Search Results - "Chapp, Andrew D."

Acetic Acid: An Underestimated Metabolite in Ethanol-Induced Changes in Regulating Cardiovascular Function by Chapp, Andrew D, Shan, Zhiying, Chen, Qing-Hui

“…Acetic acid is a bioactive short-chain fatty acid produced in large quantities from ethanol metabolism. In this review, we describe how acetic acid/acetate…”
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Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell by Johnson, Caroline S, Chapp, Andrew D, Lind, Erin B, Thomas, Mark J, Mermelstein, Paul G

“…The nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cortex (ILC) to the shell region of the…”
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Expression of Proinflammatory Cytokines Is Upregulated in the Hypothalamic Paraventricular Nucleus of Dahl Salt-Sensitive Hypertensive Rats by Jiang, Enshe, Chapp, Andrew D, Fan, Yuanyuan, Larson, Robert A, Hahka, Taija, Huber, Michael J, Yan, Jianqun, Chen, Qing-Hui, Shan, Zhiying

“…Accumulating evidence indicates that inflammation is implicated in hypertension. However, the role of brain proinflammatory cytokines (PICs) in salt sensitive…”
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Fundamental Sex Differences in Cocaine-Induced Plasticity of Dopamine D1 Receptor– and D2 Receptor–Expressing Medium Spiny Neurons in the Mouse Nucleus Accumbens Shell by Chapp, Andrew D., Nwakama, Chinonso A., Jagtap, Pramit P., Phan, Chau-Mi H., Thomas, Mark J., Mermelstein, Paul G.

“…Cocaine-induced plasticity in the nucleus accumbens shell of males occurs primarily in dopamine D1 receptor–expressing medium spiny neurons (D1R-MSNs), with…”
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Long-Term High Salt Intake Involves Reduced SK Currents and Increased Excitability of PVN Neurons with Projections to the Rostral Ventrolateral Medulla in Rats by Shan, Zhiying, Cheng, Zixi (Jack), Wang, Renjun, Chapp, Andrew D., Chen, Qing-Hui

“…Evidence indicates that high salt (HS) intake activates presympathetic paraventricular nucleus (PVN) neurons, which contributes to sympathoexcitation of…”
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The ethanol metabolite acetic acid activates mouse nucleus accumbens shell medium spiny neurons by Chapp, Andrew D, Mermelstein, Paul G, Thomas, Mark J

“…Although ethanol consumption leads to an array of neurophysiological alterations involving the neural circuits for reward, the underlying mechanisms remain…”
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Physiological acetic acid concentrations from ethanol metabolism stimulate accumbens shell medium spiny neurons via NMDAR activation in a sex-dependent manner by Chapp, Andrew D, Nwakama, Chinonso A, Collins, Andréa R, Mermelstein, Paul G, Thomas, Mark J

“…Recent studies have implicated the ethanol metabolite, acetic acid, as neuroactive, perhaps even more so than ethanol itself. In this study, we investigated…”
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Ethanol Metabolite, Acetate, Increases Excitability of the Central Nucleus of Amygdala Neurons through Activation of NMDA Receptors by Chapp, Andrew D., Collins, Andréa R., Driscoll, Kyle M., Behnke, Jessica E., Shan, Zhiying, Zhang, Li, Chen, Qing-Hui

“…The central nucleus of the amygdala (CeA) is a key brain region involved in emotional and stressor responses due to its many projections to autonomic…”
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Caveolin-1 regulates medium spiny neuron structural and functional plasticity by Eisinger, Katherine R. Tonn, Chapp, Andrew D., Swanson, Samuel P., Tam, Daniel, Lopresti, Natalie M., Larson, Erin B., Thomas, Mark J., Lanier, Lorene M., Mermelstein, Paul G.

“…Rationale Caveolin-1 (CAV1) is a structural protein critical for spatial organization of neuronal signaling molecules. Whether CAV1 is required for…”
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Elevated L-lactate Promotes Major Cellular Pathologies Associated with Neurodegenerative Diseases by Chapp, Andrew D., Behnke, Jessica E., Driscoll, Kyle M., Hahka, Taija, LaLonde, Zoe, Shan, Zhiying, Chen, Qing-Hui

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Sympathoexcitation and pressor responses induced by ethanol in the central nucleus of amygdala involves activation of NMDA receptors in rats by Chapp, Andrew D, Gui, Le, Huber, Michael J, Liu, Jinling, Larson, Robert A, Zhu, Jianhua, Carter, Jason R, Chen, Qing-Hui

“…The central nervous system plays an important role in regulating sympathetic outflow and arterial pressure in response to ethanol exposure. However, the…”
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Acetate Mediates Alcohol Excitotoxicity in Dopaminergic-like PC12 Cells by Chapp, Andrew D, Behnke, Jessica E, Driscoll, Kyle M, Fan, Yuanyuan, Hoban, Eileen, Shan, Zhiying, Zhang, Li, Chen, Qing-Hui

“…Neuronal excitotoxicity is the major cause of alcohol-related brain damage, yet the underlying mechanism remains poorly understood. Using dopaminergic-like…”
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High Salt Intake Augments Excitability of PVN Neurons in Rats: Role of the Endoplasmic Reticulum Ca2+ Store by Larson, Robert A., Chapp, Andrew D., Gui, Le, Huber, Michael J., Cheng, Zixi Jack, Shan, Zhiying, Chen, Qing-Hui

“…High salt (HS) intake sensitizes central autonomic circuitry leading to sympathoexcitation. However, its underlying mechanisms are not fully understood. We…”
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Sympathoexcitation in ANG II-salt hypertension involves reduced SK channel function in the hypothalamic paraventricular nucleus by Larson, Robert A, Gui, Le, Huber, Michael J, Chapp, Andrew D, Zhu, Jianhua, LaGrange, Lila P, Shan, Zhiying, Chen, Qing-Hui

“…Hypertension (HTN) resulting from subcutaneous infusion of ANG II and dietary high salt (HS) intake involves sympathoexcitation. Recently, we reported reduced…”
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Measurement of cations, anions, and acetate in serum, urine, cerebrospinal fluid, and tissue by ion chromatography by Chapp, Andrew D., Schum, Simeon, Behnke, Jessica E., Hahka, Taija, Huber, Michael J., Jiang, Enshe, Larson, Robert A., Shan, Zhiying, Chen, Qing‐Hui

“…Accurate quantification of cations and anions remains a major diagnostic tool in understanding diseased states. The current technologies used for these…”
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Sympathoexcitation and pressor responses induced by acetate, an ethanol metabolite in the hypothalamic paraventricular nucleus involves activation of NMDA receptors in rats by Bruning, Jessica, Chapp, Andrew D., Miodonski, Greg, Gu, Mingjun, Shan, Zhiying, Chen, Qinghui

“…Abstract only Alcohol abuse plays a crucial role in the prevalence of cardiovascular and neuronal degenerated diseases. However, the central mechanism that…”
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Microbial Derived Short Chain Fatty‐Acids and Autonomic Regulation of Cardiovascular Function by Bruning, Jessica Rae, Ghannam, Ryan B., Chen, Qing-hui, Shan, Zhiying, Miodonski, Gregory, Techtmann, Stephen, Chapp, Andrew D.

“…Abstract only…”
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Nicotine Attenuates Acetate‐Induced Increase of Cytosolic Reactive Oxygen Species in Dopaminergic‐Like PC12 Cells by Behnke, Jessica E., Chapp, Andrew D., Shan, Zhiying, Chen, Qing‐Hui

“…We have previously reported that the major ethanol metabolite, acetate (6 mM), significantly (p<0.05) increases levels of cytosolic calcium in neural growth…”
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L‐lactate Increases Apoptosis in Dopaminergic‐Like PC12 Cells by LaLonde, Zoë M, Behnke, Jessica E, Chapp, Andrew D, Shan, Zhiying Jenny, Chen, Qing Hui

“…Lactate has been shown to be excitatory through activation of ligand gated calcium channels. Studies have demonstrated that extracellular lactate is capable of…”
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Acetate, the Metabolite of Ethanol, Increases Cytosolic Calcium and mRNA Expression Levels of EGR1 and TNFα in Dopaminergic Like PC12 Cells by Behnke, Jessica E., Chapp, Andrew D., Driscoll, Kyle M., Shan, Zhiying, Chen, Qinghui

“…Abstract only We have previously reported that acetate activates NMDAR in vivo and in vitro, increases pro‐inflammatory cytokine mRNA expression, and cytosolic…”
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