Search Results - "Chappell, Craig P"

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness by Suthar, Mehul S., Ramos, Hilario J., Brassil, Margaret M., Netland, Jason, Chappell, Craig P., Blahnik, Gabriele, McMillan, Aimee, Diamond, Michael S., Clark, Edward A., Bevan, Michael J., Gale, Michael

“…The RIG-I-like receptors (RLRs) signal innate immune defenses upon RNA virus infection, but their roles in adaptive immunity have not been clearly defined…”
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CD22 is required for formation of memory B cell precursors within germinal centers by Chappell, Craig P, Draves, Kevin E, Clark, Edward A

“…CD22 is a BCR co-receptor that regulates B cell signaling, proliferation and survival and is required for T cell-independent Ab responses. To investigate the…”
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Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory by Chaplin, Jay W, Chappell, Craig P, Clark, Edward A

“…Antigen (Ag) targeting is an efficient way to induce immune responses. Ag is usually coupled to an antibody (Ab) specific for a receptor expressed on dendritic…”
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Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells by Giltiay, Natalia V, Chappell, Craig P, Sun, Xizhang, Kolhatkar, Nikita, Teal, Thomas H, Wiedeman, Alice E, Kim, Jinoh, Tanaka, Lena, Buechler, Matthew B, Hamerman, Jessica A, Imanishi-Kari, Thereza, Clark, Edward A, Elkon, Keith B

“…Toll-like receptor (TLR), a ligand for single-stranded RNA, has been implicated in the development of pathogenic anti-RNA autoantibodies both in systemic lupus…”
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Controlling immune responses by targeting antigens to dendritic cell subsets and B cells by Chappell, Craig P, Giltiay, Natalia V, Dresch, Christiane, Clark, Edward A

“…Delivering antigens in vivo by coupling them to mAbs specific for unique receptors on antigen-presenting cells (APCs) is a promising approach for modulating…”
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Targeting antigens through blood dendritic cell antigen 2 on plasmacytoid dendritic cells promotes immunologic tolerance by Chappell, Craig P, Giltiay, Natalia V, Draves, Kevin E, Chen, ChangHung, Hayden-Ledbetter, Martha S, Shlomchik, Mark J, Kaplan, Daniel H, Clark, Edward A

“…The C-type lectin receptor blood dendritic cell Ag 2 (BDCA2) is expressed exclusively on human plasmacytoid DCs (pDCs) and plays a role in Ag capture,…”
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Immune complex-mediated enhancement of secondary antibody responses by Goins, Chelsey L, Chappell, Craig P, Shashidharamurthy, Rangaiah, Selvaraj, Periasamy, Jacob, Joshy

“…Immunologic memory is a hallmark of the vertebrate immune system. The first antigenic exposure leads to a slow and modest immune response, whereas repeated…”
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Identification of Memory B Cells Using a Novel Transgenic Mouse Model by Chappell, Craig P, Jacob, Joshy

“…Memory B cells help to protect the host from invading pathogens by maintaining persistent levels of Ag-specific serum Ab and generating rapid Ab responses upon…”
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Interleukin-10 plays an early role in generating virus-specific T cell anergy by Maris, Charles H, Chappell, Craig P, Jacob, Joshy

“…Infection of mice with the Armstrong strain of lymphocytic choriomeningitis virus (LCMVARM) leads to a robust immune response and efficient viral clearance…”
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Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses by Chappell, Craig P, Draves, Kevin E, Giltiay, Natalia V, Clark, Edward A

“…Dendritic cells (DCs) are best known for their ability to activate naive T cells, and emerging evidence suggests that distinct DC subsets induce specialized T…”
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CD28-B7 interaction modulates short- and long-lived plasma cell function by Njau, Modesta N, Kim, Jin Hyang, Chappell, Craig P, Ravindran, Rajesh, Thomas, Leela, Pulendran, Bali, Jacob, Joshy

“…The interaction of CD28, which is constitutively expressed on T cells, with B7.1/B7.2 expressed on APCs is critical for T cell activation. CD28 is also…”
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Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators by Methot, Joey L, Zhou, Hua, McGowan, Meredeth A, Anthony, Neville John, Christopher, Matthew, Garcia, Yudith, Achab, Abdelghani, Lipford, Kathryn, Trotter, Benjamin Wesley, Altman, Michael D, Fradera, Xavier, Lesburg, Charles A, Li, Chaomin, Alves, Stephen, Chappell, Craig P, Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybill M. G, Goldenblatt, Peter, Hill, Armetta, Shaffer, Lynsey, Chen, Dapeng, Tong, Vincent, McLeod, Robbie L, Lee, Hyun-Hee, Yu, Hongshi, Shah, Sanjiv, Katz, Jason D

“…The approvals of idelalisib and duvelisib have validated PI3Kδ inhibitors for the treatment for hematological malignancies driven by the PI3K/AKT pathway. Our…”
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B-cell selection and the development of autoantibodies by Giltiay, Natalia V, Chappell, Craig P, Clark, Edward A

“…The clearest evidence that B cells play an important role in human autoimmunity is that immunotherapies that deplete B cells are very effective treatments for…”
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STALing B cell responses with CD22 by Chappell, Craig P, Clark, Edward A

“…Suppressing unwanted humoral immune responses without compromising the host's ability to respond to foreign pathogens is a primary goal for therapies aimed at…”
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Germinal-center-derived B-cell memory by Chappell, Craig P, Jacob, Joshy

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Survival niches: B cells get MIFed as well as BAFFled by dendritic cells by Chappell, Craig P, Clark, Edward A

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Ontogeny of the secondary antibody response: origins and clonal diversity by Chappell, Craig P, Dauner, Joseph, Jacob, Joshy

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Perfusion fixation preserves enhanced yellow fluorescent protein and other cellular markers in lymphoid tissues by Dauner, Joseph G., Chappell, Craig P., Williams, Ifor R., Jacob, Joshy

“…Fluorescent proteins are increasingly being used to analyze cellular gene expression and to facilitate tracking of cell lineages in vivo. One of these,…”
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Introduction: the complexities of T-cell heterogeneity by Chappell, Craig P., Jacob, Joshy

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Abstract 2254: Solid tumor activity with a selective PI3Kdelta inhibitor as a single agent and in combination with anti-PD-1 by Methot, Joey L., Zhou, Hua, McGowan, Meredith A., Trotter, Benjamin W., Altman, Michael, Fradera, Xavier, Lesburg, Charles, Li, Chaomin, Alves, Stephen, Chappell, Craig P., Jain, Renu, Mangado, Ruban, Pinheiro, Elaine, Williams, Sybil M., Goldenblatt, Peter, Hill, Armetta D., Shaffer, Lynsey, Chen, Dapeng, McLeod, Robbie L., Lee, Hyun-Hee, Shah, Sanjiv, Katz, Jason D.

“…Abstract Inhibitors of PI3Kdelta are approved as monotherapy for the treatment of hematologic malignancies such as follicular B-cell non-Hodgkin lymphoma,…”
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