Search Results - "Chapo, Joseph"

Canonical Transient Receptor Potential Channels Promote Cardiomyocyte Hypertrophy through Activation of Calcineurin Signaling by Bush, Erik W., Hood, David B., Papst, Philip J., Chapo, Joseph A., Minobe, Wayne, Bristow, Michael R., Olson, Eric N., McKinsey, Timothy A.

“…The calcium/calmodulin-dependent phosphatase calcineurin plays a central role in the control of cardiomyocyte hypertrophy in response to pathological stimuli…”
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A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase by Monovich, Lauren, Vega, Richard B., Meredith, Erik, Miranda, Karl, Rao, Chang, Capparelli, Michael, Lemon, Douglas D., Phan, Dillon, Koch, Keith A., Chapo, Joseph A., Hood, David B., McKinsey, Timothy A.

“…Class IIa histone deacetylases (HDACs) repress genes involved in pathological cardiac hypertrophy. The anti-hypertrophic action of class IIa HDACs is overcome…”
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Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1 by Monovich, Lauren, Koch, Keith A., Burgis, Robin, Osimboni, Ekundayo, Mann, Thierry, Wall, Daniel, Gao, Jinhai, Feng, Yan, Vega, Richard B., Turner, Benjamin A., Hood, David B., Law, Andy, Papst, Philip J., Koditek, David, Chapo, Joseph A., Reid, Brian G., Melvin, Lawrence S., Pagratis, Nikos C., McKinsey, Timothy A.

“…Histone deacetylase 5 (HDAC5) represses expression of nuclear genes that promote cardiac hypertrophy. Agonism of a variety of G protein coupled receptors…”
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Meiotic Recombination Provokes Functional Activation of the p53 Regulatory Network by Lu, Wan-Jin, Chapo, Joseph, Roig, Ignasi, Abrams, John M.

“…The evolutionary appearance of p53 protein probably preceded its role in tumor suppression, suggesting that there may be unappreciated functions for this…”
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Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D by Meredith, Erik L, Beattie, Kimberly, Burgis, Robin, Capparelli, Michael, Chapo, Joseph, DiPietro, Lucian, Gamber, Gabriel, Enyedy, Istvan, Hood, David B, Hosagrahara, Vinayak, Jewell, Charles, Koch, Keith A, Lee, Wendy, Lemon, Douglas D, McKinsey, Timothy A, Miranda, Karl, Pagratis, Nikos, Phan, Dillon, Plato, Craig, Rao, Chang, Rozhitskaya, Olga, Soldermann, Nicolas, Springer, Clayton, van Eis, Maurice, Vega, Richard B, Yan, Wanlin, Zhu, Qingming, Monovich, Lauren G

“…The synthesis and biological evaluation of potent and selective PKD inhibitors are described herein. The compounds described in the present study selectively…”
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Histone deacetylase inhibition (HDACi) attenuates catecholamine‐induced impairments in contractile reserve by Liles, John Thomas, Joly, Kristin M., Ida, Kevin K, Chapo, Joseph, Plato, Craig F.

“…Chronic catecholamine excess is a well‐characterized model of cardiac hypertrophy and dysfunction. We recently demonstrated adult, non‐senescent rats have…”
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Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat by Liles, John T, Ida, Kevin K, Joly, Kristin M, Chapo, Joseph, Plato, Craig F

“…Contractile reserve decreases with advancing age and chronic isoproterenol (ISO) administration is a well-characterized model of cardiac hypertrophy known to…”
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Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats by Cavasin, Maria A, Semus, Hillary, Pitts, Kelly, Peng, Yanyu, Sandoval, Jennifer, Chapo, Joseph, Plato, Craig F

“…Hepatic and circulating endothelin-1 (ET-1) are increased in patients with cirrhosis and in cirrhotic animals. However, the distinct roles of ET receptor…”
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Age exacerbates chronic catecholamine‐induced impairments in contractile reserve by Liles, John Thomas, Ida, Kevin, Joly, Kristin, Chapo, Joseph, Peng, Yanyu, Plato, Craig F

“…Abstract only Heart failure is more prevalent and impaired contractile reserve develops with advancing age. This study evaluated whether adult, non‐senescent…”
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A phosphorimager-based filter binding thyroid hormone receptor competition assay for chemical screening by Chapo, Joseph, Peng, Yanyu, Pitts, Kelly R.

“…A phosphorimager-based filter binding thyroid hormone receptor (THR) competition assay has been developed for use in verifying hits from compound library…”
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