Search Results - "Chapman, L D"

Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6 by Papaioannou, Virginia E, Chapman, Deborah L

“…Somites, segmented mesodermal units of the vertebrate embryo, are the precursors of adult skeletal muscle, bone and cartilage. During embryogenesis, somite…”
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Three dimensional mapping of strontium in bone by dual energy K-edge subtraction imaging by Cooper, D M L, Chapman, L D, Carter, Y, Wu, Y, Panahifar, A, Britz, H M, Bewer, B, Zhouping, W, Duke, M J M, Doschak, M

“…The bones of many terrestrial vertebrates, including humans, are continually altered through an internal process of turnover known as remodeling. This process…”
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Computed tomography of x-ray index of refraction using the diffraction enhanced imaging method by Dilmanian, F A, Zhong, Z, Ren, B, Wu, X Y, Chapman, L D, Orion, I, Thomlinson, W C

“…Diffraction enhanced imaging (DEI) is a new, synchrotron-based, x-ray radiography method that uses monochromatic, fan-shaped beams, with an analyser crystal…”
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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos by Ludwig, T, Chapman, D L, Papaioannou, V E, Efstratiadis, A

“…Mutations of the human BRCA1 and BRCA2 genes encoding tumor suppressors have been implicated in inherited predisposition to breast and other cancers…”
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Diffraction-enhanced X-ray imaging of articular cartilage by Mollenhauer, J., Aurich, M.E., Zhong, Z., Muehleman, C., Cole, A.A., Hasnah, M., Oltulu, O., Kuettner, K.E., Margulis, A., Chapman, L.D.

“…Objective To introduce a novel X-ray technology, diffraction-enhanced X-ray imaging (DEI), in its early stages of development, for the imaging of articular…”
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Evolution of Mouse T-box Genes by Tandem Duplication and Cluster Dispersion by Agulnik, S. I, Garvey, N, Hancock, S, Ruvinsky, I, Chapman, D. L, Agulnik, I, Bollag, R, Papaioannou, V, Silver, L. M

“…The T-box genes comprise an ancient family of putative transcription factors conserved across species as divergent as Mus musculus and Caenorhabditis elegans…”
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In vivo imaging of rat cortical bone porosity by synchrotron phase contrast micro computed tomography by Pratt, I V, Belev, G, Zhu, N, Chapman, L D, Cooper, D M L

“…Cortical bone is a dynamic tissue which undergoes adaptive and pathological changes throughout life. Direct longitudinal tracking of this remodeling process…”
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Single-and dual-energy CT with monochromatic synchrotron x-rays by Dilmanian, F A, Wu, X Y, Parsons, E C, Ren, B, Kress, J, Button, T M, Chapman, L D, Coderre, J A, Giron, F, Greenberg, D, Krus, D J, Liang, Z, Marcovici, S, Petersen, M J, Roque, C T, Shleifer, M, Slatkin, D N, Thomlinson, W C, Yamamoto, K, Zhong, Z

“…We explored the potential for clinical research of computed tomography (CT) with monochromatic x-rays using the preclinical multiple energy computed tomography…”
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IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium by Firestein, GS, Berger, AE, Tracey, DE, Chosay, JG, Chapman, DL, Paine, MM, Yu, C, Zvaifler, NJ

“…IL-1 can participate in the perpetuation of arthritis through direct stimulation of synoviocytes and augmentation of matrix degradation. Hence, local…”
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Mammographic phantom studies with synchrotron radiation by Johnston, R E, Washburn, D, Pisano, E, Burns, C, Thomlinson, W C, Chapman, L D, Arfelli, F, Gmur, N F, Zhong, Z, Sayers, D

“…To explore the potential improvement in image contrast for breast imaging with use of monoenergetic photons. The x-ray energy available from the National…”
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Eliminating sleep-associated hypoxemia improves growth in infants with bronchopulmonary dysplasia by MOYER-MILEUR, L. J, NIELSON, D. W, PFEFFER, K. D, WITTE, M. K, CHAPMAN, D. L

“…Infants with bronchopulmonary dysplasia (BPD) have been previously reported to have a decrease in growth velocity after stopping supplemental oxygen (SO). SO…”
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Identification of a mouse B-type cyclin which exhibits developmentally regulated expression in the germ line by Chapman, D L, Wolgemuth, D J

“…To begin to examine the function of cyclins in mammalian germ cells, we have screened an adult mouse testis cDNA library for the presence of B-type cyclins. We…”
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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue by Zeitlin, Scott, Efstratiadis, Argiris, Chapman, Deborah L, Papaioannou, Virginia E, Liu, Jeh-Ping

“…The expansion of CAG triplet repeats in the translated region of the human HD gene, encoding a protein (huntingtin) of unknown function, is a dominant mutation…”
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Isolation of the murine cyclin B2 cDNA and characterization of the lineage and temporal specificity of expression of the B1 and B2 cyclins during oogenesis, spermatogenesis and early embryogenesis by CHAPMAN, D. L, WOLGEMUTH, D. J

“…A cDNA encoding the murine cyclin B2 (cycB2) was isolated from an adult mouse testis cDNA library as part of studies designed to identify cyclins involved in…”
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The neural tube patterns vessels developmentally using the VEGF signaling pathway by Hogan, Kelly A, Ambler, Carrie A, Chapman, Deborah L, Bautch, Victoria L

“…Embryonic blood vessels form in a reproducible pattern that interfaces with other embryonic structures and tissues, but the sources and identities of signals…”
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Mammalian Vestigial-like 2, a Cofactor of TEF-1 and MEF2 Transcription Factors That Promotes Skeletal Muscle Differentiation by Maeda, Tomoji, Chapman, Deborah L, Stewart, Alexandre F R

“…Expression of many skeletal muscle-specific genes depends on TEF-1 (transcription enhancer factor-1) and MEF2 transcription factors. In Drosophila , the TEF-1…”
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Disorder and complexity in the atomic structure of the perfect icosahedral alloy of Al-Pd-Mn by de Boissieu M, Stephens, P, Boudard, M, Janot, C, Chapman, DL, Audier, M

“…The atomic structure of the perfect Al)Pd)Mn icosahedral phase has been studied on single grain samples. Using anomalous X-ray diffraction close to the…”
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Regulation of expression of IL-1 receptor antagonist protein in human synovial and dermal fibroblasts by Krzesicki, RF, Hatfield, CA, Bienkowski, MJ, McGuire, JC, Winterrowd, GE, Chapman, DL, Berger, AE, McEwan, RN, Carter, DB, Chosay, JG

“…The IL-1R antagonist protein (IRAP) is a competitive inhibitor of IL-1, which is predominantly synthesized by monocytes. We show that this molecule is also…”
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Defective somite patterning in mouse embryos with reduced levels of Tbx6 by White, Phillip H, Farkas, Deborah R, McFadden, Erin E, Chapman, Deborah L

“…During vertebrate embryogenesis, paraxial mesoderm gives rise to somites, which subsequently develop into the dermis, skeletal muscle, ribs and vertebrae of…”
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A bent Laue–Laue monochromator for a synchrotron-based computed tomography system by Ren, B, Dilmanian, F.A, Chapman, L.D, Ivanov, I, Wu, X.Y, Zhong, Z, Huang, X

“…We designed and tested a two-crystal bent Laue–Laue monochromator for wide, fan-shaped synchrotron X-ray beams for the program multiple energy computed…”
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