Search Results - "Chapin, Douglas"

Reduction of brain kynurenic acid improves cognitive function by Kozak, Rouba, Campbell, Brian M, Strick, Christine A, Horner, Weldon, Hoffmann, William E, Kiss, Tamas, Chapin, Douglas S, McGinnis, Dina, Abbott, Amanda L, Roberts, Brooke M, Fonseca, Kari, Guanowsky, Victor, Young, Damon A, Seymour, Patricia A, Dounay, Amy, Hajos, Mihaly, Williams, Graham V, Castner, Stacy A

“…The elevation of kynurenic acid (KYNA) observed in schizophrenic patients may contribute to core symptoms arising from glutamate hypofunction, including…”
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Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia by VERHOEST, Patrick R, CHAPIN, Douglas S, PANDIT, Jayvardhan, PROULX-LAFRANCE, Caroline, SCHMIDT, Anne W, SCHMIDT, Christopher J, SUICIAK, Judith A, LIRAS, Spiros, CORMAN, Michael, FONSECA, Kari, HARMS, John F, XINJUN HOU, MARR, Eric S, MENNITI, Frank S, NELSON, Frederick, O'CONNOR, Rebecca

“…By utilizing structure-based drug design (SBDD) knowledge, a novel class of phosphodiesterase (PDE) 10A inhibitors was identified. The structure-based drug…”
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Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis by Siuciak, Judith A., Chapin, Douglas S., Harms, John F., Lebel, Lorraine A., McCarthy, Sheryl A., Chambers, Leslie, Shrikhande, Alka, Wong, Stephen, Menniti, Frank S., Schmidt, Christopher J.

“…Phosphodiesterase 10A (PDE10A) is a recently identified cyclic nucleotide phosphodiesterase expressed primarily in dopaminoreceptive medium spiny neurons of…”
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Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function by Siuciak, Judith A., McCarthy, Sheryl A., Chapin, Douglas S., Fujiwara, Remie A., James, Larry C., Williams, Robert D., Stock, Jeffrey L., McNeish, John D., Strick, Christine A., Menniti, Frank S., Schmidt, Christopher J.

“…PDE10A is a newly identified phosphodiesterase that is highly expressed by the medium spiny projection neurons of the striatum. In order to investigate the…”
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Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo by Kleiman, Robin J, Chapin, Douglas S, Christoffersen, Curt, Freeman, Jody, Fonseca, Kari R, Geoghegan, Kieran F, Grimwood, Sarah, Guanowsky, Victor, Hajós, Mihály, Harms, John F, Helal, Christopher J, Hoffmann, William E, Kocan, Geralyn P, Majchrzak, Mark J, McGinnis, Dina, McLean, Stafford, Menniti, Frank S, Nelson, Fredrick, Roof, Robin, Schmidt, Anne W, Seymour, Patricia A, Stephenson, Diane T, Tingley, Francis David, Vanase-Frawley, Michelle, Verhoest, Patrick R, Schmidt, Christopher J

“…Cyclic nucleotides are critical regulators of synaptic plasticity and participate in requisite signaling cascades implicated across multiple neurotransmitter…”
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Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme by Siuciak, Judith A., McCarthy, Sheryl A., Chapin, Douglas S., Martin, Ashley N.

“…Rationale Phosphodiesterases (PDEs) belonging to the PDE4 family control intracellular concentrations of cyclic adenosine monophosphate (cAMP) by catalyzing…”
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CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity by Siuciak, Judith A, Chapin, Douglas S, McCarthy, Sheryl A, Guanowsky, Victor, Brown, Janice, Chiang, Phoebe, Marala, Ravi, Patterson, Terrell, Seymour, Patricia A, Swick, Andrew, Iredale, Philip A

“…CP-809,101 is a potent, functionally selective 5-HT(2C) agonist that displays approximately 100% efficacy in vitro. The aim of the present studies was to…”
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Antipsychotic profile of rolipram : efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4b (PDE4B) enzyme by SIUCIAK, Judith A, CHAPIN, Douglas S, MCCARTHY, Sheryl A, MARTIN, Ashley N

“…Recent studies provide evidence for reduced phosphodiesterase-4B (PDE4B) as a genetic susceptibility factor as well as suggesting an association of several…”
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Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia by Helal, Christopher J, Kang, Zhijun, Hou, Xinjun, Pandit, Jayvardhan, Chappie, Thomas A, Humphrey, John M, Marr, Eric S, Fennell, Kimberly F, Chenard, Lois K, Fox, Carol, Schmidt, Christopher J, Williams, Robert D, Chapin, Douglas S, Siuciak, Judith, Lebel, Lorraine, Menniti, Frank, Cianfrogna, Julia, Fonseca, Kari R, Nelson, Frederick R, O’Connor, Rebecca, MacDougall, Mary, McDowell, Laura, Liras, Spiros

“…Utilizing structure-based virtual library design and scoring, a novel chimeric series of phosphodiesterase 10A (PDE10A) inhibitors was discovered by…”
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Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease by Liston, Dane R., Nielsen, Jann A., Villalobos, Anabella, Chapin, Douglas, Jones, Shawn B., Hubbard, Sean T., Shalaby, Ismail A., Ramirez, Andres, Nason, Deane, White, W.Frost

“…Cholinesterase inhibitors vary in their selectivity for acetylcholinesterase versus butyrylcholinesterase. We examined several cholinesterase inhibitors and…”
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Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/Bl6N congenic background by Siuciak, Judith A., McCarthy, Sheryl A., Chapin, Douglas S., Martin, Ashley N., Harms, John F., Schmidt, Christopher J.

“…The phenotype of genetically modified animals is strongly influenced by both the genetic background of the animal as well as environmental factors. We have…”
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Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia † Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1) by Verhoest, Patrick R, Chapin, Douglas S, Corman, Michael, Fonseca, Kari, Harms, John F, Hou, Xinjun, Marr, Eric S, Menniti, Frank S, Nelson, Frederick, O’Connor, Rebecca, Pandit, Jayvardhan, Proulx-LaFrance, Caroline, Schmidt, Anne W, Schmidt, Christopher J, Suiciak, Judith A, Liras, Spiros

“…By utilizing structure-based drug design (SBDD) knowledge, a novel class of phosphodiesterase (PDE) 10A inhibitors was identified. The structure-based drug…”
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Nuclear safety. Nuclear power plants and their fuel as terrorist targets by Chapin, Douglas M, Cohen, Karl P, Davis, W Kenneth, Kintner, Edwin E, Koch, Leonard J, Landis, John W, Levenson, Milton, Mandil, I Harry, Pate, Zack T, Rockwell, Theodore, Schriesheim, Alan, Simpson, John W, Squire, Alexander, Starr, Chauncey, Stone, Henry E, Taylor, John J, Todreas, Neil E, Wolfe, Bertram, Zebroski, Edwin L

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The U.S. Election Assistance Commission: What Role in the Administration of Elections? by Montjoy, Robert S., Chapin, Douglas M.

“…What role in the administration of elections will the new U.S. Election Assistance Commission (EAC) play, and how does that role differ from past federal…”
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Novel Benzisoxazole Derivatives as Potent and Selective Inhibitors of Acetylcholinesterase by Villalobos, Anabella, Blake, James F, Biggers, C. Kelly, Butler, Todd W, Chapin, Douglas S, Chen, Yuhpyng L, Ives, Jeffrey L, Jones, Shawn B, Liston, Dane R

“…A series of N-benzylpiperidine benzisoxazoles has been developed as potent and selective inhibitors of the enzyme acetylcholinesterase (AChE). The…”
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Cross-site strain comparison of pharmacological deficits in the touchscreen visual discrimination test by Mohler, Eric G., Ding, Zhiyong, Rueter, Lynne E., Chapin, Douglas, Young, Damon, Kozak, Rouba

“…The low rate of success for identifying effective treatments for cognitive dysfunction has prompted recent efforts to improve pharmaceutical discovery and…”
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Non-Precinct Place Voting and Election Administration by Chapin, Douglas

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Nuclear Power Plants and Their Fuel as Terrorist Targets by Chapin, Douglas M., Cohen, Karl P., Davis, W. Kenneth, Kintner, Edwin E., Koch, Leonard J., Landis, John W., Levenson, Milton, Mandil, I. Harry, Pate, Zack T., Rockwell, Theodore, Schriesheim, Alan, Simpson, John W., Squire, Alexander, Starr, Chauncey, Stone, Henry E., Taylor, John J., Todreas, Neil E., Wolfe, Bertram, Zebroski, Edwin L.

“…In the wake of the 11 September attack on the World Trade Center, a large number of outrageous public statements appeared, claiming that any attack on a…”
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Design and Synthesis of 1-Heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one Derivatives as Potent, Selective Acetylcholinesterase Inhibitors by Nagel, Arthur A, Liston, Dane R, Jung, Stanley, Mahar, Melissa, Vincent, Lawrence A, Chapin, Douglas, Chen, Yuhpyng L, Hubbard, Sean, Ives, Jeffrey L

“…Herein is described the synthesis and structure--activity relationship of a novel series of aromatic and heteroaromatic 3-(1-benzyl-4-piperidinyl)propan-1-one…”
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Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase by Lowe, John A, Archer, Robert L, Chapin, Douglas S, Cheng, John B, Helweg, David, Johnson, Jonathan L, Koe, B. Kenneth, Lebel, Lorraine A, Moore, Peter F

“…A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase…”
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