Search Results - "Chaplin, Jenny"

An Enzyme Library Approach to Biocatalysis:  Development of Nitrilases for Enantioselective Production of Carboxylic Acid Derivatives by DeSantis, Grace, Zhu, Zuolin, Greenberg, William A, Wong, Kelvin, Chaplin, Jenny, Hanson, Sarah R, Farwell, Bob, Nicholson, Lawrence W, Rand, Cynthia L, Weiner, David P, Robertson, Dan E, Burk, Mark J

“…The discovery, from Nature, of a large and diverse set of nitrilases is reported. The utility of this nitrilase library for identifying enzymes that catalyze…”
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Abstract 4863: PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors by Tumang, Joseph, Gomes, Bruno, Wythes, Martin, Crosignani, Stefano, Bingham, Patrick, Bottemanne, Pauline, Cannelle, Hélène, Cauwenberghs, Sandra, Chaplin, Jenny, Dalvie, Deepak, Denies, Sofie, De Maeseneire, Coraline, Folger, Peter, Frederix, Kim, Guo, Jie, Hardwick, James, Hook, Ken, Jessen, Katti, Kindt, Erick, Letellier, Marie-Claire, Liao, Kai-Hsin, Li, Wenlin, Maegley, Karen, Marillier, Reece, Miller, Nichol, Murray, Brion, Pirson, Romain, Preillon, Julie, Rabolli, Virginie, Ray, Chad, Scales, Stephanie, Srirangam, Jay, Solowiej, Jim, Streiner, Nicole, Torti, Vince, Tsaparikos, Konstantinos, Vicini, Paolo, Driessens, Gregory, Kraus, Manfred

“…Abstract Tumors use tryptophan-catabolizing enzymes such as Indoleamine 2,3-dioxygenase-1 (IDO-1) to induce an immunosuppressive microenvironment. IDO-1…”
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An Enzyme Library Approach to Biocatalysis:  Development of Nitrilases for Enantioselective Production of Carboxylic Acid Derivatives [J. Am. Chem. Soc. 2002, 124 (31), 9024−9025] by DeSantis, Grace, Zhu, Zuolin, Greenberg, William A, Wong, Kelvin, Chaplin, Jenny, Hanson, Sarah R, Farwell, Bob, Nicholson, Lawrence W, Rand, Cynthia L, Weiner, David P, Robertson, Dan, Burk, Mark J

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