Search Results - "Chaparala, Anusha"
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Molecules from American Ginseng Suppress Colitis through Nuclear Factor Erythroid-2-Related Factor 2
Published in Nutrients (21-06-2020)“…Ulcerative colitis (UC) is a chronic inflammatory bowel disease that affects millions of people worldwide and increases the risk of colorectal cancer (CRC)…”
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Journal Article -
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Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds
Published in Oncotarget (03-01-2017)“…Ulcerative colitis (UC) is a chronic lifelong inflammatory disorder of the colon, which, while untreated, has a relapsing and remitting course with increasing…”
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Journal Article -
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FTO-Dependent N 6 -Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…-Methyladenosine (m A) is the most abundant modification of mammalian mRNAs. RNA methylation fine tunes RNA stability and translation, altering cell fate. The…”
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Journal Article -
4
Abstract A36: Developing a novel treatment for advanced ovarian cancer by targeting the c-Met pathway
Published in Clinical cancer research (01-07-2020)“…Abstract Approximately one-third of epithelial ovarian tumors exhibit higher levels of c-Met, a receptor tyrosine kinase, activated by Hepatocyte Growth Factor…”
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Journal Article -
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FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling
Published in Cancer research (Chicago, Ill.) (30-06-2020)“…N 6 -Methyladenosine (m 6 A) is the most abundant modification of mammalian messenger RNAs (mRNA). RNA methylation fine tunes RNA stability and translation,…”
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Journal Article -
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Abstract 5503: Panaxynol, a potential treatment for colitis, selectively targets pro-inflammatory macrophages for DNA damage and apoptosis
Published in Cancer research (Chicago, Ill.) (01-08-2015)“…Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that has been associated with a high risk for colorectal cancer. Since available…”
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Journal Article -
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Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice
Published in Oncotarget (02-06-2020)“…Ulcerative colitis has a significant impact on the quality of life for the patients, and can substantially increase the risk of colon cancer in patients…”
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Journal Article -
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Mechanism of Action of American Ginseng and its Components in the Treatment of Ulcerative Colitis
Published 01-01-2017“…Inflammatory bowel diseases (IBD), mainly ulcerative colitis (UC), Crohn’s disease (CD), are chronic, idiopathic, inflammatory diseases of the gastrointestinal…”
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Dissertation -
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Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties
Published in Oncotarget (16-08-2016)“…Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is associated with an increased risk of colorectal cancer in 8-10 years after disease…”
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Journal Article -
10
Characterization, Molecular Docking, and In Vitro Dissolution Studies of Solid Dispersions of 20(S)-Protopanaxadiol
Published in Molecules (Basel, Switzerland) (11-02-2017)“…In this study, we prepared solid dispersions (SDs) of 20( )-protopanaxadiol (PPD) using a melting-solvent method with different polymers, in order to improve…”
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Journal Article -
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Abstract 5104: Identification of cancer-specific COPI inhibitors and their associated apoptotic cell death pathways
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Abstract The COPI complex is a heptameric complex involved in multiple aspects of intravesicular transport. Recently, Shtutman et al. identified the ζ1 subunit…”
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Journal Article -
12
Role of micro RNA 148/152 family in cancer progression
Published 01-01-2014“…Micro RNA are small single stranded RNA that regulate the expression of various genes. MiRNA guide the mRNA disintegrating RISC complex to the complimentary…”
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Dissertation