Search Results - "Chapleo, Christopher B"

Indoline analogs of idazoxan: potent .alpha.2-antagonists and .alpha.1-agonists by Fagan, Gay P, Chapleo, Christopher B, Lane, Anthony C, Myers, Malcolm, Roach, Alan G, Smith, Colin F. C, Stillings, Michael R, Welbourn, Anthony P

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Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 4. Amidines by Chapleo, Christopher B, Myers, Peter L, Smith, Alan C. B, Stillings, Michael R, Tulloch, Ian F, Walter, Donald S

“…Two different structural types of 2-aryl-1,3,4-thiadiazole amidines were synthesized and evaluated for anticonvulsant activity. Enhancement of the inherent…”
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Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 1. Hydrazines by Chapleo, Christopher B, Myers, Malcolm, Myers, Peter L, Saville, John F, Smith, Alan C. B, Stillings, Michael R, Tulloch, Ian F, Walter, Donald S, Welbourn, Anthony P

“…The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described. The combination of preferred aromatic…”
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Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 3. Guanidines by Chapleo, Christopher B, Myers, Peter L, Smith, Alan C. B, Tulloch, Ian F, Walter, Donald S

“…The synthesis and anticonvulsant activity of a number of 2-aryl-5-guanidino-1,3,4 thiadiazoles are described. The unsubstituted guanidine 2a was found to…”
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Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 3. Guanidines [Erratum to document cited in CA106(19):156365r] by Chapleo, Christopher B, Myers, Peter L, Smith, Alan C. B, Tulloch, Ian F, Turner, Stephen, Walter, Donald S

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Heteroaromatic analogs of the .alpha.2-adrenoreceptor partial agonist clonidine by Chapleo, Christopher B, Butler, Richard C. M, England, David C, Myers, Peter L, Roach, Alan G, Smith, Colin F. C, Stillings, Michael R, Tulloch, Ian F

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Synthesis of some potential antihypertensive phthalazinylguanidines and quinoxalinylguanidines by Chapleo, Christopher B, Doxey, John C, Myers, Peter L

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alpha.-Adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional .alpha.2-adrenoreceptor antagonists by Welbourn, Anthony P, Chapleo, Christopher B, Lane, Anthony C, Myers, Peter L, Roach, Alan G, Smith, Colin F. C, Stillings, Michael R, Tulloch, Ian F

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alpha.-Adrenoreceptor reagents. 3. Synthesis of some 2-substituted 1,4-benzodioxans as selective presynaptic .alpha.2-adrenoreceptor antagonists by Stillings, Michael R, Chapleo, Christopher B, Butler, Richard C. M, Davis, J. Alfred, England, C. David, Myers, Malcolm, Myers, Peter L, Tweddle, Neil, Welbourn, Anthony P

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alpha.-Adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic .alpha.2-adrenoreceptor antagonists and potential antidepressants by Chapleo, Christopher B, Myers, Peter L, Butler, Richard C. M, Doxey, John C, Roach, Alan G, Smith, Colin F. C

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alpha.-Adrenoceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on .alpha.-adrenoreceptor activity by Chapleo, Christopher B, Myers, Peter L, Butler, Richard C. M, Davis, John A, Doxey, John C, Higgins, Stanley D, Myers, Malcolm, Roach, Alan G, Smith, Colin F. C

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Calciferol and its relatives. Part 19. Synthetic applications of cyclic orthoesters: Stereospecific synthesis of a bicyclic alcohol related to the vitamins D2 by Chapleo, C B, Hallett, P, Lythgoe, B, Waterhouse, I, Wright, P W

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Indoline analogues of idazoxan: potent α2-antagonists and α1-agonists by FAGAN, G. P, CHAPLEO, C. B, LANE, A. C, MYERS, M, ROACH, A. G, SMITH, C. F. C, STILLINGS, M. R, WELBOURN, A. P

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Heteroaromatic analogues of the α2-adrenoreceptor partial agonist clonidine by CHAPLEO, C. B, BUTLER, R. C. M, ENGLAND, D. C, MYERS, P. L, ROACH, A. G, SMITH, C. F. C, STILLINGS, M. R, TULLOCH, I. F

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Synthesis of α- and β-(hypoxanthin-9-yl and adenin-9-yl) carboxylates by Birkett, Paul R., Chapleo, Christopher B., Mackenzie, Grahame

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Alpha-adrenoreceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on alpha-adrenoreceptor activity by Chapleo, C B, Myers, P L, Butler, R C, Davis, J A, Doxey, J C, Higgins, S D, Myers, M, Roach, A G, Smith, C F, Stillings, M R

“…Modification of the 1,4-benzodioxan ring present in RX 781094 has not previously been considered. This paper describes a number of analogues of this ring…”
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Synthesis of 2‐(2‐imidazolinyl) substituted 2,3‐dihydro‐4 H ‐1,4‐benzothiazine and 3,4‐dihydro‐2 H ‐1,4‐benzoxazines by Butler, Richard C. M., Chapleo, Christopher B., Myers, Peter L., Welbourn, Anthony P.

“…An investigation into the synthesis of benzoxazine, benzoxathiane and benzothiazine derivatives of 2‐(2‐imidazolinyl)‐1,4‐benzodioxane has been carried out…”
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Synthesis of some potential antihypertensive phthalazinyl- and quinoxalinylguanidines by Chapleo, C B, Doxey, J C, Myers, P L

“…A series of phthalazinyl- and quinoxalinylguanidines has been synthesized and evaluated for potential antihypertensive activity. Unsubstituted guanidines were…”
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Synthesis of 2-(2-imidazolinyl) substituted 2,3-dihydro-4H-1,4-benzothiazine and 3,4-dihydro-2H-1,4-benzoxazines by Butler, Richard C. M., Chapleo, Christopher B., Myers, Peter L., Welbourn, Anthony P.

“…An investigation into the synthesis of benzoxazine, benzoxathiane and benzothiazine derivatives of 2‐(2‐imidazolinyl)‐1,4‐benzodioxane has been carried out…”
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Comparison of the alpha-adrenoceptor profiles of clonidine and two oxygenated arylamino imidazolines by Chapleo, C B, Doxey, J C, Frank, L W, Myers, P L, Roach, A G, Smith, C F, Virdee, N K

“…The profiles of 2-(3,4-dimethoxyphenylamino)-imidazoline HCl (RX 77171) and 2-[6-(1,4-benzodioxanylamino)]imidazoline maleate (RX 801074) were compared with…”
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