Search Results - "Chapman, Fiona A"
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The therapeutic potential of apelin in kidney disease
Published in Nature reviews. Nephrology (01-12-2021)“…Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is independently associated with cardiovascular disease. The mainstay of…”
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Cardiovascular and renal effects of apelin in chronic kidney disease: a randomised, double-blind, placebo-controlled, crossover study
Published in Nature communications (14-10-2024)“…Chronic kidney disease (CKD) affects ~10% of the population and cardiovascular disease is its commonest complication. Despite treatment, patient outcomes…”
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Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment
Published in Nature communications (2023)“…In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response,…”
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Hypertension: Current trends and future perspectives
Published in British journal of clinical pharmacology (01-10-2021)“…Hypertension is a significant and increasing global health issue. It is a leading cause of cardiovascular disease and premature death worldwide due to its…”
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Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis
Published in Heart (British Cardiac Society) (01-06-2019)“…Vascular stiffness (VS) and vascular calcification (VC) are surrogate markers of vascular health associated with cardiovascular events. Vitamin K-dependent…”
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Targeting the apelin system for the treatment of cardiovascular diseases
Published in Cardiovascular research (30-12-2023)“…Cardiovascular disease is the leading cause of death worldwide. Its prevalence is rising due to ageing populations and the increasing incidence of diseases…”
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Apelin levels in patients with polyuria-polydipsia syndrome upon copeptin stimulation tests
Published in European journal of endocrinology (29-10-2024)“…Differentiating between arginine vasopressin deficiency (AVP-D) and primary polydipsia (PP) requires a copeptin-stimulation test. We aimed to characterize…”
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Coronary vasospasm in eosinophilic granulomatosis with polyangiitis
Published in Rheumatology (Oxford, England) (01-12-2020)Get full text
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Utility of interval kidney biopsy in ANCA-associated vasculitis
Published in Rheumatology (Oxford, England) (05-05-2022)“…Abstract Objectives ANCA-associated vasculitis (AAV) is a rare autoimmune disorder that commonly involves the kidney. Early identification of kidney…”
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Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function
Published in British journal of clinical pharmacology (01-12-2022)“…Aims Chronic kidney disease (CKD) is common and cardiovascular disease (CVD) is its commonest complication. The apelin system is a potential therapeutic target…”
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Apelin and Copeptin Levels in Patients With Chronic SIAD Treated With Empagliflozin
Published in Journal of the Endocrine Society (23-05-2024)“…Empagliflozin increases sodium levels in patients with a chronic syndrome of inappropriate antidiuresis (SIAD), and dapagliflozin increases apelin levels in…”
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Polygenic risk score as a determinant of risk of non‐melanoma skin cancer in a European‐descent renal transplant cohort
Published in American journal of transplantation (01-03-2019)“…Renal transplant recipients have an increased risk of non‐melanoma skin cancer (NMSC) compared to in the general population. Here, we show polygenic risk…”
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A real-world assessment of mycophenolate mofetil for remission induction in eosinophilic granulomatosis with polyangiitis
Published in Rheumatology international (01-10-2021)“…Eosinophilic granulomatosis with polyangiitis (EGPA) is a form of ANCA-associated vasculitis (AAV). Clinical trials demonstrating the efficacy of mycophenolate…”
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Impact of Increased Duration of Trimethoprim-Sulfamethoxazole Prophylaxis for Pneumocystis Pneumonia After Renal Transplant
Published in Annals of transplantation (06-12-2019)“…BACKGROUND Trimethoprim-sulfamethoxazole (TMP-SMX) is recommended as prophylaxis against Pneumocystis pneumonia (PCP) in renal transplant recipients. The…”
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Apelin Increases Forearm Blood Flow in CKD: SA-PO512
Published in Journal of the American Society of Nephrology (01-11-2023)Get full text
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Apelin Offers Cardiovascular and Renal Benefits in Health and CKD: SA-PO511
Published in Journal of the American Society of Nephrology (01-11-2023)Get full text
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Coronary vasospasm in eosinophilic granulomatosis with polyangiitis
Published in Rheumatology (Oxford, England) (01-12-2020)Get full text
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