Search Results - "Chappell, E"

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates by Østergaard, Michael E, Jackson, Michaela, Low, Audrey, E. Chappell, Alfred, G. Lee, Richard, Peralta, Rachel Q, Yu, Jinghua, Kinberger, Garth A, Dan, Amy, Carty, Rick, Tanowitz, Michael, Anderson, Patrick, Kim, Tae-Won, Fradkin, Linda, Mullick, Adam E, Murray, Sue, Rigo, Frank, Prakash, Thazha P, Bennett, C Frank, Swayze, Eric E, Gaus, Hans J, Seth, Punit P

“…Abstract We determined the effect of attaching palmitate, tocopherol or cholesterol to PS ASOs and their effects on plasma protein binding and on enhancing ASO…”
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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle by Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P

“…Abstract Enhancing the functional uptake of antisense oligonucleotide (ASO) in the muscle will be beneficial for developing ASO therapeutics targeting genes…”
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Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice by Chappell, Alfred E, Gaus, Hans J, Berdeja, Andres, Gupta, Ruchi, Jo, Minji, Prakash, Thazha P, Oestergaard, Michael, Swayze, Eric E, Seth, Punit P

“…Conjugation of antisense oligonucleotide (ASO) with a variety of distinct lipophilic moieties like fatty acids and cholesterol increases ASO accumulation and…”
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Single-Stranded siRNAs Activate RNAi in Animals by Lima, Walt F., Prakash, Thazha P., Murray, Heather M., Kinberger, Garth A., Li, Wenyu, Chappell, Alfred E., Li, Cheryl S., Murray, Susan F., Gaus, Hans, Seth, Punit P., Swayze, Eric E., Crooke, Stanley T.

“…The therapeutic utility of siRNAs is limited by the requirement for complex formulations to deliver them to tissues. If potent single-stranded RNAs could be…”
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Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease by Whiley, Luke, Chappell, Katie E, D'Hondt, Ellie, Lewis, Matthew R, Jiménez, Beatriz, Snowden, Stuart G, Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Swann, Jonathan R, Hye, Abdul, Lovestone, Simon, Legido-Quigley, Cristina, Holmes, Elaine

“…Both serotonergic signalling disruption and systemic inflammation have been associated with the pathogenesis of Alzheimer's disease (AD). The common…”
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Evaluation of Immortalized AVPV- and Arcuate-Specific Neuronal Kisspeptin Cell Lines to Elucidate Potential Mechanisms of Estrogen Responsiveness and Temporal Gene Expression in Females by Jacobs, Dakota C, Veitch, Rebecca E, Chappell, Patrick E

“…In females, ovarian estradiol modulates kisspeptin (Kiss-1) synthesis to act as an obligatory regulator of downstream gonadotropin release in vivo, via…”
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Clocks on top: The role of the circadian clock in the hypothalamic and pituitary regulation of endocrine physiology by Tonsfeldt, Karen J., Chappell, Patrick E.

“…► The review explores circadian influences on hypothalamic and pituitary endocrine function. ► Endocrine influence on the suprachiasmatic nucleus and…”
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Ontario Racehorse Death Registry, 2003–2015: Descriptive analysis and rates of mortality by Physick‐Sheard, P. W., Avison, A., Chappell, E., MacIver, M.

“…Summary Background The Province of Ontario maintains a registry of racehorse deaths occurring within 60 days of a race or trial entry that provides insight…”
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Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction by Chappell, Paul E., Garner, Lee I., Yan, Jun, Metcalfe, Clive, Hatherley, Deborah, Johnson, Steven, Robinson, Carol V., Lea, Susan M., Brown, Marion H.

“…CD6 is a transmembrane protein with an extracellular region containing three scavenger receptor cysteine rich (SRCR) domains. The membrane proximal domain of…”
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Circadian Clock Protein BMAL1 Is Necessary for Fertility and Proper Testosterone Production in Mice by Alvarez, J.D, Hansen, Amanda, Ord, Teri, Bebas, Piotr, Chappell, Patrick E, Giebultowicz, Jadwiga M, Williams, Carmen, Moss, Stuart, Sehgal, Amita

“…Although it is well established that the circadian clock regulates mammalian reproductive physiology, the molecular mechanisms by which this regulation occurs…”
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Structural basis for specificity and promiscuity in a carrier protein/enzyme system from the sulfur cycle by Grabarczyk, Daniel B., Chappell, Paul E., Johnson, Steven, Stelzl, Lukas S., Lea, Susan M., Berks, Ben C.

“…The bacterial Sox (sulfur oxidation) pathway is an important route for the oxidation of inorganic sulfur compounds. Intermediates in the Sox pathway are…”
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HEALTH CARE'S OTHER "BIG DEAL": DIRECT PRIMARY CARE REGULATION IN CONTEMPORARY AMERICAN HEALTH LAW by Chappell, Glenn E.

“…Direct primary care is a promising, market-based alternative to the fee-for-service payment structure that shapes doctor–patient relationships in America…”
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Voluntary Surveillance Program for Equine Influenza Virus in the United States during 2008-2021 by Chappell, Duane E, Barnett, D Craig, James, Kaitlyn, Craig, Bryant, Bain, Fairfield, Gaughan, Earl, Schneider, Chrissie, Vaala, Wendy, Barnum, Samantha M, Pusterla, Nicola

“…A voluntary upper respiratory biosurveillance program in the USA received 9740 nasal swab submissions during the years 2008-2021 from 333 veterinarians and…”
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Autocrine production of reproductive axis neuropeptides affects proliferation of canine osteosarcoma in vitro by Weinman, Marcus A, Fischer, Jacob A, Jacobs, Dakota C, Goodall, Cheri P, Bracha, Shay, Chappell, Patrick E

“…Osteosarcoma strikes hundreds of people each year, of both advanced and younger ages, and is often terminal. Like many tumor types, these bone tumors will…”
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Dietary resveratrol increases mid-life fecundity of female Nothobranchius guentheri by Lee, Youngjoo, Drake, Andrew C., Thomas, Nicholas O., Ferguson, Lindsey G., Chappell, Patrick E., Shay, Kate Petersen

“…The decline of female reproductive function is an early phenotype of aging in humans, occurring only midway through the lifespan. Yet the number of women…”
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Circadian Gene Expression Regulates Pulsatile Gonadotropin-Releasing Hormone (GnRH) Secretory Patterns in the Hypothalamic GnRH-Secreting GT1-7 Cell Line by Chappell, Patrick E, White, Rachel S, Mellon, Pamela L

“…Although it has long been established that episodic secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus is required for normal…”
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Comparison of computed tomographic angiography with digital subtraction angiography in the diagnosis of cerebral aneurysms: a meta-analysis by Chappell, E Thomas, Moure, Federico Castro, Good, Matthew C

“…To compare a novel diagnostic radiological technique, computed tomographic angiography (CTA), with the standard method, namely digital subtraction angiography…”
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Characterization of Equine Rhinitis B Virus Infection in Clinically Ill Horses in the United States during the Period 2012–2023 by Schneider, Chrissie, James, Kaitlyn, Craig, Bryant W, Chappell, Duane E, Vaala, Wendy, van Harreveld, Philip D, Wright, Cara A, Barnum, Samantha, Pusterla, Nicola

“…Equine rhinitis B virus is a lesser-known equine respiratory pathogen that is being detected with increasing frequency via a voluntary upper respiratory…”
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Voluntary Biosurveillance of Streptococcus equi Subsp. equi in Nasal Secretions of 9409 Equids with Upper Airway Infection in the USA by Jaramillo-Morales, Camilo, James, Kaitlyn, Barnum, Samantha, Vaala, Wendy, Chappell, Duane E, Schneider, Chrissie, Craig, Bryant, Bain, Fairfield, Barnett, D Craig, Gaughan, Earl, Pusterla, Nicola

“…This study aimed to describe selected epidemiological aspects of horses with acute onset of fever and respiratory signs testing qPCR-positive for and to…”
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Clocks and the Black Box: Circadian Influences on Gonadotropin-Releasing Hormone Secretion by Chappell, P. E.

“…Although the mechanisms underlying hypothalamic surge secretion of gonadotropin‐releasing hormone (GnRH) in rodent models have remained enduring mysteries in…”
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