Search Results - "Chappell, Mark"

Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute? by Chappell, Mark C

“…The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological regulation of blood pressure through peripheral and central…”
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Renin-Angiotensin System and Sex Differences in COVID-19: A Critical Assessment by Chappell, Mark C.

“…The current epidemic of corona virus disease (COVID-19) has resulted in an immense health burden that became the third leading cause of death and potentially…”
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COVID-19, ACE2, and the cardiovascular consequences by South, Andrew M, Diz, Debra I, Chappell, Mark C

“…The novel SARS coronavirus SARS-CoV-2 pandemic may be particularly deleterious to patients with underlying cardiovascular disease (CVD). The mechanism for…”
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Commentary for "Endocrine significance of SARS-CoV-2's Reliance on ACE2" by Chappell, Mark C

“…Key Words: COVID-19, SARS-CoV-2, ACE2, Angiotensin II, Angiotensin-(1-7)…”
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S1P (Site-1 Protease)-Induced Release of the Soluble Prorenin Receptor in Hypertension: Do All Roads Lead to Ang II (Angiotensin II)? by Chappell, Mark C.

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Emerging Evidence for a Functional Angiotensin-Converting Enzyme 2-Angiotensin-(1-7)-Mas Receptor Axis: More Than Regulation of Blood Pressure? by Chappell, Mark C

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Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data by South, Andrew M, Shaltout, Hossam A, Washburn, Lisa K, Hendricks, Alexa S, Diz, Debra I, Chappell, Mark C

“…Hypertension is the primary risk factor for cardiovascular disease that constitutes a serious worldwide health concern and a significant healthcare burden. As…”
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Concerns on the Specificity of Commercial ELISAs for the Measurement of Angiotensin (1–7) and Angiotensin II in Human Plasma by Chappell, Mark C., Pirro, Nancy T., South, Andrew M., Gwathmey, TanYa M.

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Hydrothermal Carbonization of Municipal Waste Streams by Berge, Nicole D, Ro, Kyoung S, Mao, Jingdong, Flora, Joseph R. V, Chappell, Mark A, Bae, Sunyoung

“…Hydrothermal carbonization (HTC) is a novel thermal conversion process that can be used to convert municipal waste streams into sterilized, value-added…”
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Role of estrogen in diastolic dysfunction by Zhao, Zhuo, Wang, Hao, Jessup, Jewell A, Lindsey, Sarah H, Chappell, Mark C, Groban, Leanne

“…The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women after menopause and may lead to heart failure. While evidence…”
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Hydrogen sulfide, then nitric oxide and vasoprotection by Chappell, Mark C

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Cardiorenal Syndrome and Heart Failure—Challenges and Opportunities by Yogasundaram, Haran, Chappell, Mark C., Braam, Branko, Oudit, Gavin Y.

“…Cardiorenal syndromes (CRS) describe concomitant bidirectional dysfunction of the heart and kidneys in which 1 organ initiates, perpetuates, and/or accelerates…”
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Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue by Ahmad, Sarfaraz, Simmons, Tony, Varagic, Jasmina, Moniwa, Norihito, Chappell, Mark C, Ferrario, Carlos M

“…Since angiotensin-(1-12) [Ang-(1-12)] is a non-renin dependent alternate precursor for the generation of cardiac Ang peptides in rat tissue, we investigated…”
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Gut dysbiosis and hypertension: is it cause or effect? by Cook, Katherine L., Chappell, Mark C.

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Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling by Lindsey, Sarah H., Liu, Liu, Chappell, Mark C.

“…•Activation of the estrogen receptor GPER relaxes Lewis female mesenteric arteries.•Vasorelaxation is partially dependent on endothelial production of nitric…”
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Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2.Lewis rats by Jessup, Jewell A, Lindsey, Sarah H, Wang, Hao, Chappell, Mark C, Groban, Leanne

“…The G protein-coupled estrogen receptor (GPER) is expressed in various tissues including the heart. Since the mRen2.Lewis strain exhibits salt-dependent…”
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Angiotensin-(1–7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2 by Alzayadneh, Ebaa M., Chappell, Mark C.

“…Angiotensin-(1–7) (Ang-(1–7))/AT7-Mas receptor axis is an alternative pathway within the renin–angiotensin system (RAS) that generally opposes the actions of…”
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Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats by Wang, Hao, Jessup, Jewell A, Zhao, Zhuo, Da Silva, Jaqueline, Lin, Marina, MacNamara, Lindsay M, Ahmad, Sarfaraz, Chappell, Mark C, Ferrario, Carlos M, Groban, Leanne

“…The cardioprotective effects of estrogen are well recognized, but the mechanisms remain poorly understood. Accumulating evidence suggests that the local…”
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Amiloride and the diabetic kidney by Chappell, Mark C

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Reply to "Letter to the editor: Angiotensin quantification by mass spectrometry" by Chappell, Mark C

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