Search Results - "Chao, Michael J"

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia by Tcw, Julia, Qian, Lu, Pipalia, Nina H, Chao, Michael J, Liang, Shuang A, Shi, Yang, Jain, Bharat R, Bertelsen, Sarah E, Kapoor, Manav, Marcora, Edoardo, Sikora, Elizabeth, Andrews, Elizabeth J, Martini, Alessandra C, Karch, Celeste M, Head, Elizabeth, Holtzman, David M, Zhang, Bin, Wang, Minghui, Maxfield, Frederick R, Poon, Wayne W, Goate, Alison M

“…The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's disease (AD), on human brain cellular function remains unclear…”
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Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB11501 is regulated by vitamin D by Ramagopalan, Sreeram V, Maugeri, Narelle J, Handunnetthi, Lahiru, Lincoln, Matthew R, Orton, Sarah-Michelle, Dyment, David A, Deluca, Gabriele C, Herrera, Blanca M, Chao, Michael J, Sadovnick, A Dessa, Ebers, George C, Knight, Julian C

“…Multiple sclerosis (MS) is a complex trait in which allelic variation in the MHC class II region exerts the single strongest effect on genetic risk…”
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A modifier of Huntington's disease onset at the MLH1 locus by Lee, Jong-Min, Chao, Michael J, Harold, Denise, Abu Elneel, Kawther, Gillis, Tammy, Holmans, Peter, Jones, Lesley, Orth, Michael, Myers, Richard H, Kwak, Seung, Wheeler, Vanessa C, MacDonald, Marcy E, Gusella, James F

“…Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by an expanded CAG repeat in HTT. Many clinical characteristics of HD such…”
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Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases by Kapoor, Manav, Chao, Michael J., Johnson, Emma C., Novikova, Gloriia, Lai, Dongbing, Meyers, Jacquelyn L., Schulman, Jessica, Nurnberger, John I., Porjesz, Bernice, Liu, Yunlong, Foroud, Tatiana, Edenberg, Howard J., Marcora, Edoardo, Agrawal, Arpana, Goate, Alison

“…Identification of causal variants and genes underlying genome-wide association study (GWAS) loci is essential to understand the biology of alcohol use disorder…”
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Population-specific genetic modification of Huntington's disease in Venezuela by Chao, Michael J, Kim, Kyung-Hee, Shin, Jun Wan, Lucente, Diane, Wheeler, Vanessa C, Li, Hong, Roach, Jared C, Hood, Leroy, Wexler, Nancy S, Jardim, Laura B, Holmans, Peter, Jones, Lesley, Orth, Michael, Kwak, Seung, MacDonald, Marcy E, Gusella, James F, Lee, Jong-Min

“…Modifiers of Mendelian disorders can provide insights into disease mechanisms and guide therapeutic strategies. A recent genome-wide association (GWA) study…”
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Genetic Modification of Huntington Disease Acts Early in the Prediagnosis Phase by Long, Jeffrey D., Lee, Jong-Min, Aylward, Elizabeth H., Gillis, Tammy, Mysore, Jayalakshmi Srinidhi, Abu Elneel, Kawther, Chao, Michael J., Paulsen, Jane S., MacDonald, Marcy E., Gusella, James F.

“…Age at onset of Huntington disease, an inherited neurodegenerative disorder, is influenced by the size of the disease-causing CAG trinucleotide repeat…”
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Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility by Lincoln, Matthew R, Ramagopalan, Sreeram V, Chao, Michael J, Herrera, Blanca M, DeLuca, Gabriele C, Orton, Sarah-Michelle, Dyment, David A, Sadovnick, A. Dessa, Ebers, George C

“…Multiple sclerosis (MS), a common central nervous system inflammatory disease, has a major heritable component. Susceptibility is associated with the MHC class…”
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Sequence-Level Analysis of the Major European Huntington Disease Haplotype by Lee, Jong-Min, Kim, Kyung-Hee, Shin, Aram, Chao, Michael J., Abu Elneel, Kawther, Gillis, Tammy, Mysore, Jayalakshmi Srinidhi, Kaye, Julia A., Zahed, Hengameh, Kratter, Ian H., Daub, Aaron C., Finkbeiner, Steven, Li, Hong, Roach, Jared C., Goodman, Nathan, Hood, Leroy, Myers, Richard H., MacDonald, Marcy E., Gusella, James F.

“…Huntington disease (HD) reflects the dominant consequences of a CAG-repeat expansion in HTT. Analysis of common SNP-based haplotypes has revealed that most…”
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The inheritance of resistance alleles in multiple sclerosis by Ramagopalan, Sreeram V, Morris, Andrew P, Dyment, David A, Herrera, Blanca M, DeLuca, Gabriele C, Lincoln, Matthew R, Orton, Sarah M, Chao, Michael J, Sadovnick, A Dessa, Ebers, George C

“…Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk…”
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HLA class I alleles tag HLA-DRB11501 haplotypes for differential risk in multiple sclerosis susceptibility by Chao, Michael J, Barnardo, Martin C.N.M, Lincoln, Matthew R, Ramagopalan, Sreeram V, Herrera, Blanca M, Dyment, David A, Montpetit, Alexandre, Sadovnick, A. Dessa, Knight, Julian C, Ebers, George C

“…The major locus for multiple sclerosis (MS) susceptibility is located within the class II region of the Major Histocompatibility Complex (MHC). HLA-DRB1…”
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Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9 by Shin, Jun Wan, Kim, Kyung-Hee, Chao, Michael J, Atwal, Ranjit S, Gillis, Tammy, MacDonald, Marcy E, Gusella, James F, Lee, Jong-Min

“…A comprehensive genetics-based precision medicine strategy to selectively and permanently inactivate only mutant, not normal allele, could benefit many…”
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Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease by Lee, Jong-Min, Wheeler, Vanessa C., Chao, Michael J., Vonsattel, Jean Paul G., Pinto, Ricardo Mouro, Lucente, Diane, Abu-Elneel, Kawther, Ramos, Eliana Marisa, Mysore, Jayalakshmi Srinidhi, Gillis, Tammy, MacDonald, Marcy E., Gusella, James F., Harold, Denise, Stone, Timothy C., Escott-Price, Valentina, Han, Jun, Vedernikov, Alexey, Holmans, Peter, Jones, Lesley, Kwak, Seung, Mahmoudi, Mithra, Orth, Michael, Landwehrmeyer, G. Bernhard, Paulsen, Jane S., Dorsey, E. Ray, Shoulson, Ira, Myers, Richard H.

“…As a Mendelian neurodegenerative disorder, the genetic risk of Huntington’s disease (HD) is conferred entirely by an HTT CAG repeat expansion whose length is…”
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Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects by Kim, Kyung-Hee, Hong, Eun Pyo, Shin, Jun Wan, Chao, Michael J., Loupe, Jacob, Gillis, Tammy, Mysore, Jayalakshmi S., Holmans, Peter, Jones, Lesley, Orth, Michael, Monckton, Darren G., Long, Jeffrey D., Kwak, Seung, Lee, Ramee, Gusella, James F., MacDonald, Marcy E., Lee, Jong-Min

“…A recent genome-wide association study of Huntington disease (HD) implicated genes involved in DNA maintenance processes as modifiers of onset, including…”
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Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset by McAllister, Branduff, Donaldson, Jasmine, Binda, Caroline S., Powell, Sophie, Chughtai, Uroosa, Edwards, Gareth, Stone, Joseph, Lobanov, Sergey, Elliston, Linda, Schuhmacher, Laura-Nadine, Rees, Elliott, Menzies, Georgina, Ciosi, Marc, Maxwell, Alastair, Chao, Michael J., Hong, Eun Pyo, Lucente, Diane, Wheeler, Vanessa, Lee, Jong-Min, MacDonald, Marcy E., Long, Jeffrey D., Aylward, Elizabeth H., Landwehrmeyer, G. Bernhard, Rosser, Anne E., Paulsen, Jane S., Williams, Nigel M., Gusella, James F., Monckton, Darren G., Allen, Nicholas D., Holmans, Peter, Jones, Lesley, Massey, Thomas H.

“…The age at onset of motor symptoms in Huntington’s disease (HD) is driven by HTT CAG repeat length but modified by other genes. In this study, we used exome…”
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Sex differences in the genetic predictors of Alzheimer's pathology by Dumitrescu, Logan, Barnes, Lisa L, Thambisetty, Madhav, Beecham, Gary, Kunkle, Brian, Bush, William S, Gifford, Katherine A, Chibnik, Lori B, Mukherjee, Shubhabrata, De Jager, Philip L, Kukull, Walter, Crane, Paul K, Resnick, Susan M, Keene, C Dirk, Montine, Thomas J, Schellenberg, Gerard D, Deming, Yuetiva, Chao, Michael J, Huentelman, Matt, Martin, Eden R, Hamilton-Nelson, Kara, Shaw, Leslie M, Trojanowski, John Q, Peskind, Elaine R, Cruchaga, Carlos, Pericak-Vance, Margaret A, Goate, Alison M, Cox, Nancy J, Haines, Jonathan L, Zetterberg, Henrik, Blennow, Kaj, Larson, Eric B, Johnson, Sterling C, Albert, Marilyn, Bennett, David A, Schneider, Julie A, Jefferson, Angela L, Hohman, Timothy J

“…Autopsy measures of Alzheimer's disease neuropathology have been leveraged as endophenotypes in previous genome-wide association studies (GWAS). However,…”
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Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington’s Disease by Ellis, Natalie, Tee, Amelia, McAllister, Branduff, Massey, Thomas, McLauchlan, Duncan, Stone, Timothy, Correia, Kevin, Loupe, Jacob, Kim, Kyung-Hee, Barker, Douglas, Hong, Eun Pyo, Chao, Michael J., Long, Jeffrey D., Lucente, Diane, Vonsattel, Jean Paul G., Pinto, Ricardo Mouro, Elneel, Kawther Abu, Ramos, Eliana Marisa, Mysore, Jayalakshmi Srinidhi, Gillis, Tammy, Wheeler, Vanessa C., Medway, Christopher, Hall, Lynsey, Kwak, Seung, Sampaio, Cristina, Ciosi, Marc, Maxwell, Alastair, Chatzi, Afroditi, Monckton, Darren G., Orth, Michael, Landwehrmeyer, G. Bernhard, Paulsen, Jane S., Shoulson, Ira, Myers, Richard H., van Duijn, Erik, Rickards, Hugh, MacDonald, Marcy E., Lee, Jong-min, Gusella, James F., Jones, Lesley, Holmans, Peter

“…Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene. It is diagnosed following a standardized…”
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Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis by Orton, Sarah-Michelle, Morris, Andrew P, Herrera, Blanca M, Ramagopalan, Sreeram V, Lincoln, Matthew R, Chao, Michael J, Vieth, Reinhold, Sadovnick, A. Dessa, Ebers, George C

“…BACKGROUND: Multiple sclerosis (MS) risk is determined by both genes and environment. One of the most striking features of MS is its geographic distribution,…”
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Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples by Johnson, Emma C, Sanchez-Roige, Sandra, Acion, Laura, Adams, Mark J, Bucholz, Kathleen K, Chan, Grace, Chao, Michael J, Chorlian, David B, Dick, Danielle M, Edenberg, Howard J, Foroud, Tatiana, Hayward, Caroline, Heron, Jon, Hesselbrock, Victor, Hickman, Matthew, Kendler, Kenneth S, Kinreich, Sivan, Kramer, John, Kuo, Sally I-Chun, Kuperman, Samuel, Lai, Dongbing, McIntosh, Andrew M, Meyers, Jacquelyn L, Plawecki, Martin H, Porjesz, Bernice, Porteous, David, Schuckit, Marc A, Su, Jinni, Zang, Yong, Palmer, Abraham A, Agrawal, Arpana, Clarke, Toni-Kim, Edwards, Alexis C

“…Studies suggest that alcohol consumption and alcohol use disorders have distinct genetic backgrounds. We examined whether polygenic risk scores (PRS) for…”
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Haplotype-based stratification of Huntington's disease by Chao, Michael J, Gillis, Tammy, Atwal, Ranjit S, Mysore, Jayalakshmi Srinidhi, Arjomand, Jamshid, Harold, Denise, Holmans, Peter, Jones, Lesley, Orth, Michael, Myers, Richard H, Kwak, Seung, Wheeler, Vanessa C, MacDonald, Marcy E, Gusella, James F, Lee, Jong-Min

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by expansion of a CAG trinucleotide repeat in HTT, resulting in an extended…”
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Methylation of class II transactivator gene promoter IV is not associated with susceptibility to multiple sclerosis by Ramagopalan, Sreeram V, Dyment, David A, Morrison, Katie M, Herrera, Blanca M, Deluca, Gabriele C, Lincoln, Matthew R, Orton, Sarah M, Handunnetthi, Lahiru, Chao, Michael J, Sadovnick, A Dessa, Ebers, George C

“…Multiple sclerosis (MS) is a complex trait in which alleles at or near the class II loci HLA-DRB1 and HLA-DQB1 contribute significantly to genetic risk. The…”
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