Search Results - "Chapnik, Elik"

miRNA malfunction causes spinal motor neuron disease by Haramati, Sharon, Chapnik, Elik, Sztainberg, Yehezkel, Eilam, Raya, Zwang, Raaya, Gershoni, Noga, McGlinn, Edwina, Heiser, Patrick W., Wills, Anne-Marie, Wirguin, Itzhak, Rubin, Lee L., Misawa, Hidemi, Tabin, Clifford J., Brown, Robert, Chen, Alon, Hornstein, Eran

“…Defective RNA metabolism is an emerging mechanism involved in ALS pathogenesis and possibly in other neurodegenerative disorders. Here, we show that microRNA…”
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MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis by Goljanek-Whysall, Katarzyna, Sweetman, Dylan, Abu-Elmagd, Muhammad, Chapnik, Elik, Dalmay, Tamas, Hornstein, Eran, Münsterberg, Andrea

“…Commitment of progenitors in the dermomyotome to myoblast fate is the first step in establishing the body musculature. Pax3 is a crucial transcription factor,…”
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Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis by Mildner, Alexander, Chapnik, Elik, Manor, Ohad, Yona, Simon, Kim, Ki-Wook, Aychek, Tegest, Varol, Diana, Beck, Gilad, Itzhaki, Zohar Barnett, Feldmesser, Ester, Amit, Ido, Hornstein, Eran, Jung, Steffen

“…The mononuclear phagocyte system comprises cells as diverse as monocytes, macrophages, and dendritic cells (DCs), which collectively play key roles in innate…”
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miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis by Chapnik, Elik, Rivkin, Natalia, Mildner, Alexander, Beck, Gilad, Pasvolsky, Ronit, Metzl-Raz, Eyal, Birger, Yehudit, Amir, Gail, Tirosh, Itay, Porat, Ziv, Israel, Liron L, Lellouche, Emmanuel, Michaeli, Shulamit, Lellouche, Jean-Paul M, Izraeli, Shai, Jung, Steffen, Hornstein, Eran

“…Genome-encoded microRNAs (miRNAs) provide a posttranscriptional regulatory layer that controls the differentiation and function of various cellular systems,…”
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MicroRNA‐142 controls thymocyte proliferation by Mildner, Alexander, Chapnik, Elik, Varol, Diana, Aychek, Tegest, Lampl, Nardi, Rivkin, Natalia, Bringmann, Anita, Paul, Franziska, Boura‐Halfon, Sigalit, Hayoun, Yifat Segal, Barnett‐Itzhaki, Zohar, Amit, Ido, Hornstein, Eran, Jung, Steffen

“…T‐cell development is a spatially and temporally regulated process, orchestrated by well‐defined contributions of transcription factors and cytokines. Here, we…”
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Brief report: miR‐290–295 regulate embryonic stem cell differentiation propensities by repressing pax6 by Kaspi, Haggai, Chapnik, Elik, Levy, Maayan, Beck, Gilad, Hornstein, Eran, Soen, Yoav

“…microRNAs of the miR‐290–295 family are selectively expressed at high levels in mouse embryonic stem cells (mESCs) and have established roles in regulating…”
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Erythrocyte survival is controlled by microRNA-142 by Rivkin, Natalia, Chapnik, Elik, Mildner, Alexander, Barshtein, Gregory, Porat, Ziv, Kartvelishvily, Elena, Dadosh, Tali, Birger, Yehudit, Amir, Gail, Yedgar, Saul, Izraeli, Shai, Jung, Steffen, Hornstein, Eran

“…Hematopoietic-specific microRNA-142 is a critical regulator of various blood cell lineages, but its role in erythrocytes is unexplored. Herein, we characterize…”
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Rac1 functions downstream of miR-142 in regulation of erythropoiesis by Rivkin, Natalia, Chapnik, Elik, Birger, Yehudit, Yanowski, Eran, Curato, Caterina, Mildner, Alexander, Porat, Ziv, Amir, Gail, Izraeli, Shai, Jung, Steffen, Hornstein, Eran

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Dgcr8 controls neural crest cells survival in cardiovascular development by Chapnik, Elik, Sasson, Vered, Blelloch, Robert, Hornstein, Eran

“…DiGeorge syndrome (DGS), characterized genetically by a deletion within chromosome 22q11.2, is associated with a constellation of congenital heart defects…”
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RNA viruses can hijack vertebrate microRNAs to suppress innate immunity by Trobaugh, Derek W., Gardner, Christina L., Sun, Chengqun, Haddow, Andrew D., Wang, Eryu, Chapnik, Elik, Mildner, Alexander, Weaver, Scott C., Ryman, Kate D., Klimstra, William B.

“…Here it is proposed that RNA viruses can adapt to use the antiviral properties of microRNAs to limit viral replication and suppress innate immunity in…”
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Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS by Eitan, Chen, Siany, Aviad, Barkan, Elad, Olender, Tsviya, van Eijk, Kristel R., Moisse, Matthieu, Farhan, Sali M. K., Danino, Yehuda M., Yanowski, Eran, Marmor-Kollet, Hagai, Rivkin, Natalia, Yacovzada, Nancy Sarah, Hung, Shu-Ting, Cooper-Knock, Johnathan, Yu, Chien-Hsiung, Louis, Cynthia, Masters, Seth L., Kenna, Kevin P., van der Spek, Rick A. A., Sproviero, William, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Jones, Ashley R., Elbaz-Alon, Yael, Cohen, Yahel, Chapnik, Elik, Rothschild, Daphna, Weissbrod, Omer, Beck, Gilad, Ainbinder, Elena, Ben-Dor, Shifra, Werneburg, Sebastian, Schafer, Dorothy P., Brown, Robert H., Shaw, Pamela J., Van Damme, Philip, van den Berg, Leonard H., Phatnani, Hemali, Segal, Eran, Ichida, Justin K., Al-Chalabi, Ammar, Veldink, Jan H., Hornstein, Eran

“…The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association studies. Here, we performed…”
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Efficiency and specificity in microRNA biogenesis by Barad, Omer, Mann, Mati, Chapnik, Elik, Shenoy, Archana, Blelloch, Robert, Barkai, Naama, Hornstein, Eran

“…Primary microRNA cleavage by the Microprocessor complex comprising Drosha and DGCR8 needs to be specific yet efficient. Mathematical modeling complemented with…”
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Efficiency and specificity in micro RNA biogenesis by Barad, Omer, Mann, Mati, Chapnik, Elik, Shenoy, Archana, Blelloch, Robert, Barkai, Naama, Hornstein, Eran

“…Primary microRNA cleavage by the Drosha–Dgcr8 ‘Microprocessor’ complex is critical for microRNA biogenesis. Yet, the Microprocessor may also cleave other…”
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Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3'UTR protect against ALS by Eitan, Chen, Siany, Aviad, Barkan, Elad, Olender, Tsviya, van Eijk, Kristel R, Moisse, Matthieu, Farhan, Sali M K, Danino, Yehuda M, Yanowski, Eran, Marmor-Kollet, Hagai, Rivkin, Natalia, Yacovzada, Nancy Sarah, Hung, Shu-Ting, Cooper-Knock, Johnathan, Yu, Chien-Hsiung, Louis, Cynthia, Masters, Seth L, Kenna, Kevin P, van der Spek, Rick A A, Sproviero, William, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Jones, Ashley R, Elbaz-Alon, Yael, Cohen, Yahel, Chapnik, Elik, Rothschild, Daphna, Weissbrod, Omer, Beck, Gilad, Ainbinder, Elena, Ben-Dor, Shifra, Werneburg, Sebastian, Schafer, Dorothy P, Brown, Jr, Robert H, Shaw, Pamela J, Van Damme, Philip, van den Berg, Leonard H, Phatnani, Hemali, Segal, Eran, Ichida, Justin K, Al-Chalabi, Ammar, Veldink, Jan H, Hornstein, Eran

“…The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association studies. Here, we performed…”
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microRNA Function in Developmental Systems by Chapnik, Elik

“…microRNAs (miRNAs) are genome-encoded short RNAs that post-transcriptionally repress gene expression by base-pairing to the mRNAs of protein-coding genes…”
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06-P033 Ablation of Dgcr8 in neural crest cells leads to cardiovascular defects reminiscent of DiGeorge syndrome by Chapnik, Elik, Blelloch, Robert, Hornstein, Eran

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