Responsiveness to endurance training can be partly explained by the number of favorable single nucleotide polymorphisms an individual possesses

Responsiveness to endurance training can be partly explained by the number of favorable single nucleotide polymorphisms an individual possesses

Cardiorespiratory fitness is a key component of health-related fitness. It is a necessary focus of improvement, especially for those that have poor fitness and are classed as untrained. However, much research has shown individuals respond differentially to identical training programs, suggesting the...

Full description

Saved in:
Bibliographic Details
Published in:PloS one Vol. 18; no. 7; p. e0288996
Main Authors: Chung, Henry C, Keiller, Don R, Swain, Patrick M, Chapman, Shaun L, Roberts, Justin D, Gordon, Dan A
Format: Journal Article
Language:English
Published: United States Public Library of Science 20-07-2023
Public Library of Science (PLoS)
Subjects:
Alleles
Analysis
Biology and Life Sciences
Body mass
Body mass index
Body size
Cardiorespiratory fitness
COVID-19
Endurance
Exercise
Exercise intensity
Fitness training programs
Genes
Genotype
Genotype & phenotype
Global positioning systems
GPS
Health aspects
Influence
Intervention
Medicine and Health Sciences
Nucleotides
Physical fitness
Physical training
Saliva
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Training
United Kingdom
United Kingdom > UK
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiorespiratory fitness is a key component of health-related fitness. It is a necessary focus of improvement, especially for those that have poor fitness and are classed as untrained. However, much research has shown individuals respond differentially to identical training programs, suggesting the involvement of a genetic component in individual exercise responses. Previous research has focused predominantly on a relatively low number of candidate genes and their overall influence on exercise responsiveness. However, examination of gene-specific alleles may provide a greater level of understanding. Accordingly, this study aimed to investigate the associations between cardiorespiratory fitness and an individual's genotype following a field-based endurance program within a previously untrained population. Participants (age: 29 ± 7 years, height: 175 ± 9 cm, mass: 79 ± 21 kg, body mass index: 26 ± 7 kg/m2) were randomly assigned to either a training (n = 21) or control group (n = 24). The training group completed a periodized running program for 8-weeks (duration: 20-30-minutes per session, intensity: 6-7 Borg Category-Ratio-10 scale rating, frequency: 3 sessions per week). Both groups completed a Cooper 12-minute run test to estimate cardiorespiratory fitness at baseline, mid-study, and post-study. One thousand single nucleotide polymorphisms (SNPs) were assessed via saliva sample collections. Cooper run distance showed a significant improvement (0.23 ± 0.17 km [11.51 ± 9.09%], p < 0.001, ES = 0.48 [95%CI: 0.16-0.32]), following the 8-week program, whilst controls displayed no significant changes (0.03 ± 0.15 km [1.55 ± 6.98%], p = 0.346, ES = 0.08, [95%CI: -0.35-0.95]). A significant portion of the inter-individual variation in Cooper scores could be explained by the number of positive alleles a participant possessed (r = 0.92, R2 = 0.85, p < 0.001). These findings demonstrate the relative influence of key allele variants on an individual's responsiveness to endurance training.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0288996