Search Results - "Chao, Tony"
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Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans
Published in Cell metabolism (14-06-2016)“…Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of…”
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Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans
Published in Diabetes (New York, N.Y.) (01-12-2014)“…Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic tissue owing to its ability to dissipate energy as heat. Despite a plethora of…”
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3
Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress
Published in Cell metabolism (04-08-2015)“…Since the presence of brown adipose tissue (BAT) was confirmed in adult humans, BAT has become a therapeutic target for obesity and insulin resistance. We…”
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Human and Mouse Brown Adipose Tissue Mitochondria Have Comparable UCP1 Function
Published in Cell metabolism (09-08-2016)“…Brown adipose tissue (BAT) plays an important role in mammalian thermoregulation. The component of BAT mitochondria that permits this function is the inner…”
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Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma
Published in American journal of physiology: endocrinology and metabolism (01-08-2016)“…Burn trauma results in prolonged hypermetabolism and skeletal muscle wasting. How hypermetabolism contributes to muscle wasting in burn patients remains…”
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Increased oxidative phosphorylation in lymphocytes does not atone for decreased cell numbers after burn injury
Published in Innate immunity (London, England) (01-07-2020)“…The acute systemic inflammatory response syndrome (SIRS) and multiorgan dysfunction (MOD) that occur in large burn injuries may be attributed, in part, to…”
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ASCs derived from burn patients are more prone to increased oxidative metabolism and reactive oxygen species upon passaging
Published in Stem cell research & therapy (06-05-2021)“…Patients with severe burn injury (over 20% of the total body surface area) experience profound hypermetabolism which significantly prolongs wound healing…”
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Brown Adipose Tissue Is Linked to a Distinct Thermoregulatory Response to Mild Cold in People
Published in Frontiers in physiology (19-04-2016)“…Brown adipose tissue (BAT) plays an important role in thermoregulation in rodents. Its role in temperature homeostasis in people is less studied. To this end,…”
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A Prospective Observational Study Comparing Clinical Sepsis Criteria to Protein Biomarkers Reveals a Role for Vascular Dysfunction in Burn Sepsis
Published in Critical care explorations (01-01-2022)“…To compare the diagnostic value of clinical sepsis criteria to novel protein biomarkers in the burn patient. Prospective observational study. American Burn…”
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Open Versus Thoracoscopic Repair of Congenital Diaphragmatic Hernia: A 19-Year Review in a Tertiary Referral Centre in Hong Kong
Published in Journal of pediatric surgery (01-04-2024)“…Congenital diaphragmatic hernia (CDH) is a developmental defect that causes herniation of abdominal organs into the thoracic cavity with significant morbidity…”
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Oxidative pathophysiology following volumetric muscle loss injury in a porcine model
Published in Journal of applied physiology (1985) (01-06-2019)“…Volumetric muscle loss (VML) occurs after severe orthopedic trauma and results in loss of muscle fibers and function that can leave patients permanently…”
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832: ENTERAL RESUSCITATION OF MODERATE BURNS SHOWS SIMILAR EFFICACY TO IV RESUSCITATION IN A SWINE MODEL
Published in Critical care medicine (01-01-2018)Get full text
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Diagnostic value of mitochondrial DNA and peripheral blood mononuclear cell respirometry for burn-related sepsis
Published in Shock (Augusta, Ga.) (03-11-2022)Get full text
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DIAGNOSTIC VALUE OF MITOCHONDRIAL DNA AND PERIPHERAL BLOOD MONONUCLEAR CELL RESPIROMETRY FOR BURN-RELATED SEPSIS
Published in Shock (Augusta, Ga.) (01-02-2023)“…Background: Sepsis is the leading cause of mortality among burn patients that survive acute resuscitation. Clinical criteria have poor diagnostic value for…”
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Intravenous Fluids Used for Resuscitation Alters the Adrenal Response to Traumatic Burn injury Depending on the Volume Given
Published in The FASEB journal (01-04-2018)“…Severe thermal injury induces hypermetabolic stress which initiates a disruption in the hypothalamic‐pituitary‐adrenal (HPA) axis. While glucocorticoids…”
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The Effects of Fluid Resuscitation on Renal and Cardiac Mitochondrial Function in a Severely Burned Swine Model
Published in The FASEB journal (01-04-2018)“…Severe burn injury covering over 30% of the total body surface area (TBSA) results in a systemic inflammatory response which can lead to multi organ…”
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Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children
Published in Medicine and science in sports and exercise (01-03-2018)“…Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved muscle mass and…”
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Characterization of Mitochondrial Bioenergetics of Adipose‐Derived Stem Cells from Burned and Non‐burned Patients
Published in The FASEB journal (01-04-2019)“…Prolonged hypermetabolism is a hallmark of severe burn injury (over 20% of the total body surface area) that produces cachexia and hinders the wound healing…”
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9 The Potential for Mitochondrial Respiration and Circulating mtDNA Levels for Early Diagnosis of Sepsis in Burn Patients
Published in Journal of burn care & research (03-03-2020)“…Abstract Introduction Sepsis is a common consequence of burns associated with greater morbidity. While early treatment of sepsis in burn patients improves…”
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Skeletal Muscle Protein Breakdown Remains Elevated in Pediatric Burn Survivors up to One-Year Post-Injury
Published in Shock (Augusta, Ga.) (01-11-2015)“…ABSTRACTAcute alterations in skeletal muscle protein metabolism are a well-established event associated with the stress response to burns. Nevertheless, the…”
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