Short chain α-pyrones capable of potentiating penicillin G against Pseudomonas aeruginosa

[Display omitted] The dramatic increase in bacterial resistance over the past three decades has greatly reduced the effectiveness of nearly all clinical antibiotics, bringing infectious disease to the forefront as a dire threat to global health. To combat these infections, adjuvant therapies have em...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 30; no. 16; p. 127301
Main Authors:	Fields, Lauren, Craig, Whitney R., Huffine, Clair A., Allen, Catherine F., Bouthillette, Leah M., Chappell, Jacob C., Shumate, Jacob T., Wolfe, Amanda L.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 15-08-2020
Subjects:	Adjuvants Antibiotics Penicillin G Pseudopyronine A α-pyrones Adjuvants α-pyrones Antibiotics Pseudopyronine A Penicillin G
Online Access:	Get full text
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Summary:	[Display omitted] The dramatic increase in bacterial resistance over the past three decades has greatly reduced the effectiveness of nearly all clinical antibiotics, bringing infectious disease to the forefront as a dire threat to global health. To combat these infections, adjuvant therapies have emerged as a way to reactivate known antibiotics against resistant pathogens. Herein, we report the evaluation of simplified α-pyrone adjuvants capable of potentiating penicillin G against Pseudomonas aeruginosa, a Gram-negative pathogen whose multidrug-resistant strains have been labeled by the Centers for Disease Control and Prevention as a serious threat to public health.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2020.127301