Search Results - "Chapman, Sinead B"
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The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum
Published in Nature genetics (01-09-2012)“…Jane Carlton and colleagues report the genome sequencing, de novo assembly and annotation of four Plasmodium vivax reference strains from diverse geographic…”
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Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal
Published in PLoS medicine (01-09-2015)“…The continued advance of antibiotic resistance threatens the treatment and control of many infectious diseases. This is exemplified by the largest global…”
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Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events
Published in Science (American Association for the Advancement of Science) (05-02-2021)“…Analysis of 772 complete severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from early in the Boston-area epidemic revealed numerous…”
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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
Published in Science (American Association for the Advancement of Science) (12-09-2014)“…In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78…”
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Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks
Published in Proceedings of the National Academy of Sciences - PNAS (31-01-2017)“…Carbapenem-resistant Enterobacteriaceae (CRE) are among the most severe threats to the antibiotic era. Multiple different species can exhibit resistance due to…”
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Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance
Published in Nature genetics (01-03-2017)“…Ashlee Earl and colleagues analyze whole-genome sequences from 5,310 Mycobacterium tuberculosis isolates from five continents. They find that resistance to…”
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Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
Published in Nature genetics (01-05-2022)“…We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome sequencing of 13,933 patients with bipolar disorder (BD) matched with…”
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Increasing diversity in genomics requires investment in equitable partnerships and capacity building
Published in Nature genetics (01-06-2022)“…Calls for diversity in genomics have motivated new global research collaborations across institutions with highly imbalanced resources. We describe practical…”
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Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations
Published in American journal of human genetics (01-04-2021)“…Genetic studies in underrepresented populations identify disproportionate numbers of novel associations. However, most genetic studies use genotyping arrays…”
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Extensive global movement of multidrug-resistant M. tuberculosis strains revealed by whole-genome analysis
Published in Thorax (01-09-2019)“…While the international spread of multidrug-resistant (MDR) strains is an acknowledged public health threat, a broad and more comprehensive examination of the…”
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Phylogenomic Classification and the Evolution of Clonal Complex 5 Methicillin-Resistant Staphylococcus aureus in the Western Hemisphere
Published in Frontiers in microbiology (22-08-2018)“…Clonal complex 5 methicillin-resistant (CC5-MRSA) includes multiple prevalent clones that cause hospital-associated infections in the Western Hemisphere. Here,…”
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Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics
Published in Science (American Association for the Advancement of Science) (01-10-2010)“…Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, as…”
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Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections
Published in BMC microbiology (18-02-2021)“…Urinary tract infections (UTIs) affect 15 million women each year in the United States, with > 20% experiencing frequent recurrent UTIs. A recent…”
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Whole-Genome Sequencing of Mycobacterium tuberculosis Provides Insight into the Evolution and Genetic Composition of Drug-Resistant Tuberculosis in Belarus
Published in Journal of clinical microbiology (01-02-2017)“…The emergence and spread of drug-resistant Mycobacterium tuberculosis (DR-TB) are critical global health issues. Eastern Europe has some of the highest…”
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Pathogenomics of Culex quinquefasciatus and Meta-Analysis of Infection Responses to Diverse Pathogens
Published in Science (American Association for the Advancement of Science) (01-10-2010)“…The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm…”
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Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women
Published in Nature microbiology (01-05-2022)“…Recurrent urinary tract infections (rUTIs) are a major health burden worldwide, with history of infection being a significant risk factor. While the gut is a…”
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Inter-species geographic signatures for tracing horizontal gene transfer and long-term persistence of carbapenem resistance
Published in Genome medicine (05-04-2022)“…Carbapenem-resistant Enterobacterales (CRE) are an urgent global health threat. Inferring the dynamics of local CRE dissemination is currently limited by our…”
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Rare coding variants in ten genes confer substantial risk for schizophrenia
Published in Nature (London) (21-04-2022)“…Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes…”
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Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry
Published in Molecular psychiatry (01-10-2020)“…Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of millions of individuals worldwide. While rare genetic variants…”
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Draft Genome Sequences of Two Extensively Drug-Resistant Strains of Mycobacterium tuberculosis Belonging to the Euro-American S Lineage
Published in Genome announcements (Washington, DC) (03-03-2016)“…We report the whole-genome sequencing of two extensively drug-resistant tuberculosis strains belonging to the Euro-American S lineage. The RSA 114 strain…”
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