Amy F.T., Cohen, Donald J., Leckman, James F.

“…OBJECTIVE: This study evaluated the efficacy and safety of guanfacine in treating children with tic disorders and attention deficit hyperactivity disorder…”
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Is it easier to find what you are looking for if you think you know what it looks like? by Mundt, James C, Greist, John H, Jefferson, James W, Katzelnick, David J, DeBrota, David J, Chappell, Phillip B, Modell, Jack G

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Clinical and Sensorimotor Gating Effects of Ketamine in Normals by Duncan, Erica J., Madonick, Steven H., Parwani, Arti, Angrist, Burt, Rajan, Rajive, Chakravorty, Subhajit, Efferen, Toby R., Szilagyi, Sandor, Stephanides, Myrsini, Chappell, Phillip B., Gonzenbach, Stephen, Ko, Grant N., Rotrosen, John P.

“…The clinical similarities between PCP psychosis and schizophrenia have contributed importantly to the development of the glutamate hypothesis of schizophrenia…”
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Study Site Experiences and Attitudes Toward Prospective Assessments of Suicidal Ideation and Behavior in Clinical Trials: Results of an Internet-based Survey by Stewart, Michelle, Butler, Adam, Alphs, Larry, Chappell, Phillip B, Feltner, Douglas E, Lenderking, William R, Mahableshwarkar, Atul R, Makumi, Clare W, Dubrava, Sarah

“…The International Society for CNS Clinical Trials and Methodology Suicidal Ideation and Behavior Assessment Working Group conducted an online survey regarding…”
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Prospective assessment of suicidal ideation and behavior: an internet survey of pharmaceutical sponsor practices by Chappell, Phillip B, Mahableshwarkar, Atul R, Alphs, Larry D, Bangs, Mark E, Butler, Adam, DuBrava, Sarah J, Greist, John H, Lenderking, William R, Mundt, James C, Stewart, Michelle

“…To survey the current approaches of clinical trial sponsors in prospective suicidal ideation and behavior assessments and challenges encountered. An…”
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Guanfacine treatment of comorbid attention-deficit hyperactivity disorder and Tourette's syndrome: preliminary clinical experience by Chappell, P B, Riddle, M A, Scahill, L, Lynch, K A, Schultz, R, Arnsten, A, Leckman, J F, Cohen, D J

“…Many children with Tourette's syndrome (TS) are handicapped more by difficulties with inattention, impulsivity, and hyperactivity than by their tics. However,…”
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Cerebrospinal Fluid Biogenic Amines in Obsessive Compulsive Disorder, Tourette's Syndrome, and Healthy Controls by Leckman, James F, Goodman, Wayne K, Anderson, George M, Riddle, Mark A, Chappell, Phillip B, McSwiggan-Hardin, Maureen T, McDougle, Christopher J, Scahill, Lawrence D, Ort, Sharon I, Pauls, David L, Cohen, Donald J, Price, Lawrence H

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Impaired prepulse inhibition of acoustic startle in schizophrenia by Parwani, Arti, Duncan, Erica J., Bartlett, Elsa, Madonick, Steven H., Efferen, Toby R., Rajan, Rajive, Sanfilipo, Michael, Chappell, Phillip B., Chakravorty, Subhajit, Gonzenbach, Stephen, Ko, Grant N., Rotrosen, John P.

“…Background: Schizophrenics show deficits in sensorimotor gating, as measured by prepulse inhibition of acoustic startle (PPI). The goal of this investigation…”
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H3 receptor antagonism increases methylhistamine levels in the cerebrospinal fluid of dogs and healthy human volunteers by Soares, Holly, Wager, Travis T, Schmidt, Anne W, Sweeney, Francis J, McLellan, Thomas J, Nelson, Frederick R, Spracklin, Doug, Wang, Ellen Q, Faessel, Helene, Pinter, Garry W, Li, Xiaoxi, Chappell, Phillip B

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Acute changes in Cerebrospinal Fluid 5-HIAA following Oral Paroxetine Challenge in Healthy Humans by CARPENTER, Linda L, ANDERSON, George M, SINISCALCHI, Jason M, CHAPPELL, Phillip B, PRICE, Lawrence H

“…A number of studies have reported decreased human lumbar cerebrospinal fluid (CSF) concentrations of the major serotonin metabolite, 5-hydroxyindoleacetic acid…”
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Cover by Khan, Umar, Hammer, Gregory B., Duncan‐Azadi, Cassandra, Suzuki, Yasuyuki, Chiles, Deborah, Chime, Sunring, Chappell, Phillip

“…The cover image is based on the Research Article A randomized, double‐blind, dose‐controlled study of the use of dexmedetomidine alone for procedural sedation…”
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Cover by Khan, Umar, Hammer, Gregory B., Duncan‐Azadi, Cassandra, Suzuki, Yasuyuki, Chiles, Deborah, Chime, Sunring, Chappell, Phillip

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7.7 MENTAL HEALTH COMORBIDITY IN PEDIATRIC BIPOLAR DISORDER AND DMDD: IMPACT OF DMDD INTRODUCTION? by Saade, Yasmina, Findling, Robert L., George, Prethibha, Zhou, Xiaofeng, Chappell, Phillip B.

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Patterns of response to acute naloxone infusion in Tourette's syndrome by van Wattum, Pieter Joost, Chappell, Phillip B., Zelterman, Daniel, Scahill, Lawrence D., Leckman, James F.

“…The purpose of this study was to replicate findings from an earlier pilot study in which we found a dose‐related effect of the opioid antagonist naloxone on…”
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