Search Results - "Chappell, PB"

A Placebo-Controlled Study of Guanfacine in the Treatment of Children With Tic Disorders and Attention Deficit Hyperactivity Disorder by Scahill, Larry, Chappell, Phillip B., Kim, Young S., Schultz, Robert T., Katsovich, Lily, Shepherd, Elizabeth, Arnsten, Amy F.T., Cohen, Donald J., Leckman, James F.

“…OBJECTIVE: This study evaluated the efficacy and safety of guanfacine in treating children with tic disorders and attention deficit hyperactivity disorder…”
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Ziprasidone treatment of children and adolescents with Tourette's syndrome: a pilot study by Sallee, F R, Kurlan, R, Goetz, C G, Singer, H, Scahill, L, Law, G, Dittman, V M, Chappell, P B

“…To evaluate the efficacy and tolerability of ziprasidone in children and adolescents with Tourette's syndrome and chronic tic disorders. Twenty-eight patients…”
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Alterations in corticotropin-releasing factor-like immunoreactivity in discrete rat brain regions after acute and chronic stress by Chappell, PB, Smith, MA, Kilts, CD, Bissette, G, Ritchie, J, Anderson, C, Nemeroff, CB

“…Corticotropin releasing factor (CRF) may regulate endocrine, autonomic, and behavioral responses to stress. Evidence indicates that CRF-like immunoreactivity…”
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Impaired prepulse inhibition of acoustic startle in schizophrenia by Parwani, Arti, Duncan, Erica J., Bartlett, Elsa, Madonick, Steven H., Efferen, Toby R., Rajan, Rajive, Sanfilipo, Michael, Chappell, Phillip B., Chakravorty, Subhajit, Gonzenbach, Stephen, Ko, Grant N., Rotrosen, John P.

“…Background: Schizophrenics show deficits in sensorimotor gating, as measured by prepulse inhibition of acoustic startle (PPI). The goal of this investigation…”
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Clinical and Sensorimotor Gating Effects of Ketamine in Normals by Duncan, Erica J., Madonick, Steven H., Parwani, Arti, Angrist, Burt, Rajan, Rajive, Chakravorty, Subhajit, Efferen, Toby R., Szilagyi, Sandor, Stephanides, Myrsini, Chappell, Phillip B., Gonzenbach, Stephen, Ko, Grant N., Rotrosen, John P.

“…The clinical similarities between PCP psychosis and schizophrenia have contributed importantly to the development of the glutamate hypothesis of schizophrenia…”
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Guanfacine treatment of comorbid attention-deficit hyperactivity disorder and Tourette's syndrome: preliminary clinical experience by Chappell, P B, Riddle, M A, Scahill, L, Lynch, K A, Schultz, R, Arnsten, A, Leckman, J F, Cohen, D J

“…Many children with Tourette's syndrome (TS) are handicapped more by difficulties with inattention, impulsivity, and hyperactivity than by their tics. However,…”
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Risperidone treatment of children and adolescents with chronic tic disorders: a preliminary report by Lombroso, P J, Scahill, L, King, R A, Lynch, K A, Chappell, P B, Peterson, B S, McDougle, C J, Leckman, J F

“…The purpose of this trial was to investigate the short-term safety and efficacy of risperidone in the treatment of chronic tic disorders in children and…”
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Acute changes in Cerebrospinal Fluid 5-HIAA following Oral Paroxetine Challenge in Healthy Humans by CARPENTER, Linda L, ANDERSON, George M, SINISCALCHI, Jason M, CHAPPELL, Phillip B, PRICE, Lawrence H

“…A number of studies have reported decreased human lumbar cerebrospinal fluid (CSF) concentrations of the major serotonin metabolite, 5-hydroxyindoleacetic acid…”
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Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, Tourette's syndrome, and healthy controls by LECKMAN, J. F, GOODMAN, W. K, COHEN, D. J, PRICE, L. H, ANDERSON, G. M, RIDDLE, M. A, CHAPPELL, P. B, MCSWIGGAN-HARDIN, M. T, MCDOUGLE, C. J, SCAHILL, L. D, ORT, S. I, PAULS, D. L

“…To examine the role of noradrenergic, dopaminergic, and serotonergic mechanisms in the pathobiology of obsessive compulsive disorder (OCD) and Tourette's…”
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Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment by King, R A, Riddle, M A, Chappell, P B, Hardin, M T, Anderson, G M, Lombroso, P, Scahill, L

“…Self-injurious ideation or behavior appeared de novo or intensified during fluoxetine treatment of obsessive-compulsive disorder in six patients, age 10 to 17…”
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Patterns of response to acute naloxone infusion in Tourette's syndrome by van Wattum, Pieter Joost, Chappell, Phillip B., Zelterman, Daniel, Scahill, Lawrence D., Leckman, James F.

“…The purpose of this study was to replicate findings from an earlier pilot study in which we found a dose‐related effect of the opioid antagonist naloxone on…”
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The role of central oxytocin in obsessive compulsive disorder and related normal behavior by Leckman, J F, Goodman, W K, North, W G, Chappell, P B, Price, L H, Pauls, D L, Anderson, G M, Riddle, M A, McDougle, C J, Barr, L C

“…Oxytocin (OT) is a neurosecretory nonapeptide synthesized in hypothalamic cells, which project to widely distributed sites in the CNS as well as the…”
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Pharmacologic treatment of tic disorders by Scahill, L, Chappell, P B, King, R A, Leckman, J F

“…The approach to treating children and adolescents with tic disorders has evolved in recent years such that complete elimination of tics is no longer the…”
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Sequential use of opioid antagonists and agonists in Tourette's syndrome by Chappell, P B

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Cerebrospinal fluid dynorphin A[1-8] and beta-endorphin levels in Tourette's syndrome are unaltered by van Wattum, P J, Anderson, G M, Chappell, P B, Goodman, W K, Riddle, M A, Leckman, J F

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Videotape tic counts in the assessment of Tourette's syndrome: stability, reliability, and validity by Chappell, P B, McSwiggan-Hardin, M T, Scahill, L, Rubenstein, M, Walker, D E, Cohen, D J, Leckman, J F

“…We examined the short- and long-term temporal stability of tic counts to estimate the minimum length of videotape needed for a reliable index of overall tic…”
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Neuroendocrine and behavioral effects of the selective kappa agonist spiradoline in Tourette's syndrome: a pilot study by Chappell, P B, Leckman, J F, Scahill, L D, Hardin, M T, Anderson, G, Cohen, D J

“…To evaluate the role of opioids in Tourette's syndrome (TS), we performed a dose-response study of the behavioral and neuroendocrine effects of the selective…”
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Future therapies of Tourette syndrome by Chappell, P B, Scahill, L D, Leckman, J F

“…Currently available pharmacologic therapies for Tourette syndrome often are characterized by limited effectiveness and unacceptable side effect profiles. In…”
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Assessment of diurnal variation of cerebrospinal fluid tryptophan and 5-hydroxyindoleacetic acid in healthy human females by Kirwin, Paul D., Anderson, George M., Chappell, Phillip B., Saberski, Lloyd, Leckman, James F., Geracioti, Thomas D., Heninger, George R., Price, Lawrence H., McDougle, Christopher J.

“…The role of serotonin (5-HT) in the pathogenesis and treatment of major neuropsychiatric disorders, including mood and anxiety disorders, continues to be the…”
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Clozapine in the treatment of a young adolescent with schizophrenia by Jacobsen, L K, Walker, M C, Edwards, J E, Chappell, P B, Woolston, J L

“…Although recent reports have suggested that clozapine may be efficacious in the treatment of adolescents with schizophrenia, few studies have examined the use…”
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