Search Results - "Chapman, Ross"

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice by Chapman, J. Ross, Taylor, Martin R.G., Boulton, Simon J.

“…DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genetic instability. To preserve genome integrity, organisms have evolved several DSB…”
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H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids by Nakamura, Kyosuke, Saredi, Giulia, Becker, Jordan R., Foster, Benjamin M., Nguyen, Nhuong V., Beyer, Tracey E., Cesa, Laura C., Faull, Peter A., Lukauskas, Saulius, Frimurer, Thomas, Chapman, J. Ross, Bartke, Till, Groth, Anja

“…Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining 1 . HR supresses…”
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REV7 counteracts DNA double-strand break resection and affects PARP inhibition by Xu, Guotai, Chapman, J. Ross, Brandsma, Inger, Yuan, Jingsong, Mistrik, Martin, Bouwman, Peter, Bartkova, Jirina, Gogola, Ewa, Warmerdam, Daniël, Barazas, Marco, Jaspers, Janneke E., Watanabe, Kenji, Pieterse, Mark, Kersbergen, Ariena, Sol, Wendy, Celie, Patrick H. N., Schouten, Philip C., van den Broek, Bram, Salman, Ahmed, Nieuwland, Marja, de Rink, Iris, de Ronde, Jorma, Jalink, Kees, Boulton, Simon J., Chen, Junjie, van Gent, Dik C., Bartek, Jiri, Jonkers, Jos, Borst, Piet, Rottenberg, Sven

“…Loss of REV7 is shown to regulate end resection of double-stranded DNA breaks in BRCA1-deficient cells, leading to PARP inhibitor resistance and restoration of…”
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53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms by Cuella-Martin, Raquel, Oliveira, Catarina, Lockstone, Helen E., Snellenberg, Suzanne, Grolmusova, Natalia, Chapman, J. Ross

“…The tumor suppressor protein 53BP1, a pivotal regulator of DNA double-strand break (DSB) repair, was first identified as a p53-interacting protein over two…”
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53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis by Mirman, Zachary, Sasi, Nanda Kumar, King, Ashleigh, Chapman, J. Ross, de Lange, Titia

“…The efficacy of poly(ADP)-ribose polymerase 1 inhibition (PARPi) in BRCA1-deficient cells depends on 53BP1 and shieldin, which have been proposed to limit…”
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DNA helicases Sgs1 and BLM promote DNA double-strand break resection by Gravel, Serge, Chapman, J Ross, Magill, Christine, Jackson, Stephen P

“…A key cellular response to DNA double-strand breaks (DSBs) is 5'-to-3' DSB resection by nucleases to generate regions of ssDNA that then trigger cell cycle…”
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The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity by Becker, Jordan R., Cuella-Martin, Raquel, Barazas, Marco, Liu, Rui, Oliveira, Catarina, Oliver, Antony W., Bilham, Kirstin, Holt, Abbey B., Blackford, Andrew N., Heierhorst, Jörg, Jonkers, Jos, Rottenberg, Sven, Chapman, J. Ross

“…53BP1 controls a specialized non-homologous end joining (NHEJ) pathway that is essential for adaptive immunity, yet oncogenic in BRCA1 mutant cancers…”
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BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair by Chapman, J Ross, Sossick, Alex J, Boulton, Simon J, Jackson, Stephen P

“…Following irradiation, numerous DNA-damage-responsive proteins rapidly redistribute into microscopically visible subnuclear aggregates, termed…”
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Bayesian geoacoustic inversion of single hydrophone light bulb data using warping dispersion analysis by Bonnel, Julien, Dosso, Stan E, Ross Chapman, N

“…This paper presents geoacoustic inversion of a light bulb implosion recorded during the Shallow Water 2006 experiment. The source is low frequency and…”
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A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis by Altemose, Nicolas, Noor, Nudrat, Bitoun, Emmanuelle, Tumian, Afidalina, Imbeault, Michael, Chapman, J Ross, Aricescu, A Radu, Myers, Simon R

“…PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRDM9-bound loci do not become recombination hotspots. To…”
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Geoacoustic inversion in a dispersive waveguide using warping operators by Bonnel, Julien, Chapman, N. Ross

“…This paper presents a single receiver geoacoustic inversion method adapted for low-frequency impulsive sources. It is applied to light bulb data collected…”
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Low frequency deep ocean ambient noise trend in the Northeast Pacific Ocean by Chapman, N. Ross, Price, Andrea

“…Concern about effects of anthropogenic noise on marine life has stimulated new studies to establish present-day ocean noise levels and compare them to noise…”
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Complex gas hydrate from the Cascadia margin by Lu, Hailong, Seo, Yu-taek, Chapman, N. Ross, Coffin, Richard B, Ripmeester, John A, Moudrakovski, Igor, Pohlman, John, Lee, Jong-won, Gardner, Graeme

“…Natural gas hydrates are a potential source of energy and may play a role in climate change and geological hazards. Most natural gas hydrate appears to be in…”
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Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage by Chapman, J Ross, Jackson, Stephen P

“…Mammalian cells respond to DNA double‐strand breaks (DSBs) by recruiting DNA repair and cell‐cycle checkpoint proteins to such sites. Central to these DNA…”
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Sequential inversion of modal data for sound attenuation in sediment at the New Jersey Shelf by Duan, Rui, Chapman, N Ross, Yang, Kunde, Ma, Yuanliang

“…This paper presents a method for estimating bottom geoacoustic properties especially the sediment attenuation from information contained in normal modes of a…”
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CiiiDER: A tool for predicting and analysing transcription factor binding sites by Gearing, Linden J, Cumming, Helen E, Chapman, Ross, Finkel, Alexander M, Woodhouse, Isaac B, Luu, Kevin, Gould, Jodee A, Forster, Samuel C, Hertzog, Paul J

“…The availability of large amounts of high-throughput genomic, transcriptomic and epigenomic data has provided opportunity to understand regulation of the…”
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Bacterial membrane vesicles transport their DNA cargo into host cells by Bitto, Natalie J., Chapman, Ross, Pidot, Sacha, Costin, Adam, Lo, Camden, Choi, Jasmine, D’Cruze, Tanya, Reynolds, Eric C., Dashper, Stuart G., Turnbull, Lynne, Whitchurch, Cynthia B., Stinear, Timothy P., Stacey, Katryn J., Ferrero, Richard L.

“…Bacterial outer membrane vesicles (OMVs) are extracellular sacs containing biologically active products, such as proteins, cell wall components and toxins…”
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RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection by Chapman, J. Ross, Barral, Patricia, Vannier, Jean-Baptiste, Borel, Valérie, Steger, Martin, Tomas-Loba, Antonia, Sartori, Alessandro A., Adams, Ian R., Batista, Facundo D., Boulton, Simon J.

“…The appropriate execution of DNA double-strand break (DSB) repair is critical for genome stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB…”
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The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4 by Li, Yan, Adamek, Pavel, Zhang, Haijun, Tatsui, Claudio Esteves, Rhines, Laurence D, Mrozkova, Petra, Li, Qin, Kosturakis, Alyssa K, Cassidy, Ryan M, Harrison, Daniel S, Cata, Juan P, Sapire, Kenneth, Zhang, Hongmei, Kennamer-Chapman, Ross M, Jawad, Abdul Basit, Ghetti, Andre, Yan, Jiusheng, Palecek, Jiri, Dougherty, Patrick M

“…Peripheral neuropathy is dose limiting in paclitaxel cancer chemotherapy and can result in both acute pain during treatment and chronic persistent pain in…”
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MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy by Li, Yan, Zhang, Hongmei, Kosturakis, Alyssa K, Cassidy, Ryan M, Zhang, Haijun, Kennamer-Chapman, Ross M, Jawad, Abdul Basit, Colomand, Cecilia M, Harrison, Daniel S, Dougherty, Patrick M

“…Highlights • Paclitaxel increases the expression of ERK1/2, pP38 and NFκB. • Co-application of a TLR4 antagonist blocks paclitaxel-induced MAP kinase…”
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