Search Results - "Chapman, A.G."

African swine fever virus replication and genomics by Dixon, Linda K., Chapman, David A.G., Netherton, Christopher L., Upton, Chris

“…► African swine fever virus DNA replication and assembly occurs mainly in perinuclear factory areas. ► An early stage of DNA synthesis is detected in the…”
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Genomic analysis of highly virulent Georgia 2007/1 isolate of African swine fever virus by Chapman, David A G, Darby, Alistair C, Da Silva, Melissa, Upton, Chris, Radford, Alan D, Dixon, Linda K

“…African swine fever is widespread in Africa but has occasionally been introduced into other continents. In June 2007, African swine fever was isolated in the…”
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Anti-epileptic activity of group II metabotropic glutamate receptor agonists (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (−)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795) by Moldrich, R.X., Jeffrey, M., Talebi, A., Beart, P.M., Chapman, A.G., Meldrum, B.S.

“…The selective group II metabotropic glutamate receptor (mGlu 2/3) agonists (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and…”
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Domains involved in calcineurin phosphatase inhibition and nuclear localisation in the African swine fever virus A238L protein by Abrams, Charles C, Chapman, Dave A.G, Silk, Rhiannon, Liverani, Elisabetta, Dixon, Linda K

“…Abstract The African swine fever virus A238L protein inhibits calcineurin phosphatase activity and activation of NF-κB and p300 co-activator. An 82 amino acid…”
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Antigen delivery systems for veterinary vaccine development by Brun, Alejandro, Albina, Emmanuel, Barret, Tom, Chapman, David A.G, Czub, Markus, Dixon, Linda K, Keil, Günther M, Klonjkowski, Bernard, Le Potier, Marie-Frédérique, Libeau, Geneviève, Ortego, Javier, Richardson, Jennifer, Takamatsu, Haru-H

“…Abstract The recent advances in molecular genetics, pathogenesis and immunology have provided an optimal framework for developing novel approaches in the…”
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Deletion of the African Swine Fever Virus Gene DP148R Does Not Reduce Virus Replication in Culture but Reduces Virus Virulence in Pigs and Induces High Levels of Protection against Challenge by Reis, Ana L, Goatley, Lynnette C, Jabbar, Tamara, Sanchez-Cordon, Pedro J, Netherton, Christopher L, Chapman, David A G, Dixon, Linda K

“…Many of the approximately 165 proteins encoded by the African swine fever virus (ASFV) genome do not have significant similarity to known proteins and have not…”
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Glutamate receptors and transporters in genetic and acquired models of epilepsy by Meldrum, B.S, Akbar, M.T, Chapman, A.G

“…Glutamate, the principal excitatory neurotransmitter in the brain, acts on three families of ionotropic receptor—AMPA…”
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Identification of a Functional Small Noncoding RNA of African Swine Fever Virus by Dunn, Laura E M, Ivens, Alasdair, Netherton, Christopher L, Chapman, David A G, Beard, Philippa M

“…(ASFV) causes a lethal hemorrhagic disease of domestic pigs, against which no vaccine is available. ASFV has a large, double-stranded DNA genome that encodes…”
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Comparison of the genome sequences of non-pathogenic and pathogenic African swine fever virus isolates by Chapman, D.A.G, Tcherepanov, V, Upton, C, Dixon, L.K

“…The genomic coding sequences, apart from the inverted terminal repeats and cross-links, have been determined for two African swine fever virus (ASFV) isolates…”
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Antigen delivery systems for veterinary vaccine development Viral-vector based delivery systems by BRUN, Alejandro, ALBINA, Emmanuel, ORTEGO, Javier, RICHARDSON, Jennifer, TAKAMATSU, Haru-H, BARRET, Tom, CHAPMAN, David A. G, CZUB, Markus, DIXON, Linda K, KEIL, Günther M, KLONJKOWSKI, Bernard, LE POTIER, Marie-Frederique, LIBEAU, Geneviève

“…The recent advances in molecular genetics, pathogenesis and immunology have provided an optimal framework for developing novel approaches in the rational…”
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Anticonvulsant effects of 7‐nitroindazole in rodents with reflex epilepsy may result from L‐arginine accumulation or a reduction in nitric oxide or L‐citrulline formation by Smith, S.E., Man, C.M., Yip, P.K., Tang, E., Chapman, A.G., Meldrum, B.S.

“…1 To investigate the role of nitric oxide in epilepsy we have studied the effects of agents which affect nitric oxide synthesis in sound‐induced seizures in…”
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Improving baculovirus recombination by Zhao, Yuguang, Chapman, David A. G., Jones, Ian M.

“…Recombinant baculoviruses have established themselves as a favoured technology for the high‐level expression of recombinant proteins. The construction of…”
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Anticonvulsant effect of reduced NMDA receptor expression in audiogenic DBA/2 mice by Chapman, A.G., Woodburn, V.L., Woodruff, G.N., Meldrum, B.S.

“…Pretreatment of DBA/2 mice ( n = 14–15 per group) with an 18-mer antisense probe to the NMDA-receptor subunit NR1 (2 × 1 μg, or 2 × 83 pmol, NR1 antisense…”
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Plasma amino acids in childhood epileptic encephalopathies by Ferrie, C.D., Bird, S., Tilling, K., Maisey, M.N., Chapman, A.G., Robinson, R.O.

“…Abnormalities in plasma amino acid levels have been noted in patients with various epilepsies, and sometimes also in their first degree relatives. We sought to…”
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Excitotoxicity of NMDA and kainic acid is modulated by nigrostriatal dopaminergic fibres by Chapman, A G, Dürmuller, N, Lees, G J, Meldrum, B S

“…The excitotoxic action of N-methyl-D-aspartate (NMDA) and of kinase (KA) has been assessed by measuring glutamic acid decarboxylase (GAD) and choline…”
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CGS 19755 is a potent and competitive antagonist at NMDA-type receptors by Lehmann, J, Chapman, A G, Meldrum, B S, Hutchison, A, Tsai, C, Wood, P L

“…The N-Methyl-D-aspartate (NMDA)-type receptor blocking properties of CGS 19755, a novel, rigid analog of 2-amino-5-phosphonopentanoate, were demonstrated in…”
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Electrolytic lesions of the locus coeruleus or 6-hydroxydopamine lesions of the medial forebrain bundle protect against excitotoxic damage in rat hippocampus by Arvin, B, Le Peillet, E, Dürmüller, N, Chapman, A G, Meldrum, B S

“…Unilateral lesioning of the rat locus coeruleus by an electric current (0.3 mA/10 s) reduces the ipsilateral hippocampal tissue content of dopamine (DA) and…”
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An extended hydrophobic interactive surface of Yersinia pestis Caf1M chaperone is essential for subunit binding and F1 capsule assembly by MacIntyre, Sheila, Zyrianova, Irina M., Chernovskaya, Tatiana V., Leonard, Mary, Rudenko, Elena G., Zav'yalov, Vladimir P., Chapman, David A. G.

“…A single polypeptide subunit, Caf1, polymerizes to form a dense, poorly defined structure (F1 capsule) on the surface of Yersinia pestis. The caf‐encoded…”
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Benzodiazepine receptors and their relationship to the treatment of epilepsy by Meldrum, B S, Chapman, A G

“…Benzodiazepines (BDZ) interact with components of neuronal membranes to modify excitability in three different ways. Action at a high affinity central receptor…”
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Bidirectional effects of beta-carbolines in reflex epilepsy by Chapman, A G, De Sarro, G B, Premachandra, M, Meldrum, B S

“…Derivatives of ethyl-beta-carboline-3-carboxylate, ZK 91296, ZK 93423 and ZK 95962 have potent anticonvulsant activity against sound-induced seizures in…”
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