Search Results - "Chappell, Ann"

Adolescent Rearing Conditions Influence the Relationship Between Initial Anxiety-Like Behavior and Ethanol Drinking in Male Long Evans Rats by Chappell, Ann M., Carter, Eugenia, McCool, Brian A., Weiner, Jeff L.

“…Background Rodent studies have demonstrated that adolescent social isolation results in many behavioral perturbations, including increases in anxiety‐like…”
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Chronic Intermittent Ethanol Exposure Modulation of Glutamatergic Neurotransmission in Rat Lateral/Basolateral Amygdala is Duration-, Input-, and Sex-Dependent by Morales, Melissa, McGinnis, Molly M., Robinson, Stacey L., Chappell, Ann M., McCool, Brian A.

“…•Males and females show anxiety after 3–10 days of ethanol vapor exposure.•Stria terminalis presynaptic facilitation requires 3–7 days of ethanol…”
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Early Social Isolation in Male Long-Evans Rats Alters Both Appetitive and Consummatory Behaviors Expressed During Operant Ethanol Self-Administration by McCool, Brian A., Chappell, Ann M.

“…Background:  Postweaning social isolation in rats produces profound and long‐lasting cognitive and behavioral deficits in adult animals. Importantly, this…”
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Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress by Rau, Andrew R, Chappell, Ann M, Butler, Tracy R, Ariwodola, Olusegun J, Weiner, Jeff L

“…Adolescence represents a particularly vulnerable period during which exposure to stressors can precipitate the onset of psychiatric disorders and addiction…”
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Chronic intermittent ethanol inhalation increases ethanol self-administration in both C57BL/6J and DBA/2J mice by McCool, Brian A, Chappell, Ann M

“…Abstract Inbred mouse strains provide significant opportunities to understand the genetic mechanisms controlling ethanol-directed behaviors and neurobiology…”
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Chemogenetic inhibition of a monosynaptic projection from the basolateral amygdala to the ventral hippocampus selectively reduces appetitive, but not consummatory, alcohol drinking‐related behaviours by Bach, Eva C., Ewin, Sarah E., Heaney, Chelcie F., Carlson, Hannah N., Ortelli, Olivia A., Almonte, Antoine G., Chappell, Ann M., Raab‐Graham, Kimberly F., Weiner, Jeffrey L.

“…Alcohol use disorder (AUD) and anxiety/stressor disorders frequently co‐occur and this dual diagnosis represents a major health and economic problem worldwide…”
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Optogenetically-induced tonic dopamine release from VTA-nucleus accumbens projections inhibits reward consummatory behaviors by Mikhailova, Maria A, Bass, Caroline E, Grinevich, Valentina P, Chappell, Ann M, Deal, Alex L, Bonin, Keith D, Weiner, Jeff L, Gainetdinov, Raul R, Budygin, Evgeny A

“…Highlights • Tonic dopamine increases in rat nucleus accumbens can be optogenetically mimicked. • Increase in tonic accumbal dopamine release results in…”
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Chronic Ethanol Differentially Modulates Glutamate Release from Dorsal and Ventral Prefrontal Cortical Inputs onto Rat Basolateral Amygdala Principal Neurons by McGinnis, Molly M, Parrish, Brian C, Chappell, Ann M, Alexander, Nancy J, McCool, Brian A

“…The medial prefrontal cortex (mPFC) and the basolateral amygdala (BLA) have strong reciprocal connectivity. Projections from the BLA to the mPFC can drive…”
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Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral/basolateral amygdala by Diaz, Marvin R, Chappell, Ann M, Christian, Daniel T, Anderson, Nancy J, McCool, Brian A

“…Central among the brain regions that regulate fear/anxiety behaviors is the lateral/basolateral amygdala (BLA). BLA output is tightly controlled by the…”
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Chronic Methylphenidate Treatment During Early Life Is Associated with Greater Ethanol Intake in Socially Isolated Rats by Gill, Kathryn E., Chappell, Ann M., Beveridge, Thomas J. R., Porrino, Linda J., Weiner, Jeffrey L.

“…Background Methylphenidate (MPH) is a stimulant prescribed to treat attention‐deficit/ hyperactivity disorder. Its primary mechanism of action is in the…”
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Chronic Ethanol and Withdrawal Differentially Modulate Pre- and Postsynaptic Function at Glutamatergic Synapses in Rat Basolateral Amygdala by Lack, Anna K, Diaz, Marvin R, Chappell, Ann, DuBois, Dustin W, McCool, Brian A

“…1 Department of Physiology and Pharmacology, 2 Alcohol Training Program, and 3 Neuroscience Training Program, Wake Forest University School of Medicine,…”
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Lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the anxiolytic effects of beta 3 adrenoceptor activation by Silberman, Yuval, Ariwodola, Olusegun J, Chappell, Ann M, Yorgason, Jordan T, Weiner, Jeff L

“…Norepinephrine (NE) is known to play an integral role in the neurobiological response to stress. Exposure to stressful stimuli increases NE levels in brain…”
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Lateral Paracapsular GABAergic Synapses in the Basolateral Amygdala Contribute to the Anxiolytic Effects of β3 Adrenoceptor Activation by SILBERMAN, Yuval, ARIWODOLA, Olusegun J, CHAPPELL, Ann M, YORGASON, Jordan T, WEINER, Jeff L

“…Norepinephrine (NE) is known to play an integral role in the neurobiological response to stress. Exposure to stressful stimuli increases NE levels in brain…”
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Persistent enhancement of ethanol drinking following a monosodium glutamate-substitution procedure in C57BL6/J and DBA/2J mice by McCool, Brian A, Chappell, Ann M

“…Abstract Inbred mouse strains such as C57BL/6J (B6) and DBA/2J (D2) and related strains have been used extensively to help identify genetic controls for a…”
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Lateral/basolateral amygdala serotonin type-2 receptors modulate operant self-administration of a sweetened ethanol solution via inhibition of principal neuron activity by McCool, Brian A, Christian, Daniel T, Fetzer, Jonathan A, Chappell, Ann M

“…The lateral/basolateral amygdala (BLA) forms an integral part of the neural circuitry controlling innate anxiety and learned fear. More recently, BLA dependent…”
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Using monosodium glutamate to initiate ethanol self-administration in inbred mouse strains by McCool, Brian A., Chappell, Ann M.

“…ABSTRACT Voluntary oral ethanol consumption in rodents is generally limited by strong taste‐aversion in these species. Historically, this has been overcome by…”
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Dopamine D3-Like Receptors Modulate Anxiety-Like Behavior and Regulate GABAergic Transmission in the Rat Lateral Basolateral Amygdala by DIAZ, Marvin R, CHAPPELL, Ann M, CHRISTIAN, Daniel T, ANDERSON, Nancy J, MCCOOL, Brian A

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Neurobiological mechanisms contributing to alcohol–stress–anxiety interactions by Silberman, Yuval, Bajo, Michal, Chappell, Ann M, Christian, Daniel T, Cruz, Maureen, Diaz, Marvin R, Kash, Thomas, Lack, Anna K, Messing, Robert O, Siggins, George R, Winder, Danny, Roberto, Marisa, McCool, Brian A, Weiner, Jeff L

“…Abstract This article summarizes the proceedings of a symposium that was presented at a conference entitled “Alcoholism and Stress: A Framework for Future…”
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Relationship Between Ethanol's Acute Locomotor Effects and Ethanol Self-Administration in Male Long-Evans Rats by Chappell, Ann M., Weiner, Jeff L.

“…Background:  Human studies have suggested an important relationship between ethanol sensitivity and risk of alcoholism. These studies have led some to…”
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Effects of Raclopride in the Nucleus Accumbens on Ethanol Seeking and Consumption by Czachowski, Cristine L., Chappell, Ann M., Samson, Herman H.

“…Background: Nucleus accumbens dopamine has been shown to play a role in the processing of behaviorally relevant stimuli and to mediate ethanol‐reinforced…”
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