Search Results - "Chaplin, Melanie J."

Phenotype shift from atypical scrapie to CH1641 following experimental transmission in sheep by Simmons, Marion M, Moore, S Jo, Lockey, Richard, Chaplin, Melanie J, Konold, Timm, Vickery, Christopher, Spiropoulos, John

“…The interactions of host and infecting strain in ovine transmissible spongiform encephalopathies are known to be complex, and have a profound effect on the…”
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Experimental oral transmission of atypical scrapie to sheep by Simmons, Marion M, Moore, S Jo, Konold, Timm, Thurston, Lisa, Terry, Linda A, Thorne, Leigh, Lockey, Richard, Vickery, Chris, Hawkins, Stephen A C, Chaplin, Melanie J, Spiropoulos, John

“…To investigate the possibility of oral transmission of atypical scrapie in sheep and determine the distribution of infectivity in the animals' peripheral…”
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Experimental H-type and L-type bovine spongiform encephalopathy in cattle: observation of two clinical syndromes and diagnostic challenges by Konold, Timm, Bone, Gemma E, Clifford, Derek, Chaplin, Melanie J, Cawthraw, Saira, Stack, Michael J, Simmons, Marion M

“…The majority of atypical bovine spongiform encephalopathy (BSE) cases so far identified worldwide have been detected by active surveillance. Consequently the…”
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Codon 141 polymorphisms of the ovine prion protein gene affect the phenotype of classical scrapie transmitted from goats to sheep by Konold, Timm, Phelan, Laura J, Donnachie, Ben R, Chaplin, Melanie J, Cawthraw, Saira, González, Lorenzo

“…A study to investigate transmission of classical scrapie via goat milk was carried out in sheep: firstly, lambs were challenged orally with goat scrapie brain…”
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Atypical scrapie/Nor98 in a sheep from New Zealand by Kittelberger, Reinhold, Chaplin, Melanie J, Simmons, Marion M, Ramirez-Villaescusa, Ana, McIntyre, Lachlan, MacDiarmid, Stuart C, Hannah, Michaela J, Jenner, Judy, Bueno, Rudolfo, Bayliss, Daniele, Black, Hugh, Pigott, Clive J, O'Keefe, Joseph S

“…In a consignment of sheep brains from New Zealand, to be used in Europe as negative control material in scrapie rapid screening test evaluations, brain samples…”
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Detection and localisation of PrP(Sc) in the liver of sheep infected with scrapie and bovine spongiform encephalopathy by Everest, Sally J, Ramsay, Andrew M, Chaplin, Melanie J, Everitt, Sharon, Stack, Michael J, Neale, Michael H, Jeffrey, Martin, Moore, S Jo, Bellworthy, Susan J, Terry, Linda A

“…Prions are largely contained within the nervous and lymphoid tissue of transmissible spongiform encephalopathy (TSE) infected animals. However, following…”
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The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep by Simmons, Marion M, Konold, Timm, Thurston, Lisa, Bellworthy, Susan J, Chaplin, Melanie J, Moore, S Jo

“…Atypical scrapie was first identified in Norwegian sheep in 1998 and has subsequently been identified in many countries. Retrospective studies have identified…”
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Immunohistochemical and biochemical characteristics of BSE and CWD in experimentally infected European red deer (Cervus elaphus elaphus) by Martin, Stuart, Jeffrey, Martin, González, Lorenzo, Sisó, Sílvia, Reid, Hugh W, Steele, Philip, Dagleish, Mark P, Stack, Michael J, Chaplin, Melanie J, Balachandran, Aru

“…The cause of the bovine spongiform encephalopathy (BSE) epidemic in the United Kingdom (UK) was the inclusion of contaminated meat and bone meal in the protein…”
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Abnormalities in Brainstem Auditory Evoked Potentials in Sheep with Transmissible Spongiform Encephalopathies and Lack of a Clear Pathological Relationship by Konold, Timm, Phelan, Laura J, Cawthraw, Saira, Simmons, Marion M, Chaplin, Melanie J, González, Lorenzo

“…Scrapie is transmissible spongiform encephalopathy (TSE), which causes neurological signs in sheep, but confirmatory diagnosis is usually made postmortem on…”
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Atypical scrapie in sheep from a UK research flock which is free from classical scrapie by Simmons, Hugh A, Simmons, Marion M, Spencer, Yvonne I, Chaplin, Melanie J, Povey, Gill, Davis, Andrew, Ortiz-Pelaez, Angel, Hunter, Nora, Matthews, Danny, Wrathall, Anthony E

“…In the wake of the epidemic of bovine spongiform encephalopathy the British government established a flock of sheep from which scrapie-free animals are…”
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Studies of the transmissibility of the agent of bovine spongiform encephalopathy to the domestic chicken by Moore, Jo, Hawkins, Stephen Ac, Austin, Anthony R, Konold, Timm, Green, Robert B, Blamire, Ian W, Dexter, Ian, Stack, Michael J, Chaplin, Melanie J, Langeveld, Jan Pm, Simmons, Marion M, Spencer, Yvonne I, Webb, Paul R, Dawson, Michael, Wells, Gerald Ah

“…Transmission of the prion disease bovine spongiform encephalopathy (BSE) occurred accidentally to cattle and several other mammalian species via feed…”
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Pruritus is a common feature in sheep infected with the BSE agent by Konold, Timm, Bone, Gemma, Vidal-Diez, Alberto, Tortosa, Raul, Davis, Andrew, Dexter, Glenda, Hill, Peter, Jeffrey, Martin, Simmons, Marion M, Chaplin, Melanie J, Bellworthy, Susan J, Berthelin-Baker, Christine

“…The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine…”
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Transmissibility studies of vacuolar changes in the rostral colliculus of pigs by Konold, Timm, Spiropoulos, John, Chaplin, Melanie J, Thorne, Leigh, Spencer, Yvonne I, Wells, Gerald A H, Hawkins, Steve A C

“…Histopathological examinations of brains from healthy pigs have revealed localised vacuolar changes, predominantly in the rostral colliculus, that are similar…”
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L-BSE experimentally transmitted to sheep presents as a unique disease phenotype by Simmons, Marion M, Chaplin, Melanie J, Konold, Timm, Casalone, Cristina, Beck, Katy E, Thorne, Leigh, Everitt, Sharon, Floyd, Tobias, Clifford, Derek, Spiropoulos, John

“…Apart from prion protein genotype, the factors determining the host range and susceptiblity for specific transmissible spongiform encephalopathy agents remain…”
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pathological and molecular but not clinical phenotypes are maintained after second passage of experimental atypical bovine spongiform encephalopathy in cattle by Konold, Timm, Phelan, Laura J, Clifford, Derek, Chaplin, Melanie J, Cawthraw, Saira, Stack, Michael J, Simmons, Marion M

“…BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs), classified as H-type and L-type BSE based on the Western immunoblot profiles, are naturally…”
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Detection and Localisation of PrPSc in the Liver of Sheep Infected with Scrapie and Bovine Spongiform Encephalopathy by Everest, Sally J., Ramsay, Andrew M., Chaplin, Melanie J., Everitt, Sharon, Stack, Michael J., Neale, Michael H., Jeffrey, Martin, Moore, S. Jo, Bellworthy, Susan J., Terry, Linda A.

“…Prions are largely contained within the nervous and lymphoid tissue of transmissible spongiform encephalopathy (TSE) infected animals. However, following…”
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Experimental transmission of chronic wasting disease agent from mule deer to cattle by the intracerebral route by Hamir, A.N, Kunkle, R.A, Cutlip, R.C, Miller, J.M, O'Rourke, K.I, Williams, E.S, Miller, M.W, Stack, M.J, Chaplin, M.J, Richt, J.A

“…This communication reports final observations on experimental transmission of chronic wasting disease (CWD) from mule deer to cattle by the intracerebral…”
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Diagnosis of preclinical scrapie in samples of rectal mucosa by González, Lorenzo, Jeffrey, Martin, SisÓ, Sílvia, Martin, Stuart, Bellworthy, Sue J., Stack, Mick J., Chaplin, Melanie J., Davis, Linda, Dagleish, Mark P., Reid, Hugh W.

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Transmission of sheep scrapie to elk (Cervus elaphus nelsoni) by intracerebral inoculation: final outcome of the experiment by Hamir, Amir N, Miller, Janice M, Cutlip, Randall C, Kunkle, Robert A, Jenny, Allen L, Stack, Mick J, Chaplin, Melanie J, Richt, Juergen A

“…This is a final report of an experimental transmission of sheep scrapie agent by intracerebral inoculation to Rocky Mountain elk (Cervus elaphus nelsoni). It…”
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Preliminary findings on the experimental transmission of chronic wasting disease agent of mule deer to cattle by Hamir, AN, Cutlip, RC, Miller, JM, Williams, ES, Stack, MJ, Miller, MW, O'Rourke, KI, Chaplin, MJ

“…National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA. To determine the transmissibility of chronic wasting disease (CWD) to cattle and to provide…”
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