Search Results - "Chappell, Lori J"

How safe is safe enough? Radiation risk for a human mission to Mars by Cucinotta, Francis A, Kim, Myung-Hee Y, Chappell, Lori J, Huff, Janice L

“…Astronauts on a mission to Mars would be exposed for up to 3 years to galactic cosmic rays (GCR)--made up of high-energy protons and high charge (Z) and energy…”
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Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma by Saha, Janapriya, Bae, Jinsung, Wang, Shih-Ya, Lu, Huiming, Chappell, Lori J, Gopal, Purva, Davis, Anthony J

“…Abstract Multiple pathways mediate the repair of DNA double-strand breaks (DSBs), with numerous mechanisms responsible for driving choice between the pathways…”
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Induction of Chromosomal Aberrations at Fluences of Less Than One HZE Particle per Cell Nucleus by Hada, Megumi, Chappell, Lori J., Wang, Minli, George, Kerry A., Cucinotta, Francis A.

“…The assumption of a linear dose response used to describe the biological effects of high-LET radiation is fundamental in radiation protection methodologies. We…”
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Of Men and Mice: Using Terrestrial Radiation Epidemiology Methods to Inform Analysis of Animal Models for Space Radiation Risk Assessment by Chappell, Lori J., Rahill, Katherine M., Elgart, S. Robin

“…Prediction of cancer risk from space radiation exposure is critical to ensure spaceflight crewmembers are adequately informed of the risks they face when…”
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Analysis of Flow Cytometry DNA Damage Response Protein Activation Kinetics after Exposure to X Rays and High-Energy Iron Nuclei by Chappell, Lori J., Whalen, Mary K., Gurai, Sheena, Ponomarev, Artem, Cucinotta, Francis A., Pluth, Janice M.

“…We developed a mathematical method to analyze flow cytometry data to describe the kinetics of γ-H2AX and pATF2 phosphorylation in normal human fibroblast cells…”
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Radiation Exposure and Mortality from Cardiovascular Disease and Cancer in Early NASA Astronauts by Elgart, S. Robin, Little, Mark P., Chappell, Lori J., Milder, Caitlin M., Shavers, Mark R., Huff, Janice L., Patel, Zarana S.

“…Understanding space radiation health effects is critical due to potential increased morbidity and mortality following spaceflight. We evaluated whether there…”
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Assessing Nonlinearity in Harderian Gland Tumor Induction Using Three Combined HZE-irradiated Mouse Datasets by Chappell, Lori J., Elgart, S. Robin, Milder, Caitlin M., Semones, Edward J.

“…Recently reported studies considering nonlinearity in the effects of low-dose space radiation have assumed a nontargeted mechanism. To date, few analyses have…”
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Defining the Biological Effectiveness of Components of High-LET Track Structure by Sridharan, Deepa M., Chappell, Lori J., Whalen, Mary K., Cucinotta, Francis A., Pluth, Janice M.

“…During space travel, astronauts are exposed to a wide array of high-linear energy transfer (LET) particles, with differing energies and resulting biological…”
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Updates to Astronaut Radiation Limits: Radiation Risks for Never-Smokers by Cucinotta, Francis A., Chappell, Lori J.

“…New epidemiology assessments of the life span study (LSS) of the atomic bomb survivors in Japan and of other exposed cohorts have been made by the U.S…”
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NASCA Report 2: Longitudinal Study of Relationship of Exposure to Space Radiation and Risk of Lens Opacity by Chylack, Leo T, Feiveson, Alan H., Peterson, Leif E., Tung, William H., Wear, Mary L., Marak, Lisa J., Hardy, Dale S., Chappell, Lori J., Cucinotta, Francis A.

“…The NASA Study of Cataract in Astronauts (NASCA) was designed to measure the impact of exposure to space radiation on progression rates of cortical, nuclear,…”
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Non-targeted effects and the dose response for heavy ion tumor induction by Cucinotta, Francis A, Chappell, Lori J

“…Non-targeted effects (NTE), including bystander effects in neighbor cells of cells directly hit by radiation tracks and genomic instability in the progeny of…”
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Cytogenetic biodosimetry using the blood lymphocytes of astronauts by George, Kerry A., Rhone, Jordan, Chappell, Lori J., Cucinotta, Francis A.

“…Cytogenetic analysis of peripheral blood lymphocytes is the most sensitive and reliable method currently available for in vivo assessment of the biological…”
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Radiation Carcinogenesis Risk Assessments for Never-smokers by Cucinotta, Francis A, Chappell, Lori J, Kim, Myung-Hee Y, Wang, Minli

“…ABSTRACTCigarette smoking, which is presently associated with more than 20% of adult deaths in the United States, is a large confounder to radiation risk…”
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Analysis of Flow Cytometry DNA Damage Response Protein Activation Kinetics Following X-rays and High Energy Iron Nuclei Exposure by Universities Space Research Association, Chappell, Lori J., Whalen, Mary K., Gurai, Sheena, Ponomarev, Artem, Cucinotta, Francis A., Pluth, Janice M.

“…We developed a mathematical method to analyze flow cytometry data to describe the kinetics of {gamma}H2AX and pATF2 phosphorylations ensuing various qualities…”
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How Safe Is Safe Enough? Radiation Risk for a Human Mission to Mars: e74988 by Cucinotta, Francis A, Kim, Myung-Hee Y, Chappell, Lori J, Huff, Janice L

“…Astronauts on a mission to Mars would be exposed for up to 3 years to galactic cosmic rays (GCR) - made up of high-energy protons and high charge (Z) and…”
Get full text