Search Results - "Chappel, C I"

Sucrose Acetate Isobutyrate (SAIB): Historical Aspects of its use in Beverages and a Review of Toxicity Studies Prior to 1988 by REYNOLDS, R.C., CHAPPEL, C.I.

“…Sucrose acetate isobutyrate (SAIB), a mixture of esters of sucrose with a composition approximating the name sucrose diacetate hexaisobutyrate, has been used…”
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Subchronic Toxicity Study of Tetrahydroisohumulone and Hexahydroisohumulone in the Beagle Dog by Chappel, C.I, Smith, S.Y, Chagnon, M

“…Hops and hop extracts are approved and widely used bittering agents in the brewing of beer. During recent years, preisomerized α hop acids and reduced…”
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4-Week Range-finding and 1-Year Oral Toxicity Studies of Sucrose Acetate Isobutyrate (SAIB) in the Cynomolgus Monkey by BLAIR, M., CHAPPEL, C.I.

“…Sucrose acetate isobutyrate (SAIB) is used as an emulsion stabilizer in citrus-based soft drinks. A 4-week range-finding study and a 1-year chronic toxicity…”
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Subchronic toxicity studies of sucrose acetate isobutyrate (SAIB) in the rat and dog by PROCTER, B. G, CHAPPEL, C. I

“…Preliminary short-term toxicity studies of sucrose acetate isobutyrate (SAIB) in the dog demonstrated that addition of this additive to the diet was associated…”
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Effect of Sucrose Acetate Isobutyrate (SAIB) Ingestion on the Hepatobiliary Function of Normal Human Male and Female Volunteers by CHIANG, M., GRAY, K., CHAPPEL, C.I.

“…A study of the effects of sucrose acetate isobutyrate (SAIB) ingestion was conducted in 13 male and 14 female healthy human volunteers. SAIB, in a gum…”
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Oral Toxicity and Carcinogenicity Studies of Sucrose Acetate Isobutyrate (SAIB) in the Fischer 344 Rat and B6C3F1 Mouse by MacKENZIE, K.M., TISDEL, P.J., HALL, R.L., BOYSEN, B.G., FIELD, W.E., CHAPPEL, C.I.

“…Sucrose acetate isobutyrate (SAIB), a food additive used as a flavour emulsion stabilizer in citrus-based soft drinks, was evaluated for chronic toxicity in…”
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A review and biological risk assessment of sodium saccharin by Chappel, C I

“…Dietary sodium saccharin is associated with bladder tumors when fed at high levels to the male rat. Under these conditions urinary pH, sodium concentration,…”
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Caramel colours--a historical introduction by Chappel, C I, Howell, J C

“…Caramel colours used in the manufacture of a wide variety of foods and beverages have been an item of commerce for more than one hundred years. The regulatory…”
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Sucrose Acetate Isobutyrate (SAIB): Three-generation Reproduction Study in the Rat and Teratology Studies in the Rat and Rabbit by MACKENZIE, K.M., HENWOOD, S.M., TISDEL, P.J., BOYSEN, B.G., PALMER, T.E., SCHARDEIN, J.L., WEST, A.J., CHAPPEL, C.I.

“…A three-generation reproduction study of sucrose acetate isobutyrate (SAIB) in Fischer 344 rats and teratology studies in Fischer 344 rats and New Zealand…”
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The spontaneously diabetic Wistar rat. Metabolic and morphologic studies by Nakhooda, A. F., Like, A. A., Chappel, C. I., Murray, F. T., Marliss, E. B.

“…The spontaneously diabetic Wistar rat. Metabolic and morphologic studies. A F Nakhooda , A A Like , C I Chappel , F T Murray and E B Marliss Abstract A new,…”
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The spontaneously diabetic Wistar rat. Metabolic and morphologic studies by Nakhooda, A F, Like, A A, Chappel, C I, Murray, F T, Marliss, E B

“…A new, spontaneously diabetic syndrome has been recognized in nonobese outbred Wistar rats of both sexes. The age at detection of first glycosuria has varied…”
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The effect of pyridoxine on the number of lymphocytes in the blood of rats fed caramel colour (III) by Sinkeldam, E J, de Groot, A P, van den Berg, H, Chappel, C I

“…The effect of vitamin E, folic acid, pyridoxine (vitamin B6) and choline on the reduction in circulating lymphocytes in the blood of rats fed Caramel Colour…”
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Absorption, distribution and excretion of the colour fraction of Caramel Colour IV in the rat by Selim, S, Chappel, C I, Schoenig, G P

“…Caramel Colour IV prepared from [U-14C]glucose was ultrafiltered in order to isolate the high molecular weight colour fraction (HMCF). The colour fraction that…”
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The discovery and development of the BB rat colony: an animal model of spontaneous diabetes mellitus by Chappel, C I, Chappel, W R

“…The BB rat model of spontaneous diabetes mellitus was discovered in 1974 in Ottawa in a colony of specific pathogen-free Wistar rats. Investigations to…”
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Toxicity and carcinogenicity studies of Caramel Colour IV in F344 rats and B6C3F1 mice by MacKenzie, K M, Boysen, B G, Field, W E, Petsel, S R, Chappel, C I, Emerson, J L, Stanley, J

“…Caramel Colour IV, a type of caramel colour used in the manufacture of cola soft drinks, was evaluated for subchronic and chronic toxicity in rats, and…”
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The spontaneously diabetic Wistar rat (the "BB" rat). Studies prior to and during development of the overt syndrome by Nakhooda, A F, Like, A A, Chappel, C I, Wei, C N, Marliss, E B

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Toxicity studies of Caramel Colour III and 2-acetyl-4(5)-tetrahydroxybutylimidazole in F344 rats by MacKenzie, K M, Boysen, B G, Field, W E, Petsel, S R, Chappel, C I, Emerson, J L, Stanley, J

“…Caramel Colour III is used as a colour additive in beers and a variety of foods. Beer is the most important single source of Caramel Colour III in the diet…”
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Saccharin revisited by Chappel, C I

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Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography by Cohen, S M, Fisher, M J, Sakata, T, Cano, M, Schoenig, G P, Chappel, C I, Garland, E M

“…Three methods used to detect proliferative changes in the rat urothelium, light microscopy, scanning electron microscopy, and autoradiography, were compared…”
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Subchronic toxicity study of Caramel Colour II in F344 rats by MacKenzie, K M, Carter, J L, Petsel, S R, Chappel, C I, Emerson, J L, Stanley, J

“…Caramel Colour II is a distinct type of colourant with a pronounced reddish hue. It is made with sulphite reactants but without ammonia. The red colour and a…”
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