Search Results - "Chapkin, RS"

Obesity promotes colonic stem cell expansion during cancer initiation by DeClercq, V, McMurray, D.N, Chapkin, R.S

“…Highlights • Colonic stem cell number is significantly higher in obese AOM-injected mice. • Apoptotic response to AOM injection is reduced in high fat fed…”
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Abstract P1-10-09: EPHA2-targeting enhances eicosapentaenoic acid cytotoxicity against triple-negative inflammatory breast cancer via ABCA1 inhibition–mediated membrane rigidity by Torres-Adorno, AM, Vitrac, H, Qi, Y, Tan, L, Levental, KR, Fan, Y-Y, Yang, P, Chapkin, RS, Eckhardt, BL, Ueno, NT

“…Abstract Background: Effective treatment options for triple-negative inflammatory breast cancer (TN-IBC), the most aggressive form of breast cancer, are…”
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Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production by Fan, Yang-Yi, Ly, Lan H, Barhoumi, Rola, McMurray, David N, Chapkin, Robert S

“…To date, the proximal molecular targets through which dietary n-3 polyunsaturated fatty acids (PUFA) suppress the inflammatory process have not been…”
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Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts by Fan, Yang-Yi, McMurray, David N, Ly, Lan H, Chapkin, Robert S

“…In vitro evidence indicates that (n-3) polyunsaturated fatty acids (PUFA) suppress T-cell activation in part by displacing proteins from lipid rafts,…”
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n‐3 PUFA Alter caveolae lipid composition and resident protein localization in mouse colon by Ma, David W.L., Seo, Jeongmin, Davidson, Laurie A., Callaway, Evelyn S., Fan, Yang-Yi, Lupton, Joanne R., Chapkin, Robert S.

“…ABSTRACT Caveolae, by virtue of their unique lipid environment, serve as signaling platforms that regulate cellular events. Perturbations in caveolae lipid…”
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Dietary (n-3) polyunsaturated fatty acids modulate murine Th1/Th2 balance toward the Th2 pole by suppression of Th1 development by Zhang, Ping, Smith, Roger, Chapkin, Robert S, McMurray, David N

“…We showed that dietary long-chain (n-3) PUFAs present in fish oil (FO) affect CD4(+) T cell proliferation and cytokine production in C57BL/6 mice. To test the…”
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n−3 PUFA and membrane microdomains: a new frontier in bioactive lipid research by Ma, David W.L., Seo, Jeongmin, Switzer, Kirsten C., Fan, Yang-Yi, McMurray, David N., Lupton, Joanne R., Chapkin, Robert S.

“…In recent years, our understanding of the plasma membrane has changed considerably as our knowledge of lipid microdomains has expanded. Lipid microdomains…”
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Importance of dietary gamma-linolenic acid in human health and nutrition by Fan, Y Y, Chapkin, R S

“…Considerable debate remains regarding the distinct biological activities of individual polyunsaturated fatty acids (PUFA). One of the most interesting yet…”
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Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat by DAVIDSON, Laurie A, NGUYEN, Danh V, CHAPKIN, Robert S, HOKANSON, Regina M, CALLAWAY, Evelyn S, ISETT, Robert B, TURNER, Nancy D, DOUGHERTY, Edward R, NAISYIN WANG, LUPTON, Joanne R, CARROLL, Raymond J

“…The mechanisms by which n-3 polyunsaturated fatty acids (PUFAs) decrease colon tumor formation have not been fully elucidated. Examination of genes up- or…”
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The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes by Ng, Yeevoon, Barhoumi, Rola, Tjalkens, Ronald B., Fan, Yang-Yi, Kolar, Satya, Wang, Naisyin, Lupton, Joanne R., Chapkin, Robert S.

“…Docosahexaenoic acid (DHA, 22:6 n-3) from fish oil, and butyrate, a fiber fermentation product, work coordinately to protect against colon tumorigenesis in…”
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Chemopreventive n-3 fatty acids activate RXRα in colonocytes by Fan, Yang-Yi, Spencer, Thomas E., Wang, Naisyin, Moyer, Mary P., Chapkin, Robert S.

“…The underlying mechanisms by which n-3 polyunsaturated fatty acids (PUFA) exert a chemopreventive effect in the colon have not been elucidated. Retinoid X…”
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An increase in reactive oxygen species by dietary fish oil coupled with the attenuation of antioxidant defenses by dietary pectin enhances rat colonocyte apoptosis by Sanders, Lisa M, Henderson, Cara E, Hong, Mee Young, Barhoumi, Rola, Burghardt, Robert C, Wang, Naisyin, Spinka, Christine M, Carroll, Raymond J, Turner, Nancy D, Chapkin, Robert S, Lupton, Joanne R

“…We showed previously that the dietary combination of fish oil, rich in (n-3) fatty acids, and the fermentable fiber pectin enhances colonocyte apoptosis in a…”
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Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes by Hong, Mee Young, Chapkin, Robert S., Barhoumi, Rola, Burghardt, Robert C., Turner, Nancy D., Henderson, Cara E., Sanders, Lisa M., Fan, Yang-Yi, Davidson, Laurie A., Murphy, Mary E., Spinka, Christine M., Carroll, Raymond J., Lupton, Joanne R.

“…We have shown that a combination of fish oil (high in n-3 fatty acids) with the butyrate-producing fiber pectin, upregulates apoptosis in colon cells exposed…”
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n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes by Collett, E D, Davidson, L A, Fan, Y Y, Lupton, J R, Chapkin, R S

“…Ras proteins are critical regulators of cell function, including growth, differentiation, and apoptosis, with membrane localization of the protein being a…”
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Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis by CHANG, W.-C. L, CHAPKIN, R. S, LUPTON, J. R

“…In order to determine the prognostic significance of proliferation, differentiation, and apoptosis as intermediate markers for colon tumor development, these…”
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Dietary n-3 polyunsaturated fatty acids promote activation-induced cell death in Th1-polarized murine CD4+ T-cells by Switzer, Kirsten C., Fan, Yang-Yi, Wang, Naisyin, McMurray, David N., Chapkin, Robert S.

“…Dietary n-3 PUFAs have been shown to attenuate T-cell-mediated inflammation. To investigate whether dietary n-3 PUFAs promote activation-induced cell death…”
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(n-3) Polyunsaturated fatty acids promote activation-induced cell death in murine T lymphocytes by Switzer, Kirsten C, McMurray, David N, Morris, Jeffrey S, Chapkin, Robert S

“…Previous studies showing dietary (n-3) polyunsaturated fatty acids (PUFA) attenuate T cell immune-mediated inflammatory diseases led us to hypothesize that…”
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Influence of dietary n-3 fatty acids on macrophage glycerophospholipid molecular species and peptidoleukotriene synthesis by Chapkin, RS, Akoh, CC, Miller, CC

“…The study examined the ability of dietary n-3 fatty acids to modify mouse peritoneal macrophage glycerophospholipid molecular species and peptidoleukotriene…”
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Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis by MA, David W. L, FINNELL, Richard H, BOZINOV, Daniel, LUPTON, Joanne R, CHAPKIN, Robert S, DAVIDSON, Laurie A, CALLAWAY, Evelyn S, SPIEGELSTEIN, Ofer, PIEDRAHITA, Jorge A, SALBAUM, J. Michael, KAPPEN, Claudia, WEEKS, Brad R, JAMES, Jill

“…Low dietary folate intake is associated with an increased risk for colon cancer; however, relevant genetic animal models are lacking. We therefore investigated…”
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Dietary (n-3) polyunsaturated fatty acids suppress murine lymphoproliferation, interleukin-2 secretion, and the formation of diacylglycerol and ceramide by Jolly, C A, Jiang, Y H, Chapkin, R S, McMurray, D N

“…Elucidation of the mechanism(s) by which dietary fish oil, enriched in eicosapentaenoic acid (EPA, 20:5(n-3)] and docosahexaenoic acid [DHA, 22:6(n-3)],…”
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