Search Results - "Chapman, K. E"

Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour by Harris, A.P, Holmes, M.C, de Kloet, E.R, Chapman, K.E, Seckl, J.R

“…Summary An imbalance between central glucocorticoid (GR) and mineralocorticoid (MR) receptors is proposed to underlie the HPA axis dysregulation that…”
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Decreasing case fatality rate following invasive pneumococcal disease, North East England, 2006-2016 by Houseman, C, Chapman, K E, Manley, P, Gorton, R, Wilson, D, Hughes, G J

“…Declining mortality following invasive pneumococcal disease (IPD) has been observed concurrent with a reduced incidence due to effective pneumococcal conjugate…”
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Serotype dynamics of invasive pneumococcal disease post-PCV7 and pre-PCV13 introduction in North East England by CHAPMAN, K. E., WILSON, D., GORTON, R.

“…The 7-valent pneumococcal conjugate vaccine (PCV7) has been included in the routine childhood immunization programme in the UK since September 2006. A…”
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Decreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice by Qiu, J., Dunbar, D. R., Noble, J., Cairns, C., Carter, R., Kelly, V., Chapman, K. E., Seckl, J. R., Yau, J. L. W.

“…Mice deficient in the glucocorticoid‐regenerating enzyme 11β‐HSD1 resist age‐related spatial memory impairment. To investigate the mechanisms and pathways…”
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Preadipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Keto-Reductase and Contributes to Diet-Induced Visceral Obesity in Vivo by De Sousa Peixoto, R. A, Turban, S, Battle, J. H, Chapman, K. E, Seckl, J. R, Morton, N. M

“…Glucocorticoid excess promotes visceral obesity and cardiovascular disease. Similar features are found in the highly prevalent metabolic syndrome in the…”
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Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet by Michailidou, Z, Carter, R.N, Marshall, E, Sutherland, H.G, Brownstein, D.G, Owen, E, Cockett, K, Kelly, V, Ramage, L, Al-Dujaili, E.A.S, Ross, M, Maraki, I, Newton, K, Holmes, M.C, Seckl, J.R, Morton, N.M, Kenyon, C.J, Chapman, K.E

“…Glucocorticoid hormones are critical to respond and adapt to stress. Genetic variations in the glucocorticoid receptor (GR) gene alter…”
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Cryptic loxP sites in mammalian genomes: genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques by Semprini, S, Troup, T.J, Kotelevtseva, N, King, K, Davis, J.R.E, Mullins, L.J, Chapman, K.E, Dunbar, D.R, Mullins, J.J

“…Cre is widely used for DNA tailoring and, in combination with recombineering techniques, to modify BAC/PAC sequences for generating transgenic animals…”
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Prenatal programming of hepatocyte nuclear factor 4α in the rat : a key mechanism in the 'foetal origins of hyperglycaemia'? by NYIRENDA, M. J, DEAN, S, LYONS, V, CHAPMAN, K. E, SECKL, J. R

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Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture by LAI, M, MCCORMICK, J. A, CHAPMAN, K. E, KELLY, P. A. T, SECKL, J. R, YAU, J. L. W

“…Hyperactivity of the hypothalamic-pituitary-adrenal axis is a characteristic feature of depressive illness. The centrally located corticosteroid receptors, the…”
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5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events by McCormick, J A, Lyons, V, Jacobson, M D, Noble, J, Diorio, J, Nyirenda, M, Weaver, S, Ester, W, Yau, J L, Meaney, M J, Seckl, J R, Chapman, K E

“…Glucocorticoid receptor (GR) gene expression is regulated in a complex tissue-specific manner, notably by early-life environmental events that program tissue…”
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Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α by Rog-Zielinska, E A, Craig, M-A, Manning, J R, Richardson, R V, Gowans, G J, Dunbar, D R, Gharbi, K, Kenyon, C J, Holmes, M C, Hardie, D G, Smith, G L, Chapman, K E

“…Glucocorticoid levels rise dramatically in late gestation to mature foetal organs in readiness for postnatal life. Immature heart function may compromise…”
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Contribution of local regeneration of glucocorticoids to tissue steroid pools by Khan, S, Livingstone, D E W, Zielinska, A, Doig, C L, Cobice, D F, Esteves, C L, Man, J T Y, Homer, N Z M, Seckl, J R, MacKay, C L, Webster, S P, Lavery, G G, Chapman, K E, Walker, B R, Andrew, R

“…11β-Hydroxysteroid dehydrogenase 1 (11βHSD1) is a drug target to attenuate adverse effects of chronic glucocorticoid excess. It catalyses intracellular…”
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Serotype-specific differences in short- and longer-term mortality following invasive pneumococcal disease by HUGHES, G. J., WRIGHT, L. B., CHAPMAN, K. E., WILSON, D., GORTON, R.

“…Invasive pneumococcal disease (IPD), caused by infection with Streptococcus pneumoniae, has a substantial global burden. There are over 90 known serotypes of…”
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Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart by Wilson, K.S., Baily, J., Tucker, C.S., Matrone, G., Vass, S., Moran, C., Chapman, K.E., Mullins, J.J., Kenyon, C., Hadoke, P.W.F., Denvir, M.A.

“…Transient early-life perturbations in glucocorticoids (GC) are linked with cardiovascular disease risk in later life. Here the impact of early life…”
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Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart by Agnew, E J, Garcia-Burgos, A, Richardson, R V, Manos, H, Thomson, A J W, Sooy, K, Just, G, Homer, N Z M, Moran, C M, Brunton, P J, Gray, G A, Chapman, K E

“…Endogenous glucocorticoid action is important in the structural and functional maturation of the fetal heart. In fetal mice, although glucocorticoid…”
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Invasive pneumococcal disease and socioeconomic deprivation: a population study from the North East of England by Chapman, K.E., Wilson, D., Gorton, R.

“…Background Some communicable diseases disproportionately affect poor and vulnerable groups. Invasive pneumococcal disease (IPD) is an important cause of…”
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11β-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner by Vandermosten, L., De Geest, C., Knoops, S., Thijs, G., Chapman, K. E., De Bosscher, K., Opdenakker, G., Van den Steen, P. E.

“…Malaria is a global disease associated with considerable mortality and morbidity. An appropriately balanced immune response is crucial in determining the…”
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11 beta-hydroxysteroid dehydrogenase type 1 is a predominant 11 beta-reductase in the intact perfused rat liver by Jamieson, PM, Walker, BR, Chapman, KE, Andrew, R, Rossiter, S, Seckl

“…11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1), a regulator of intrahepatocellular glucocorticoid activity, is bidirectional in homogenates but…”
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Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses by Chapman, K E, Thomas, A D, Wills, J W, Pfuhler, S, Doak, S H, Jenkins, G J S

“…Recent restrictions on the testing of cosmetic ingredients in animals have resulted in the need to test the genotoxic potential of chemicals exclusively in…”
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Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform by Brown, R W, Chapman, K E, Edwards, C R, Seckl, J R

“…Excess glucocorticoids impair fetal growth and cause teratogenesis. Placental 11 beta-hydroxysteroid dehydrogenase (11 beta HSD) catalyzes the inactivation of…”
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